2018
Diagnostic value of combined IQGAP3/BMP4 and IQGAP3/FAM107A expression ratios in urinary cell-free DNA for discriminating bladder cancer from hematuria
Xu Y, Kim Y, Jeong P, Piao X, Byun Y, Kang H, Kim W, Lee J, Kim I, Moon S, Choi Y, Yun S, Kim W. Diagnostic value of combined IQGAP3/BMP4 and IQGAP3/FAM107A expression ratios in urinary cell-free DNA for discriminating bladder cancer from hematuria. Urologic Oncology Seminars And Original Investigations 2018, 37: 86-96. PMID: 30446454, DOI: 10.1016/j.urolonc.2018.10.023.Peer-Reviewed Original ResearchConceptsBladder cancerUrinary cell-free DNACell-free DNAScreening groupHematuria patientsValidation cohortPredictive valueUrine-based markersNegative predictive valuePositive predictive valueGood diagnostic performanceStudy cohortBC patientsUrological cancersNoninvasive biomarkersPatientsScore indexDiagnostic valueHematuriaExpression level ratioLiquid biopsyCohortDiagnostic performanceCancerDS-index
2016
Accuracy of Multiparametric Magnetic Resonance Imaging for Extracapsular Extension of Prostate Cancer in Community Practice
Davis R, Salmasi A, Koprowski C, Kim S, Kwon Y, Faiena I, Patel N, Elsamra S, Kim I. Accuracy of Multiparametric Magnetic Resonance Imaging for Extracapsular Extension of Prostate Cancer in Community Practice. Clinical Genitourinary Cancer 2016, 14: e617-e622. PMID: 27188968, DOI: 10.1016/j.clgc.2016.04.010.Peer-Reviewed Original ResearchConceptsExtracapsular extensionProstate cancerRadical prostatectomyMp-MRINegative predictive valuePositive predictive valuePredictive valuePartin tablesMultiparametric magnetic resonance imagingNerve-sparing approachPreoperative mp-MRID'Amico risk groupsLarge referral centerHigh-risk groupDatabase of menMagnetic resonance imagingReferral centerStaging modalitiesD'Amico criteriaFusion biopsyOverall prevalenceRisk groupsMultiparametric MRISurgeon's decisionResonance imaging
2014
The predictive value of polymorphisms in predicting the early response to induction BCG therapy in patients with non–muscle invasive bladder cancer
Kang H, Tchey D, Yan C, Kim W, Kim Y, Yun S, Lee S, Choi Y, Kim I, Kim W. The predictive value of polymorphisms in predicting the early response to induction BCG therapy in patients with non–muscle invasive bladder cancer. Urologic Oncology Seminars And Original Investigations 2014, 32: 458-465. PMID: 24411789, DOI: 10.1016/j.urolonc.2013.10.013.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overBCG VaccineCarcinoma, Transitional CellFemaleFollow-Up StudiesGenotypeGlutathione TransferaseHumansMaleMiddle AgedNeoplasm GradingNeoplasm InvasivenessNeoplasm Recurrence, LocalNeoplasm StagingPolymerase Chain ReactionPolymorphism, GeneticPrognosisRisk FactorsSmokingSurvival RateUrinary Bladder NeoplasmsConceptsNon-muscle invasive bladder cancerGSTT1-positive genotypeInvasive bladder cancerPrimary non-muscle invasive bladder cancerBCG failureBladder cancerPredictive valueInduction therapyIndependent predictorsHigh riskBacillus Calmette-Guérin induction therapyNull genotypeMultivariate logistic regression analysisMultivariate logistic regression modelBCG induction therapyInduction BCG therapySingle induction courseDisease-free survivalGlutathione S-transferase muKaplan-Meier analysisHigh-risk groupKaplan-Meier estimatesEarly responseLogistic regression analysisGSTT1 null genotype
2011
A Four-Gene Signature Predicts Disease Progression in Muscle Invasive Bladder Cancer
Kim W, Kim S, Jeong P, Yun S, Cho I, Kim I, Moon S, Um H, Choi Y. A Four-Gene Signature Predicts Disease Progression in Muscle Invasive Bladder Cancer. Molecular Medicine 2011, 17: 478-485. PMID: 21308147, PMCID: PMC3105150, DOI: 10.2119/molmed.2010.00274.Peer-Reviewed Original ResearchConceptsMuscle-invasive bladder cancerFour-gene signatureInvasive bladder cancerDisease progressionMIBC patientsMIBC progressionBladder cancerIndependent cohortMultivariate Cox regression analysisCox regression analysisReal-time reverse transcriptase-polymerase chain reactionReverse transcriptase-polymerase chain reactionTranscriptase-polymerase chain reactionGene expression signaturesIndependent predictorsPatient survivalPrognostic valuePromising diagnostic toolPolymerase chain reactionHigh riskPredictive valueMicroarray gene expression profilingImportant mediatorPatientsGene expression profiling
2001
Predictive value of expression of transforming growth factor‐β1 and its receptors in transitional cell carcinoma of the urinary bladder
Kim J, Shariat S, Kim I, Menesses‐Diaz A, Tokunaga H, Wheeler T, Lerner S. Predictive value of expression of transforming growth factor‐β1 and its receptors in transitional cell carcinoma of the urinary bladder. Cancer 2001, 92: 1475-1483. PMID: 11745225, DOI: 10.1002/1097-0142(20010915)92:6<1475::aid-cncr1472>3.0.co;2-x.Peer-Reviewed Original ResearchConceptsTransitional cell carcinomaBladder transitional cell carcinomaInvasive tumor stageOverexpression of TGFDisease progressionIndependent predictorsCell carcinomaTumor stageLoss of expressionTGF betaGrowth factorDisease-specific survivalAltered expressionExpression of TGFGrowth factor-β1Lymphovascular invasionRadical cystectomySpecific survivalClinical outcomesCystectomy specimensUrinary bladderImmunohistochemical stainingBlinded fashionFactor-β1Predictive value