2020
Distinct vasculotropic versus osteotropic features of S. agalactiae versus S. aureus implant‐associated bone infection in mice
Masters EA, Hao SP, Kenney HM, Morita Y, Galloway CA, de Mesy Bentley K, Ricciardi BF, Boyce BF, Schwarz EM, Oh I. Distinct vasculotropic versus osteotropic features of S. agalactiae versus S. aureus implant‐associated bone infection in mice. Journal Of Orthopaedic Research® 2020, 39: 389-401. PMID: 33336806, PMCID: PMC7882123, DOI: 10.1002/jor.24962.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBone and BonesHost-Pathogen InteractionsMiceOsteomyelitisProsthesis-Related InfectionsStaphylococcal InfectionsStaphylococcus aureusStreptococcal InfectionsStreptococcus agalactiaeConceptsS. aureus osteomyelitisBone infectionS. agalactiaeAnimal modelsS. aureus bone infectionImplant looseningSoft tissueImplant-associated osteomyelitisQuantitative animal modelCortical boneAdjacent soft tissuesGroup B streptococciS. aureusSeptic implant looseningS. agalactiae infectionAssessment of miceS. aureus virulenceGreater body weightDevastating complicationClinical featuresAbscess formationLocal inflammationAggressive osteolysisLess osteolysisPreclinical modelsAdjuvant antibiotic‐loaded bone cement: Concerns with current use and research to make it work
Schwarz EM, McLaren AC, Sculco TP, Brause B, Bostrom M, Kates SL, Parvizi J, Alt V, Arnold WV, Carli A, Chen AF, Choe H, Coraça‐Huber D, Cross M, Ghert M, Hickok N, Jennings JA, Joshi M, Metsemakers W, Ninomiya M, Nishitani K, Oh I, Padgett D, Ricciardi B, Saeed K, Sendi P, Springer B, Stoodley P, Wenke JC, Workgroup H. Adjuvant antibiotic‐loaded bone cement: Concerns with current use and research to make it work. Journal Of Orthopaedic Research® 2020, 39: 227-239. PMID: 31997412, PMCID: PMC7390691, DOI: 10.1002/jor.24616.Peer-Reviewed Original ResearchMeSH KeywordsAnti-Bacterial AgentsBiofilmsBone CementsDrug Resistance, BacterialEvidence-Based MedicineHumansProsthesis-Related InfectionsConceptsAntibiotic-loaded bone cementMusculoskeletal infectionsLevel 1 evidenceRoutine laboratory testingMinimum biofilm eradication concentrationBone cementBiofilm eradication concentrationALBC useBiofilm-associated bacteriaOrthopedic infectionsClinical relevanceClinical practiceDrug AdministrationDrug susceptibilityLocal deliveryEradication concentrationInfectionAntibiotic resistanceCurrent useEfficacyVivo biofilmsLaboratory testingMicrobial colonizationPropose areasSubstantial lack
2019
What Is the Diagnostic “Algorithm” for Infected Total Ankle Arthroplasty (TAA)?
Heidari N, Oh I, Malagelada F. What Is the Diagnostic “Algorithm” for Infected Total Ankle Arthroplasty (TAA)? Foot & Ankle International 2019, 40: 21s-22s. PMID: 31322963, DOI: 10.1177/1071100719859536.Peer-Reviewed Original ResearchMeSH KeywordsAlgorithmsArthroplasty, Replacement, AnkleConsensusDiagnosis, DifferentialHumansProsthesis-Related InfectionsConceptsTotal ankle arthroplastySinus tractJoint aspirationInfected Total Ankle ArthroplastyElevated inflammatory markersSynovial fluid analysisAnkle infectionInflammatory markersOperative interventionArthroplasty infectionClinical symptomsAnkle arthroplastyHistologic examinationSubtalar jointRepeat aspirationSynovial fluidCell countFluid analysisPatientsInfectionNuclear imagingFurther investigationTractAspirationArthroplasty