2000
Sex Differences in Self-Reported and Physiological Response to Oral Cocaine and Placebo in Humans
Singha A, McCance-Katz E, Petrakis I, Kosten T, Oliveto A. Sex Differences in Self-Reported and Physiological Response to Oral Cocaine and Placebo in Humans. The American Journal Of Drug And Alcohol Abuse 2000, 26: 643-657. PMID: 11097197, DOI: 10.1081/ada-100101900.Peer-Reviewed Original ResearchConceptsBad drug effectsSex differencesSystolic blood pressureCocaine-abusing volunteersGreater increasePentobarbital-ChlorpromazineBlood pressurePlacebo controlDrug effectsActive drugOral cocainePlaceboBaseline ratingsCocaineGreater ratingsMalesDrugsFemalesPhysiological responsesResponseAlcohol groupDifferencesVolunteers
1997
Effect of alpha-methyl-para-tyrosine on response to cocaine challenge
Stine S, Krystal J, Petrakis I, Jatlow P, Heninger G, Kosten T, Chamey D. Effect of alpha-methyl-para-tyrosine on response to cocaine challenge. Biological Psychiatry 1997, 42: 181-190. PMID: 9232210, DOI: 10.1016/s0006-3223(96)00331-9.Peer-Reviewed Original ResearchConceptsDopamine metabolite homovanillic acidCocaine-induced euphoriaNorepinephrine metabolite 3Placebo-controlled studyBlood pressure responseMetabolite homovanillic acidReduced plasma levelsTyrosine hydroxylase inhibitorSerum cocaine levelsTuberoinfundibular dopamine systemAMPT pretreatmentAcute reductionIntranasal administrationPara-tyrosinePlasma levelsProlactin levelsCocaine challengeHomovanillic acidCatecholamine synthesisHeart rateHydroxylase inhibitorAlpha-methylDopamine systemCocaine levelsTherapeutic potential