A Critical Role for TLR4 in the Pathogenesis of Necrotizing Enterocolitis by Modulating Intestinal Injury and Repair
Leaphart CL, Cavallo J, Gribar SC, Cetin S, Li J, Branca MF, Dubowski TD, Sodhi CP, Hackam DJ. A Critical Role for TLR4 in the Pathogenesis of Necrotizing Enterocolitis by Modulating Intestinal Injury and Repair. The Journal Of Immunology 2007, 179: 4808-4820. PMID: 17878380, DOI: 10.4049/jimmunol.179.7.4808.Peer-Reviewed Original ResearchConceptsDevelopment of NECNEC developmentTLR4 activationEnterocyte apoptosisEnterocyte migrationTLR4-mutant C3H/HeJ miceC3H/HeOuJ miceC3H/HeJ miceTranslocation of LPSExpression of TLR4Cause of deathMurine intestinal epitheliumFocal adhesion kinaseNEC severityCritical roleIntestinal injuryMucosal injuryPreterm infantsNecrotizing enterocolitisEnterocyte injuryInflamed intestineIntestinal healingGastrointestinal diseasesHeJ miceIntestinal repairToll-like receptor 4 plays a role in macrophage phagocytosis during peritoneal sepsis
Anand RJ, Kohler JW, Cavallo JA, Li J, Dubowski T, Hackam DJ. Toll-like receptor 4 plays a role in macrophage phagocytosis during peritoneal sepsis. Journal Of Pediatric Surgery 2007, 42: 927-933. PMID: 17560196, DOI: 10.1016/j.jpedsurg.2007.01.023.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBacterial TranslocationCell LineDisease Models, AnimalEnterocolitis, NecrotizingEscherichia coliEscherichia coli InfectionsImmunity, InnateLipopolysaccharidesMacrophages, PeritonealMaleMiceMice, Inbred C3HMice, KnockoutPeritoneal CavityPeritonitisPhagocytosisPhagosomesSepsisToll-Like Receptor 4ConceptsToll-like receptor 4TLR4 WT micePeritoneal sepsisBacterial clearancePeritoneal cavityReceptor 4Functional Toll-like receptor 4Rate of phagocytosisMacrophage phagocytosisMutant Toll-like receptor 4Impaired bacterial clearanceTLR4 mutant miceSeptic courseIntraperitoneal injectionTLR4 mutantTherapeutic targetSepsis