Toll-like receptor 4 plays a role in macrophage phagocytosis during peritoneal sepsis
Anand RJ, Kohler JW, Cavallo JA, Li J, Dubowski T, Hackam DJ. Toll-like receptor 4 plays a role in macrophage phagocytosis during peritoneal sepsis. Journal Of Pediatric Surgery 2007, 42: 927-933. PMID: 17560196, DOI: 10.1016/j.jpedsurg.2007.01.023.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBacterial TranslocationCell LineDisease Models, AnimalEnterocolitis, NecrotizingEscherichia coliEscherichia coli InfectionsImmunity, InnateLipopolysaccharidesMacrophages, PeritonealMaleMiceMice, Inbred C3HMice, KnockoutPeritoneal CavityPeritonitisPhagocytosisPhagosomesSepsisToll-Like Receptor 4ConceptsToll-like receptor 4TLR4 WT micePeritoneal sepsisBacterial clearancePeritoneal cavityReceptor 4Functional Toll-like receptor 4Rate of phagocytosisMacrophage phagocytosisMutant Toll-like receptor 4Impaired bacterial clearanceTLR4 mutant miceSeptic courseIntraperitoneal injectionTLR4 mutantTherapeutic targetSepsis