2014
Comparison of mRNA, Protein, and Urinary Nucleic Acid Levels of S100A8 and S100A9 between Prostate Cancer and BPH
Yun S, Yan C, Jeong P, Kang H, Kim Y, Kim E, Lee O, Kim W, Moon S, Kim I, Choi Y, Kim W. Comparison of mRNA, Protein, and Urinary Nucleic Acid Levels of S100A8 and S100A9 between Prostate Cancer and BPH. Annals Of Surgical Oncology 2014, 22: 2439-2445. PMID: 25348783, DOI: 10.1245/s10434-014-4194-4.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overBiomarkers, TumorCalgranulin ACalgranulin BCase-Control StudiesFollow-Up StudiesHumansImmunoenzyme TechniquesMaleMiddle AgedNeoplasm GradingNeoplasm Recurrence, LocalNeoplasm StagingNucleic AcidsPrognosisProstatic HyperplasiaProstatic NeoplasmsReal-Time Polymerase Chain ReactionReverse Transcriptase Polymerase Chain ReactionRNA, MessengerSurvival RateConceptsS100A8/A9CAP patientsAcid levelsNucleic acid levelBPH tissueProstate cancerS100A8/A9 expressionBenign prostatic hyperplasia tissuesRecurrence-free timeProstatic hyperplasia tissuesUrinary nucleic acidsBPH patientsIndependent predictorsTransurethral resectionAggressive diseaseChronic inflammationPoor prognosisPrognostic valueTransurethral prostatectomyProstatectomy patientsBiochemical recurrencePrognostic markerS100A9 expressionA9 expressionImmunohistochemical staining
2013
Decreased DBC1 Expression Is Associated With Poor Prognosis in Patients With Non-Muscle-Invasive Bladder Cancer
Shim U, Lee I, Kang H, Kim J, Kim W, Kim I, Ryu K, Choi Y, Moon S, Kim Y, Yun S, Lee S, Kim W. Decreased DBC1 Expression Is Associated With Poor Prognosis in Patients With Non-Muscle-Invasive Bladder Cancer. Investigative And Clinical Urology 2013, 54: 631-637. PMID: 24044099, PMCID: PMC3773595, DOI: 10.4111/kju.2013.54.9.631.Peer-Reviewed Original ResearchBladder cancerDBC1 expressionExpression of DBC1Prognostic valuePrognostic markerNon-muscle invasive bladder cancerMultivariate Cox regression analysisMultivariate Cox regression modelCancer-specific survivalCox regression analysisKaplan-Meier analysisPredictors of progressionCox regression modelKaplan-Meier estimatesUseful prognostic markerAggressive tumor characteristicsNormal bladder mucosaPolymerase chain reaction analysisTumor characteristicsPoor prognosisTumor recurrenceReal-time polymerase chain reaction analysisBladder mucosaClinicopathologic parametersNMIBC
2012
Tumorigenic and Prognostic Significance of RASSF1A Expression in Low-grade (WHO Grade 1 and Grade 2) Nonmuscle-invasive Bladder Cancer
Ha Y, Jeong P, Kim J, Kwon W, Kim I, Yun S, Kim G, Choi Y, Moon S, Kim W. Tumorigenic and Prognostic Significance of RASSF1A Expression in Low-grade (WHO Grade 1 and Grade 2) Nonmuscle-invasive Bladder Cancer. Urology 2012, 79: 1411.e1-1411.e6. PMID: 22446336, DOI: 10.1016/j.urology.2012.01.042.Peer-Reviewed Original ResearchConceptsLow-grade nonmuscle-invasive bladder cancersNonmuscle invasive bladder cancerPolymerase chain reactionBladder cancerTumor tissueMultivariate Cox regression analysisMRNA expressionTissue levelsRASSF1A expressionCox regression analysisKaplan-Meier estimatesChain reactionNormal bladder mucosaTumor tissue levelsNormal tissue levelsReal-time polymerase chain reactionRASSF1A promoter methylationQuantitative real-time polymerase chain reactionMethylation-specific polymerase chain reactionEffect of RASSF1AT ratioIndependent predictorsPrognostic significancePrognostic valueLarge tumors
2011
Three-gene signature predicts disease progression of non-muscle invasive bladder cancer.
