The Impact of Chemotherapy and Radiation Therapy on the Remodeling of Acellular Dermal Matrices in Staged, Prosthetic Breast Reconstruction
Myckatyn TM, Cavallo JA, Sharma K, Gangopadhyay N, Dudas JR, Roma AA, Baalman S, Tenenbaum MM, Matthews BD, Deeken CR. The Impact of Chemotherapy and Radiation Therapy on the Remodeling of Acellular Dermal Matrices in Staged, Prosthetic Breast Reconstruction. Plastic & Reconstructive Surgery 2015, 135: 43e-57e. PMID: 25539350, PMCID: PMC4515029, DOI: 10.1097/prs.0000000000000807.Peer-Reviewed Original ResearchConceptsExtracellular matrix depositionAcellular dermal matrixNeoadjuvant chemotherapyBiopsy specimensCellular infiltrationDermal matrixCLINICAL QUESTION/LEVELType IMatrix depositionDermal matrix remodelingImpact of chemotherapyProsthetic breast reconstructionMultiple biopsy specimensMastectomy skin flapsAdjuvant therapyBreast reconstructionFibrous encapsulationRadiation therapySkin flapsChemotherapyTreatment groupsTissue expanderBreast implantsBiopsy locationAcellular dermis