2022
Survival of nonseminomatous germ cell tumors in pediatric patients and young adults – A stage group stratified analysis
Srivastava A, Patel H, Koehne E, Gupta G, Drachtman R, Pierorazio P, Bagrodia A, Elsamra S, Kim I, Ghodoussipour S, Singer E, Jang T, Patel H, Barone J. Survival of nonseminomatous germ cell tumors in pediatric patients and young adults – A stage group stratified analysis. Urologic Oncology Seminars And Original Investigations 2022, 40: 169.e1-169.e12. PMID: 35144865, PMCID: PMC8960351, DOI: 10.1016/j.urolonc.2021.12.012.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedChildHumansMaleNeoplasm StagingNeoplasms, Germ Cell and EmbryonalProportional Hazards ModelsRetrospective StudiesSurvival AnalysisTesticular NeoplasmsYoung AdultConceptsNonseminomatous germ cell tumorsCancer-specific survivalGerm cell tumorsCell tumorsStage groupPediatric patientsAdolescent patientsYoung adultsStage IAdvanced nonseminomatous germ cell tumorsSurvival analysisAge groupsWorse cancer-specific survivalCox proportional hazards modelTesticular germ cell tumorsEnd Results (SEER) databaseExcellent survival outcomesStage III tumorsExcellent oncologic outcomesImportant prognostic factorKaplan-Meier curvesCommon solid malignancyProportional hazards modelNSGCT patientsOncologic outcomes
2013
HOXA9, ISL1 and ALDH1A3 methylation patterns as prognostic markers for nonmuscle invasive bladder cancer: Array‐based DNA methylation and expression profiling
Kim Y, Yoon H, Kim J, Kang H, Min B, Kim S, Ha Y, Kim I, Ryu K, Lee S, Kim W. HOXA9, ISL1 and ALDH1A3 methylation patterns as prognostic markers for nonmuscle invasive bladder cancer: Array‐based DNA methylation and expression profiling. International Journal Of Cancer 2013, 133: 1135-1142. PMID: 23436614, DOI: 10.1002/ijc.28121.Peer-Reviewed Original ResearchConceptsISL LIM homeobox 1Novel methylation markersDNA methylationNonmuscle invasive bladder cancerMethylation patternsHomeobox A9DNA methylation patternsInvasive bladder cancerDecreased gene expression levelsLIM homeobox 1RNA expression patternsGene expression profilesAldehyde dehydrogenase 1 familyGene expression levelsMethylation markersNMIBC patientsDisease recurrenceBladder cancerExpression profilingExpression patternsExpression profilesMicroarray analysisNormal controlsPyrosequencing analysisHomeobox 1
2012
Ras Association Domain Family 1A: A Promising Prognostic Marker in Recurrent Nonmuscle Invasive Bladder Cancer
Kim J, Chae Y, Ha Y, Kim I, Byun S, Yun S, Kim W. Ras Association Domain Family 1A: A Promising Prognostic Marker in Recurrent Nonmuscle Invasive Bladder Cancer. Clinical Genitourinary Cancer 2012, 10: 114-120. PMID: 22382007, DOI: 10.1016/j.clgc.2011.12.003.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overBiomarkers, TumorCarcinoma, Transitional CellChildDNA MethylationFemaleHumansKaplan-Meier EstimateMaleMiddle AgedMultivariate AnalysisNeoplasm InvasivenessNeoplasm Recurrence, LocalNeoplasm StagingPrognosisPromoter Regions, GeneticProportional Hazards ModelsTumor BurdenTumor Suppressor ProteinsUrinary Bladder NeoplasmsYoung AdultConceptsRecurrent nonmuscle invasive bladder cancerNonmuscle invasive bladder cancerMuscle-invasive bladder cancerInvasive bladder cancerPrimary BC tissuesCox regression analysisBladder cancerPrognostic markerRASSF1A methylationRASSF1A hypermethylationIndependent predictorsBC tissuesMultivariate Cox regression analysisCancer progressionKaplan-Meier analysisAdvanced tumor stagePromising prognostic markerPromoter hypermethylationPotential prognostic markerRegression analysisRASSF1A promoter hypermethylationMethylation-specific polymerase chain reactionClinicopathologic featuresPrognostic significanceKaplan-Meier
