Personalized Medicine Approaches in Prostate Cancer Employing Patient Derived 3D Organoids and Humanized Mice
Bartucci M, Ferrari A, Kim I, Ploss A, Yarmush M, Sabaawy H. Personalized Medicine Approaches in Prostate Cancer Employing Patient Derived 3D Organoids and Humanized Mice. Frontiers In Cell And Developmental Biology 2016, 4: 64. PMID: 27446916, PMCID: PMC4917534, DOI: 10.3389/fcell.2016.00064.Peer-Reviewed Original ResearchProstate cancerTumor initiating cellsHuman immune systemHumanized miceTherapeutic responsePersonalized therapeutic responseAdaptive T cellsPrimary prostate cancerPatient-derived organoidsPersonalized medicine approachPCa microenvironmentSelective engraftmentImmunotherapy approachesCommon malignancyCancer deathSpecific therapyImmune cellsDisease progressionCancer precision medicineCommon causeT cellsChimeric antigenPatient-specific therapiesMouse modelTherapy resistance