2018
Role of the androgen signaling axis in genitourinary malignancies.
Shinder B, Shupe A, Lee G, Stein M, Kim I, Singer E. Role of the androgen signaling axis in genitourinary malignancies. Translational Cancer Research 2018, 7: 1135-1142. PMID: 30701159, PMCID: PMC6349041, DOI: 10.21037/tcr.2018.03.41.Peer-Reviewed Original ResearchRenal cell carcinomaGenitourinary malignanciesAndrogen receptorBladder cancerRole of ARAdvanced disease stateProstate cancer developmentNovel therapeutic strategiesCell carcinomaTherapeutic armamentariumTherapeutic strategiesMortality rateCancer developmentMalignancyAndrogensDisease statesCancerCarcinomaProstateArmamentariumMolecular biologyDiseaseProgressionRoleReceptors
2014
DHCR24 is an Independent Predictor of Progression in Patients with Non-Muscle-Invasive Urothelial Carcinoma, and Its Functional Role is Involved in the Aggressive Properties of Urothelial Carcinoma Cells
Lee G, Ha Y, Jung Y, Moon S, Kang H, Lee O, Joung J, Choi Y, Yun S, Kim W, Kim I. DHCR24 is an Independent Predictor of Progression in Patients with Non-Muscle-Invasive Urothelial Carcinoma, and Its Functional Role is Involved in the Aggressive Properties of Urothelial Carcinoma Cells. Annals Of Surgical Oncology 2014, 21: 538-545. PMID: 24562935, DOI: 10.1245/s10434-014-3560-6.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overAndrostenesCarcinomaCell AdhesionCell Line, TumorCell MovementCell ProliferationCell SurvivalDisease ProgressionDisease-Free SurvivalFemaleGene ExpressionGene Knockdown TechniquesHumansMaleMiddle AgedNeoplasm InvasivenessNerve Tissue ProteinsOxidoreductases Acting on CH-CH Group DonorsRNA, MessengerUrinary Bladder NeoplasmsYoung AdultConceptsUrothelial carcinoma cellsMRNA expression levelsIndependent predictorsUrothelial carcinomaImmunohistochemical stainingNon-muscle invasive urothelial carcinomaMultivariate Cox regression analysisCarcinoma cellsHuman UC cellsCox regression analysisKaplan-Meier estimatesInvasive urothelial carcinomaAggressive propertiesHuman urothelial carcinoma cellsExpression levelsProgression-related genesDHCR24 expressionExpression groupFunctional roleClinical relevanceGene signaturePatientsUC cellsProgressionHigh grade
2013
1865 S100A9 AND EGFR GENE SIGNATURES PREDICT DISEASE PROGRESSION IN BLADDER CANCER PATIENTS AFTER CHEMOTHERAPY
Kim W, Yun S, Kim Y, Kim T, Seo J, Cho I, Ha Y, Kim I, Lee S, Kim W. 1865 S100A9 AND EGFR GENE SIGNATURES PREDICT DISEASE PROGRESSION IN BLADDER CANCER PATIENTS AFTER CHEMOTHERAPY. Journal Of Urology 2013, 189: e764-e765. DOI: 10.1016/j.juro.2013.02.2284.Peer-Reviewed Original Research
2011
Novel combination markers for predicting progression of nonmuscle invasive bladder cancer
Ha Y, Kim J, Yoon H, Jeong P, Kim T, Yun S, Lee S, Kim G, Choi Y, Moon S, Kim I, Kim W. Novel combination markers for predicting progression of nonmuscle invasive bladder cancer. International Journal Of Cancer 2011, 131: e501-e507. PMID: 22025348, DOI: 10.1002/ijc.27319.Peer-Reviewed Original ResearchConceptsNonmuscle invasive bladder cancerInvasive bladder cancerMethylation-specific polymerase chain reactionBladder cancerNMIBC progressionMultivariate Cox regression analysisPredictive combinationCox regression analysisKaplan-Meier estimatesMRNA expression levelsBest predictive combinationMedian followRUNX3 promoter methylationIntravesical therapyPrognostic effectSpecific polymerase chain reactionSubgroup analysisEffect of RUNX3Prognostic markerReal-time PCRHigh riskCombination markersPatientsMRNA expressionProgression