2024
The Impact of High-Potency Synthetic Opioids on Pharmacotherapies for Opioid Use Disorder: A Scoping Review
Jegede O, De Aquino J, Hsaio C, Caldwell E, Funaro M, Petrakis I, Muvvala S. The Impact of High-Potency Synthetic Opioids on Pharmacotherapies for Opioid Use Disorder: A Scoping Review. Journal Of Addiction Medicine 2024, 18: 499-510. PMID: 39356620, PMCID: PMC11449257, DOI: 10.1097/adm.0000000000001356.Peer-Reviewed Original ResearchNonmedical opioid useOpioid use disorderOpioid useWithdrawal symptomsTreatment outcomesSymptoms prior to treatmentUse disorderRisk of precipitated withdrawalLow-dose buprenorphineSynthetic opioidsPotency synthetic opioidsConclusions Current evidencePrecipitated withdrawalRisk of overdoseDosing strategiesPharmacological interactionsClinical significanceDecreased riskWeb of ScienceOpioidInclusion criteriaCurrent evidenceClinical implicationsMOUDPain
2020
Alcohol
Sloan M, Werner R, Yarnell-MacGrory S, Petrakis I. Alcohol. 2020, 121-137. DOI: 10.1007/978-3-030-33404-8_8.Peer-Reviewed Original ResearchAlcohol use disorderUse disordersIndirect laboratory testsWithdrawal symptomsPhysiologic dependenceClinical managementLeading causeGlutamatergic synapsesDiagnostic criteriaAlcohol consumptionAlcohol intoxicationHeavy drinkersRecent consumptionAlcohol useAltered activityRecent evidenceSymptomsLoss of controlIntoxicationSynapsesDisordersWithdrawalLaboratory testsGABAergicPharmacotherapy
2008
Alcohol Detoxification and Relapse Prevention Using Valproic Acid Versus Gabapentin in Alcohol-dependent Patients
Trevisan L, Ralevski E, Keegan K, Oville A, Vuppalapati D, Gonzalez G, Limoncelli D, Petrakis I. Alcohol Detoxification and Relapse Prevention Using Valproic Acid Versus Gabapentin in Alcohol-dependent Patients. Addictive Disorders & Their Treatment 2008, 7: 119-128. DOI: 10.1097/adt.0b013e31812e6a3c.Peer-Reviewed Original ResearchAlcohol withdrawalDays of treatmentSleep disturbancesAlcohol detoxificationModerate withdrawalValproic acidAcute alcohol withdrawalPlacebo-controlled trialMild withdrawal symptomsDoses of benzodiazepinesPrevention of relapseAlcohol-dependent patientsSymptoms of depressionPhysiologic withdrawalPostwithdrawal periodSupportive treatmentAcute symptomsBenzodiazepine medicationWithdrawal symptomsAcute withdrawalPsychiatric symptomsMale veteransClinical importancePsychiatric distressRelapse prevention