2008
Kinetic Modeling of the Assembly, Dynamic Steady State, and Contraction of the FtsZ Ring in Prokaryotic Cytokinesis
Surovtsev I, Morgan J, Lindahl P. Kinetic Modeling of the Assembly, Dynamic Steady State, and Contraction of the FtsZ Ring in Prokaryotic Cytokinesis. PLOS Computational Biology 2008, 4: e1000102. PMID: 18604268, PMCID: PMC2432035, DOI: 10.1371/journal.pcbi.1000102.Peer-Reviewed Original ResearchConceptsSame chemical modelMonomeric unitsPolymeric ringsRapid assemblyChemical modelProkaryotic cytokinesisMembrane surfaceFree energyUnfavorable processMonomeric FtsZKinetic modelingMechanistic complexityInterfacial reactionRingVivo behaviorDynamic steady stateMonomeric subunitsFtsZ polymerizationHydrolysisReactionRing formsAssembly
2007
Nickel-Dependent Oligomerization of the Alpha Subunit of Acetyl-Coenzyme A Synthase/Carbon Monoxide Dehydrogenase †
Tan X, Kagiampakis I, Surovtsev I, Demeler B, Lindahl P. Nickel-Dependent Oligomerization of the Alpha Subunit of Acetyl-Coenzyme A Synthase/Carbon Monoxide Dehydrogenase †. Biochemistry 2007, 46: 11606-11613. PMID: 17887777, PMCID: PMC2528952, DOI: 10.1021/bi7014663.Peer-Reviewed Original ResearchConceptsAlpha subunitCarbon monoxide dehydrogenaseSynthase/carbon monoxide dehydrogenaseApo-alphaHigh molecular weight speciesMolecular weight speciesRecombinant alpha subunitAcetyl-CoA synthase/carbon monoxide dehydrogenaseWeight speciesOpen conformationSulfur proteinA-clusterConformational changesSubunitsStructural scaffoldOligomerizationFe4S4 clusterSpeciesActive siteConformationDehydrogenaseInterrelated eventsActivationOligomerizesDimers
2006
Kinetics of CO Insertion and Acetyl Group Transfer Steps, and a Model of the Acetyl-CoA Synthase Catalytic Mechanism
Tan X, Surovtsev I, Lindahl P. Kinetics of CO Insertion and Acetyl Group Transfer Steps, and a Model of the Acetyl-CoA Synthase Catalytic Mechanism. Journal Of The American Chemical Society 2006, 128: 12331-12338. PMID: 16967985, PMCID: PMC2527582, DOI: 10.1021/ja0627702.Peer-Reviewed Original ResearchConceptsCO insertionCatalytic mechanismGroup transferNiFeC EPR signalAcetyl-CoA synthase/carbon monoxide dehydrogenaseEquilibrium constantsMethyl groupSynthase/carbon monoxide dehydrogenaseCO insertion stepInsertion of COCarbon monoxide dehydrogenaseSubsequent catalytic stepsActive enzyme moleculesStopped-flow methodTransfer stepIndividual equilibrium constantsInsertion stepMethyl group transferEPR signalEnzyme moleculesCatalytic stepSimple kinetic modelSulfur proteinVariation of activityRate coefficients