Evolving concepts in bone infection: redefining “biofilm”, “acute vs. chronic osteomyelitis”, “the immune proteome” and “local antibiotic therapy”
Masters EA, Trombetta RP, de Mesy Bentley KL, Boyce BF, Gill AL, Gill SR, Nishitani K, Ishikawa M, Morita Y, Ito H, Bello-Irizarry SN, Ninomiya M, Brodell JD, Lee CC, Hao SP, Oh I, Xie C, Awad HA, Daiss JL, Owen JR, Kates SL, Schwarz EM, Muthukrishnan G. Evolving concepts in bone infection: redefining “biofilm”, “acute vs. chronic osteomyelitis”, “the immune proteome” and “local antibiotic therapy”. Bone Research 2019, 7: 20. PMID: 31646012, PMCID: PMC6804538, DOI: 10.1038/s41413-019-0061-z.Peer-Reviewed Original ResearchImmune proteomeChronic osteomyelitisBone infectionChronic osteomyelitis casesStaphylococcal abscess communitiesElective orthopaedic surgeryRate of reinfectionHigh patient morbidityLocal antibiotic therapyLocal soft tissueFrequency of infectionDevastating diseaseOsteomyelitis casesAntibiotic therapyCurative treatmentTreatment algorithmOsteomyelitis diagnosisPatient morbiditySerum antibodiesNovel therapiesOsteocyte lacuno-canalicular networkClinical studiesClinical classificationImplant hardwareOsteomyelitis