2011
GSTM1 Tissue Genotype as a Recurrence Predictor in Non-muscle Invasive Bladder Cancer
Ha Y, Yan C, Jeong P, Kim W, Yun S, Kim I, Moon S, Kim W. GSTM1 Tissue Genotype as a Recurrence Predictor in Non-muscle Invasive Bladder Cancer. Journal Of Korean Medical Science 2011, 26: 231-236. PMID: 21286014, PMCID: PMC3031007, DOI: 10.3346/jkms.2011.26.2.231.Peer-Reviewed Original ResearchMeSH KeywordsAgedBiomarkers, TumorGenotypeGlutathione TransferaseHumansIsoenzymesKaplan-Meier EstimateMiddle AgedPrognosisProportional Hazards ModelsRecurrenceUrinary Bladder NeoplasmsConceptsNon-muscle invasive bladder cancerInvasive bladder cancerTumor recurrencePolymerase chain reactionTissue genotypeBladder cancerMultivariate Cox regression analysisGlutathione S-transferaseCox regression analysisGlutathione S-transferase muCox regression modelKaplan-Meier estimatesBladder tumor recurrencePrognosis of BCBladder cancer developmentBC tissue samplesGlutathione S-transferase thetaTissue genotypingIndependent predictorsPrognostic significanceKaplan-MeierBlood genomic DNAClinicopathological parametersRecurrence predictorsGSTM1 genotype
2010
HMOX1 is an Important Prognostic Indicator of Nonmuscle Invasive Bladder Cancer Recurrence and Progression
Yim M, Ha Y, Kim I, Yun S, Choi Y, Kim W. HMOX1 is an Important Prognostic Indicator of Nonmuscle Invasive Bladder Cancer Recurrence and Progression. Journal Of Urology 2010, 185: 701-705. PMID: 21168882, DOI: 10.1016/j.juro.2010.09.081.Peer-Reviewed Original ResearchAgedBiomarkers, TumorBiopsy, NeedleCarcinoma, Transitional CellCohort StudiesCystectomyDisease ProgressionFemaleGene Expression Regulation, NeoplasticHeme Oxygenase-1HumansImmunohistochemistryKaplan-Meier EstimateMaleMiddle AgedMultivariate AnalysisNeoplasm InvasivenessNeoplasm Recurrence, LocalPrognosisProportional Hazards ModelsReverse Transcriptase Polymerase Chain ReactionRNA, MessengerSensitivity and SpecificitySurvival AnalysisUrinary Bladder NeoplasmsAnalysis of hOGG1 genotype as a prognostic marker for muscle invasive bladder cancer: A novel approach using peptide nucleic acid-mediated, real-time PCR clamping
Kim E, Yan C, Ha Y, Jeong P, Kim I, Moon S, Choi Y, Kim W. Analysis of hOGG1 genotype as a prognostic marker for muscle invasive bladder cancer: A novel approach using peptide nucleic acid-mediated, real-time PCR clamping. Urologic Oncology Seminars And Original Investigations 2010, 30: 673-679. PMID: 20884250, DOI: 10.1016/j.urolonc.2010.07.008.Peer-Reviewed Original ResearchMeSH KeywordsAgedBiomarkers, TumorDNA GlycosylasesFemaleGene FrequencyGenotypeHumansKaplan-Meier EstimateMaleMiddle AgedMultivariate AnalysisMusclesNeoplasm GradingNeoplasm InvasivenessNeoplasm StagingPeptide Nucleic AcidsPolymerase Chain ReactionPolymorphism, GeneticPrognosisProportional Hazards ModelsUrinary Bladder NeoplasmsConceptsMuscle-invasive bladder cancerReal-time PCR clampingInvasive bladder cancerBladder cancerHOGG1 genotypeHOGG1 codon 326 genotypesMultivariate Cox regression analysisHOGG1 codon 326Cancer-specific survivalCox regression analysisPrognostic genetic markersPCR clampingSpecific survivalSurvival benefitClinicopathologic characteristicsBC patientsPrognostic indicatorTumor gradePrognostic markerClinical dataProtective effectCancerPatientsDNA damage repair mechanismsCodon 326