2021
Collagen type VI-α1 and 2 repress the proliferation, migration and invasion of bladder cancer cells
Piao X, Hwang B, Jeong P, Byun Y, Kang H, Seo S, Kim W, Lee J, Ha Y, Lee Y, Kim I, Choi Y, Cha E, Moon S, Yun S, Kim W. Collagen type VI-α1 and 2 repress the proliferation, migration and invasion of bladder cancer cells. International Journal Of Oncology 2021, 59: 37. PMID: 33982770, DOI: 10.3892/ijo.2021.5217.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overCell Line, TumorCell MovementCell ProliferationCollagen Type VIG1 Phase Cell Cycle CheckpointsGene Expression Regulation, NeoplasticHumansMiddle AgedP38 Mitogen-Activated Protein KinasesPhosphorylationProto-Oncogene Proteins c-aktSignal TransductionTranscription FactorsUrinary Bladder NeoplasmsConceptsNon-muscle invasive BCaExtracellular matrixMRNA expressionEJ cellsBladder cancer microenvironmentTissue samplesHeterogeneous tumor cell populationsCell cycle arrestReverse transcription-quantitative PCRTumor-suppressive effectsBladder cancer cellsP38 MAPK phosphorylationTranscription-quantitative PCRCollagen typesRisk stratificationInvasive BCaTumor infiltrationTumor cell populationBCa pathogenesisMMP-9MAPK phosphorylationAkt phosphorylationCycle arrestNormal controlsMatrix metalloproteinase
2017
Garlic extract in bladder cancer prevention: Evidence from T24 bladder cancer cell xenograft model, tissue microarray, and gene network analysis
Kim W, Seo S, Byun Y, Kang H, Kim Y, Lee S, Jeong P, Seo Y, Choe S, Kim D, Kim S, Moon S, Choi Y, Lee G, Kim I, Yun S, Kim W. Garlic extract in bladder cancer prevention: Evidence from T24 bladder cancer cell xenograft model, tissue microarray, and gene network analysis. International Journal Of Oncology 2017, 51: 204-212. PMID: 28498422, DOI: 10.3892/ijo.2017.3993.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApoptosisBiomarkers, TumorCell ProliferationGarlicGene Expression Regulation, NeoplasticGene Regulatory NetworksHumansMaleMiceMice, Inbred BALB CMice, NudePlant ExtractsSignal TransductionTissue Array AnalysisTumor Cells, CulturedUrinary Bladder NeoplasmsXenograft Model Antitumor AssaysConceptsCancer preventionBladder cancerGarlic extractXenograft modelNude mouse xenograft modelAcceptable safety profileBladder cancer preventionCancer prevention activitiesCell xenograft modelBALB/cTissue microarray analysisMouse xenograft modelMicroarray analysisTumor weightBC patientsSafety profileTumor volumeTissue microarrayControl groupGene network analysisControl dietPrevention activitiesPreventionExtract intakePotential mechanismsIntracrine androgen biosynthesis in renal cell carcinoma
Lee G, Han C, Kwon Y, Patel R, Modi P, Kwon S, Faiena I, Patel N, Singer E, Ahn H, Kim W, Kim I. Intracrine androgen biosynthesis in renal cell carcinoma. British Journal Of Cancer 2017, 116: 937-943. PMID: 28253524, PMCID: PMC5379152, DOI: 10.1038/bjc.2017.42.Peer-Reviewed Original ResearchMeSH KeywordsAbiraterone AcetateAndrogensAnimalsAntineoplastic AgentsApoptosisBenzamidesBlotting, WesternCarcinoma, Renal CellCell ProliferationDihydrotestosteroneFemaleHumansImmunoenzyme TechniquesKidney NeoplasmsMaleMiceMice, NudeNitrilesOrchiectomyPhenylthiohydantoinPrognosisProstatic NeoplasmsProstatic Neoplasms, Castration-ResistantReal-Time