2021
JAZF1 heterozygous knockout mice show altered adipose development and metabolism
Jeong J, Jang S, Park S, Kwon W, Kim S, Jang S, Ko J, Park S, Lim S, Yoon D, Yi J, Lee S, Kim M, Choi S, Ryoo Z. JAZF1 heterozygous knockout mice show altered adipose development and metabolism. Cell & Bioscience 2021, 11: 161. PMID: 34407873, PMCID: PMC8375039, DOI: 10.1186/s13578-021-00625-1.Peer-Reviewed Original ResearchHigh-fat dietAdipocyte differentiationNormal dietMetabolic disordersType 2 diabetes mellitusAdipose developmentImpaired adipocyte differentiationImpaired glucose homeostasisBody fat massAdipose tissue massHeterozygous knockout miceRegulation of PPARγKnockout mice showDiabetes mellitusControl miceFat massMouse embryonic fibroblastsGlucose homeostasisKnockout miceConclusionOur findingsTissue massAdipose tissueMice showJAZF1 expressionVivo model
2018
Placental growth factor (PlGF) is linked to inflammation and metabolic disorders in mice with diet-induced obesity
Kang M, Jeong J, Lee J, Park S, Sung Y, Choi M, Kwon W, Jang S, Choi K, Choo Y, Yoon D, Kim M, Ryoo Z. Placental growth factor (PlGF) is linked to inflammation and metabolic disorders in mice with diet-induced obesity. Endocrine Journal 2018, 65: ej17-0363. PMID: 29434073, DOI: 10.1507/endocrj.ej17-0363.Peer-Reviewed Original ResearchConceptsHigh-fat dietDiet-induced obesityCD3/CD28 stimulationEpididymal white adipose tissueObesity-induced inflammationPlacental growth factorVascular endothelial growth factorT cellsMetabolic disordersTg miceT cell differentiationAdipose tissueHFD miceGrowth factorCD28 stimulationInflammatory T cell differentiationPro-inflammatory cytokines IL-6Mice fed high-fat dietType 17 helper T cellsFed high-fat dietWT-HFD miceSystemic metabolic disordersIsolated T lymphocytesHelper T cellsCytokines IL-6
2016
Serum amyloid A1 levels and amyloid deposition following a high-fat diet challenge in transgenic mice overexpressing hepatic serum amyloid A1
Jang W, Jeong J, Kim S, Kang M, Sung Y, Choi M, Park S, Kim M, Kim S, Ryoo Z. Serum amyloid A1 levels and amyloid deposition following a high-fat diet challenge in transgenic mice overexpressing hepatic serum amyloid A1. Applied Physiology Nutrition And Metabolism 2016, 41: 640-648. PMID: 27218680, DOI: 10.1139/apnm-2015-0369.Peer-Reviewed Original ResearchConceptsHigh-fat dietSAA1 levelsAmyloid depositionTg miceMetabolic disturbancesTransgenic miceHepatic serum amyloid A1Elevated levelsImpaired glucose toleranceLow-grade inflammationLocal cytokine expressionChronic inflammatory conditionsHigh-fat diet challengeSerum amyloid A1Acute phase response proteinsMajor precursor proteinCrohn's diseaseGlucose toleranceCytokine expressionInflammatory conditionsMetabolic parametersSerum amyloidMetabolic disordersAmyloid depositsDiet challenge