2021
Collagen type VI-α1 and 2 repress the proliferation, migration and invasion of bladder cancer cells
Piao X, Hwang B, Jeong P, Byun Y, Kang H, Seo S, Kim W, Lee J, Ha Y, Lee Y, Kim I, Choi Y, Cha E, Moon S, Yun S, Kim W. Collagen type VI-α1 and 2 repress the proliferation, migration and invasion of bladder cancer cells. International Journal Of Oncology 2021, 59: 37. PMID: 33982770, DOI: 10.3892/ijo.2021.5217.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overCell Line, TumorCell MovementCell ProliferationCollagen Type VIG1 Phase Cell Cycle CheckpointsGene Expression Regulation, NeoplasticHumansMiddle AgedP38 Mitogen-Activated Protein KinasesPhosphorylationProto-Oncogene Proteins c-aktSignal TransductionTranscription FactorsUrinary Bladder NeoplasmsConceptsNon-muscle invasive BCaExtracellular matrixMRNA expressionEJ cellsBladder cancer microenvironmentTissue samplesHeterogeneous tumor cell populationsCell cycle arrestReverse transcription-quantitative PCRTumor-suppressive effectsBladder cancer cellsP38 MAPK phosphorylationTranscription-quantitative PCRCollagen typesRisk stratificationInvasive BCaTumor infiltrationTumor cell populationBCa pathogenesisMMP-9MAPK phosphorylationAkt phosphorylationCycle arrestNormal controlsMatrix metalloproteinase
2002
Raloxifene, a Mixed Estrogen Agonist/Antagonist, Induces Apoptosis through Cleavage of BAD in TSU-PR1 Human Cancer Cells*
Kim H, Kim B, Kim I, Mamura M, Do Hwan Seong, Jang J, Kim S. Raloxifene, a Mixed Estrogen Agonist/Antagonist, Induces Apoptosis through Cleavage of BAD in TSU-PR1 Human Cancer Cells*. Journal Of Biological Chemistry 2002, 277: 32510-32515. PMID: 12084714, DOI: 10.1074/jbc.m202852200.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid Chloromethyl KetonesAntineoplastic AgentsApoptosisBcl-Associated Death ProteinBcl-X ProteinCarrier ProteinsCaspase 3CaspasesCell DivisionCell MembraneCell NucleusCycloheximideCytochrome c GroupDNA FragmentationDose-Response Relationship, DrugEstrogen Receptor ModulatorsHumansIn Situ Nick-End LabelingMembrane PotentialsMitochondriaPhosphorylationProtein BindingProtein Synthesis InhibitorsProto-Oncogene Proteins c-bcl-2Raloxifene HydrochlorideRetroviridaeTime FactorsTumor Cells, CulturedUrinary Bladder NeoplasmsConceptsMixed estrogen agonist/antagonistTSU-Pr1 cell linesEstrogen agonist/antagonistTSU-Pr1 cellsAgonists/antagonistsCell linesSelective estrogen receptor modulatorsHuman bladder transitional cell carcinoma cell lineEffects of raloxifeneTransitional cell carcinoma cell linesProstate cancer cell linesEstrogen receptor modulatorsCell carcinoma cell linesEstrogen receptor betaHuman bladder cancerDose-dependent mannerEvidence of apoptosisCancer cell linesRaloxifene treatmentCarcinoma cell linesBladder cancerReceptor modulatorsBreast cancerHuman cancer cellsRaloxifene