Jeong P, Ha Y, Cho I, Yun S, Yoo E, Kim I, Choi Y, Moon S, Kim W. Three-gene signature predicts disease progression of non-muscle invasive bladder cancer. Oncology Letters 2011, 2: 679-684. PMID: 22848249, PMCID: PMC3406413, DOI: 10.3892/ol.2011.309.Peer-Reviewed Original ResearchNon-muscle invasive bladder cancerThree-gene signatureInvasive bladder cancerBladder cancerProgression of NMIBCThree-gene risk signatureMultivariate Cox regression modelMultivariate Cox regression analysisHigh-risk signaturePrevious study populationCox regression analysisKaplan-Meier methodCox regression modelKaplan-Meier estimatesBladder tumor progressionIndependent predictorsPrognostic valueDisease progressionTreatment outcomesClinical gradeRisk signatureStudy populationRisk scoreNew casesTumor progressionA Four-Gene Signature Predicts Disease Progression in Muscle Invasive Bladder Cancer
Kim W, Kim S, Jeong P, Yun S, Cho I, Kim I, Moon S, Um H, Choi Y. A Four-Gene Signature Predicts Disease Progression in Muscle Invasive Bladder Cancer. Molecular Medicine 2011, 17: 478-485. PMID: 21308147, PMCID: PMC3105150, DOI: 10.2119/molmed.2010.00274.Peer-Reviewed Original ResearchConceptsMuscle-invasive bladder cancerFour-gene signatureInvasive bladder cancerDisease progressionMIBC patientsMIBC progressionBladder cancerIndependent cohortMultivariate Cox regression analysisCox regression analysisReal-time reverse transcriptase-polymerase chain reactionReverse transcriptase-polymerase chain reactionTranscriptase-polymerase chain reactionGene expression signaturesIndependent predictorsPatient survivalPrognostic valuePromising diagnostic toolPolymerase chain reactionHigh riskPredictive valueMicroarray gene expression profilingImportant mediatorPatientsGene expression profiling
2004
Loss of expression of bone morphogenetic protein receptor type II in human prostate cancer cells
Kim I, Lee D, Lee D, Ahn H, Kim M, Kim S, Morton R. Loss of expression of bone morphogenetic protein receptor type II in human prostate cancer cells. Oncogene 2004, 23: 7651-7659. PMID: 15354178, DOI: 10.1038/sj.onc.1207924.Peer-Reviewed Original ResearchConceptsBone morphogenetic proteinProstate cancer cellsHuman prostate cancer cellsLoss of expressionProstate cancer patientsBMP-RIICancer patientsGleason scoreBMP receptor type IABone morphogenetic protein receptor type IICancer cellsSignificant associationHuman prostate cancer cell linesBiochemical recurrence-free rateExpression of BMPRsRecurrence-free rateProstate cancer cell linesCell linesTumor growth rateReceptor type IIParental cell lineCancer cell linesMorphogenetic proteinsClinical stagePrognostic value
1998
Loss of expression of transforming growth factor-beta receptors is associated with poor prognosis in prostate cancer patients.
Kim I, Ahn H, Lang S, Oefelein M, Oyasu R, Kozlowski J, Lee C. Loss of expression of transforming growth factor-beta receptors is associated with poor prognosis in prostate cancer patients. Clinical Cancer Research 1998, 4: 1625-30. PMID: 9676836.Peer-Reviewed Original ResearchConceptsHuman prostate cancer tissuesClinical tumor stageProstate cancer patientsProstate cancer tissuesGleason scoreLoss of expressionTGF-betaRIRecurrence rateTumor stageCancer patientsRadical prostatectomyCancer tissuesSurvival rateSignificant associationPotential prognostic valuePotential prognostic markerReceptor type IGrowth factor betaGrowth factor beta receptorTGF-beta receptorsInitial diagnosisPoor prognosisPrognostic valueDisease progressionPrognostic marker