The tumor-derived cytokine Chi3l1 induces neutrophil extracellular traps that promote T cell exclusion in triple-negative breast cancer
Taifour T, Attalla S, Zuo D, Gu Y, Sanguin-Gendreau V, Proud H, Solymoss E, Bui T, Kuasne H, Papavasiliou V, Lee C, Kamle S, Siegel P, Elias J, Park M, Muller W. The tumor-derived cytokine Chi3l1 induces neutrophil extracellular traps that promote T cell exclusion in triple-negative breast cancer. Immunity 2023, 56: 2755-2772.e8. PMID: 38039967, DOI: 10.1016/j.immuni.2023.11.002.Peer-Reviewed Original ResearchTriple-negative breast cancerImmune checkpoint blockadeBreast cancerAnti-tumor immune responseHuman triple-negative breast cancerNeutrophil extracellular trap formationT cell exclusionAnti-tumor immunityPoor clinical outcomeImmunosuppressive tumor microenvironmentMammary tumor onsetNeutrophil extracellular trapsExtracellular trap formationBreast cancer modelMurine breast tumorsClinical outcomesNeutrophil recruitmentCell infiltrationCHI3L1 expressionTumor infiltrationExtracellular trapsTranscription factor STAT3Immune responseLack of responsivenessSolid tumors