Polymerase Chain ReactionReceptors, AndrogenReverse Transcriptase Polymerase Chain ReactionRNA, MessengerTestosteroneTumor Cells, CulturedXenograft Model Antitumor AssaysConceptsRenal cell carcinomaCastration-resistant prostate cancerRCC cell linesAnti-androgen therapyHuman RCC cell linesAndrogen biosynthesisAbiraterone acetateCell carcinomaAndrogen receptorTumor volumeCell linesAndrogen deprivation therapyHigher tumor stageProstate cancer patientsMouse xenograft studiesGenitourinary cancersTumor suppressionSignificant tumor suppressionRCC patientsTumor stageCancer patientsMale miceProstate cancerIntratumoral steroidogenesisXenograft studies
2016
BMI-1 Targeting Interferes with Patient-Derived Tumor-Initiating Cell Survival and Tumor Growth in Prostate Cancer
Bansal N, Bartucci M, Yusuff S, Davis S, Flaherty K, Huselid E, Patrizii M, Jones D, Cao L, Sydorenko N, Moon Y, Zhong H, Medina D, Kerrigan J, Stein M, Kim I, Davis T, DiPaola R, Bertino J, Sabaawy H. BMI-1 Targeting Interferes with Patient-Derived Tumor-Initiating Cell Survival and Tumor Growth in Prostate Cancer. Clinical Cancer Research 2016, 22: 6176-6191. PMID: 27307599, PMCID: PMC5159329, DOI: 10.1158/1078-0432.ccr-15-3107.Peer-Reviewed Original ResearchConceptsTumor-initiating cellsProstate tumor-initiating cellsBmi-1Androgen receptor-directed therapyIntrinsic therapy resistanceReceptor-directed therapyProstate cancer managementProstate cancer treatmentMore effective therapiesBmi-1 expressionProstate cancer cellsStem cell-like traitsSelf-renewing tumor-initiating cellsCell-like traitsPatient-derived cellsEffective therapyTumor relapseCancer managementXenograft modelTherapy resistancePharmacologic inhibitionBmi-1 functionTherapyNormal tissuesCancer treatment
2014
DHCR24 is an Independent Predictor of Progression in Patients with Non-Muscle-Invasive Urothelial Carcinoma, and Its Functional Role is Involved in the Aggressive Properties of Urothelial Carcinoma Cells
Lee G, Ha Y, Jung Y, Moon S, Kang H, Lee O, Joung J, Choi Y, Yun S, Kim W, Kim I. DHCR24 is an Independent Predictor of Progression in Patients with Non-Muscle-Invasive Urothelial Carcinoma, and Its Functional Role is Involved in the Aggressive Properties of Urothelial Carcinoma Cells. Annals Of Surgical Oncology 2014, 21: 538-545. PMID: 24562935, DOI: 10.1245/s10434-014-3560-6.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overAndrostenesCarcinomaCell AdhesionCell Line, TumorCell MovementCell ProliferationCell SurvivalDisease ProgressionDisease-Free SurvivalFemaleGene ExpressionGene Knockdown TechniquesHumansMaleMiddle AgedNeoplasm InvasivenessNerve Tissue ProteinsOxidoreductases Acting on CH-CH Group DonorsRNA, MessengerUrinary Bladder NeoplasmsYoung AdultConceptsUrothelial carcinoma cellsMRNA expression levelsIndependent predictorsUrothelial carcinomaImmunohistochemical stainingNon-muscle invasive urothelial carcinomaMultivariate Cox regression analysisCarcinoma cellsHuman UC cellsCox regression analysisKaplan-Meier estimatesInvasive urothelial carcinomaAggressive propertiesHuman urothelial carcinoma cellsExpression levelsProgression-related genesDHCR24 expressionExpression groupFunctional roleClinical relevanceGene signaturePatientsUC cellsProgressionHigh grade
2013
Mechanism of pro‐tumorigenic effect of BMP‐6: Neovascularization involving tumor‐associated macrophages and IL‐1α
Kwon S, Lee G, Lee J, Iwakura Y, Kim W, Kim I. Mechanism of pro‐tumorigenic effect of BMP‐6: Neovascularization involving tumor‐associated macrophages and IL‐1α. The Prostate 2013, 74: 121-133. PMID: 24185914, DOI: 10.1002/pros.22734.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBone Morphogenetic Protein 6CarcinogenesisCell DifferentiationCell Line, TumorCell ProliferationCoculture TechniquesEndothelium, VascularHumansInterleukin-1alphaMacrophagesMaleMiceMice, Inbred C57BLMice, KnockoutNeovascularization, PathologicNF-kappa BProstatic NeoplasmsSignal TransductionSmad1 ProteinConceptsBone morphogenetic protein 6Prostate cancer growthTumor-associated macrophagesIL-1APro-tumorigenic effectsCancer growthHuman prostate cancer cell linesHuman prostate cancer tissuesLNCaP human prostate cancer cell lineProstate cancer cell linesTube formationProstate cancer tissuesTHP-1 cellsEndothelial tube formationCancer cell linesIL-1αProstate cancerKnockout miceCD11b-DTRCancer tissuesTumor growthNF-kB1Endothelial cellsMacrophagesConditioned mediaBMP-6 in Renal Cell Carcinoma Promotes Tumor Proliferation through IL-10–Dependent M2 Polarization of Tumor-Associated Macrophages
Lee J, Lee G, Woo S, Ha Y, Kwon S, Kim W, Kim I. BMP-6 in Renal Cell Carcinoma Promotes Tumor Proliferation through IL-10–Dependent M2 Polarization of Tumor-Associated Macrophages. Cancer Research 2013, 73: 3604-3614. PMID: 23633487, DOI: 10.1158/0008-5472.can-12-4563.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBone Morphogenetic Protein 6Carcinoma, Renal CellCell LineCell Line, TumorCell ProliferationClodronic AcidDoxycyclineHumansImmunoblottingInterleukin-10Kaplan-Meier EstimateKidney NeoplasmsMacrophagesMiceMice, Inbred BALB CMice, KnockoutMicroscopy, FluorescenceReverse Transcriptase Polymerase Chain ReactionRNA InterferenceSmad5 ProteinSTAT3 Transcription FactorTumor Burden
2006
Expression of estrogen receptors‐α and ‐β in bladder cancer cell lines and human bladder tumor tissue
Shen S, Smith C, Hsieh J, Yu J, Kim I, Jian W, Sonpavde, Ayala G, Younes M, Lerner S. Expression of estrogen receptors‐α and ‐β in bladder cancer cell lines and human bladder tumor tissue. Cancer 2006, 106: 2610-2616. PMID: 16700038, DOI: 10.1002/cncr.21945.Peer-Reviewed Original ResearchMeSH KeywordsAntineoplastic AgentsBlotting, WesternCarcinoma, Transitional CellCell Line, TumorCell ProliferationEstradiolEstrogen Receptor alphaEstrogen Receptor betaFulvestrantGene Expression ProfilingGene Expression Regulation, NeoplasticHumansImmunohistochemistryMicroarray AnalysisNeoplasm StagingRaloxifene HydrochlorideReverse Transcriptase Polymerase Chain ReactionRNA, MessengerTamoxifenUrinary Bladder NeoplasmsConceptsBladder cancer cell linesExpression of ERbetaCancer cell linesERbeta expressionHuman bladder cancerBladder cancer cellsBladder cancerEstrogen receptorWestern blot analysisT4 tumorsCell linesMetastatic transitional cell carcinomaMuscle-invasive bladder cancerER-alpha mRNA levelsT3/T4 tumorsHuman bladder tumor tissuesRT4 cellsBladder cancer cell growthLevels of ERalphaGrade 3 tumorsCancer cellsInvasive bladder cancerTa/T1Transitional cell carcinomaEffects of estradiol