2023
Suicidal Thoughts and Behaviors in Older U.S. Military Veterans: Results From the National Health and Resilience in Veterans Study
Fischer I, Nichter B, Aunon F, Feldman D, Levy B, Esterlis I, Pietrzak R. Suicidal Thoughts and Behaviors in Older U.S. Military Veterans: Results From the National Health and Resilience in Veterans Study. American Journal Of Geriatric Psychiatry 2023, 31: 844-852. PMID: 37211498, PMCID: PMC10731861, DOI: 10.1016/j.jagp.2023.04.013.Peer-Reviewed Original ResearchMeSH KeywordsAgedDepressive Disorder, MajorHumansResilience, PsychologicalRisk FactorsSuicidal IdeationSuicide, AttemptedUnited StatesVeteransConceptsPast-year suicidal ideationUS military veteransSuicidal ideationLifetime suicide plansSuicide planNational HealthMilitary veteransSuicide intentVeterans StudySuicide attemptsSuicidal thoughtsRepresentative prevalence estimatesMajor depressive disorderLifetime suicide attemptsU.S. military veteransOlder military veteransDepressive disorderPrevalence estimatesLifetime historyProtective factorsSuicide riskPhysical healthLifetime suicideVeteransSelf-report measures
2022
Differences in Quantification of the Metabotropic Glutamate Receptor 5 Across Bipolar Disorder and Major Depressive Disorder
Holmes S, Asch R, Davis M, DellaGioia N, Pashankar N, Gallezot J, Nabulsi N, Matuskey D, Sanacora G, Carson R, Blumberg H, Esterlis I. Differences in Quantification of the Metabotropic Glutamate Receptor 5 Across Bipolar Disorder and Major Depressive Disorder. Biological Psychiatry 2022, 93: 1099-1107. PMID: 36764853, PMCID: PMC10164841, DOI: 10.1016/j.biopsych.2022.10.018.Peer-Reviewed Original ResearchMeSH KeywordsBipolar DisorderDepressive Disorder, MajorHumansMagnetic Resonance ImagingPositron-Emission TomographyPrefrontal CortexReceptor, Metabotropic Glutamate 5ConceptsMajor depressive disorderMetabotropic glutamate receptor 5Glutamate receptor 5MGluR5 availabilityBipolar disorderPositron emission tomographyHC groupDepressive disorderReceptor 5Emission tomographyHealthy control individualsPossible treatment targetsGlutamate transmissionBD depressionTreatment strategiesBD groupMGluR5Depressive symptomsNovel treatmentsCognitive alterationsTreatment targetsSynaptic plasticityControl individualsAccurate diagnosisSignificant negative correlationImaging synaptic density in depression
Holmes SE, Abdallah C, Esterlis I. Imaging synaptic density in depression. Neuropsychopharmacology 2022, 48: 186-190. PMID: 35768568, PMCID: PMC9700860, DOI: 10.1038/s41386-022-01368-4.Peer-Reviewed Original ResearchMeSH KeywordsDepressionDepressive Disorder, MajorHumansKetamineNeuroimagingPositron-Emission TomographyConceptsMagnetic resonance imagingPositron emission tomographySynaptic restorationSynaptic densityAdministration of ketamineMajor depressive disorderUnderstanding of depressionSynaptic alterationsSynaptic involvementDepressive disorderMonoamine systemsPreclinical workTreatment resistanceEffective treatmentDendritic spinesResonance imagingEmission tomographyHeterogeneous disorderDepressionDisordersMore researchInitial studyGliaKetamineBoutonsImaging the effect of ketamine on synaptic density (SV2A) in the living brain
Holmes SE, Finnema SJ, Naganawa M, DellaGioia N, Holden D, Fowles K, Davis M, Ropchan J, Emory P, Ye Y, Nabulsi N, Matuskey D, Angarita GA, Pietrzak RH, Duman RS, Sanacora G, Krystal JH, Carson RE, Esterlis I. Imaging the effect of ketamine on synaptic density (SV2A) in the living brain. Molecular Psychiatry 2022, 27: 2273-2281. PMID: 35165397, PMCID: PMC9133063, DOI: 10.1038/s41380-022-01465-2.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntidepressive AgentsBrainDepressive Disorder, MajorHumansKetamineMacaca mulattaMembrane GlycoproteinsNerve Tissue ProteinsPositron-Emission TomographyConceptsKetamine's therapeutic effectsMajor depressive disorderTherapeutic effectPositron emission tomographyPosttraumatic stress disorderHealthy controlsSynaptic connectionsSynaptic vesicle protein 2APost-synaptic mechanismsEffects of ketamineDiscovery of ketamineNon-human primatesAntidepressant effectsDepressive disorderSingle administrationSynaptic densityPsychiatric disordersDepression severityKetamineEmission tomographyTerminal densityLiving brainStress disorderRobust reductionDissociative symptoms
2021
Macro- and Microscale Stress–Associated Alterations in Brain Structure: Translational Link With Depression
Banasr M, Sanacora G, Esterlis I. Macro- and Microscale Stress–Associated Alterations in Brain Structure: Translational Link With Depression. Biological Psychiatry 2021, 90: 118-127. PMID: 34001371, DOI: 10.1016/j.biopsych.2021.04.004.Peer-Reviewed Original ResearchConceptsMajor depressive disorderStress-related disordersCytoarchitectural alterationsPathophysiology of MDDChronic stress pathologyDepressive-like behaviorChronic stress modelAnimal stress modelsPositron emission tomographyHuman brain tissueAstroglial alterationsSynaptic deficitsNeurochemical changesDepressive disorderBehavioral deficitsRodent modelsBrain tissueEmission tomographyDepression symptomatologyLiving brainBrain structuresNovel drugsTranslational linkStress pathologyDisordersAcute cognitive effects of single-dose intravenous ketamine in major depressive and posttraumatic stress disorder
Davis MT, DellaGiogia N, Maruff P, Pietrzak RH, Esterlis I. Acute cognitive effects of single-dose intravenous ketamine in major depressive and posttraumatic stress disorder. Translational Psychiatry 2021, 11: 205. PMID: 33833217, PMCID: PMC8032778, DOI: 10.1038/s41398-021-01327-5.Peer-Reviewed Original ResearchMeSH KeywordsAntidepressive AgentsCognitionDepressive Disorder, MajorHumansKetamineStress Disorders, Post-TraumaticConceptsPosttraumatic stress disorderExecutive functionStress disorderCognitive functionSingle-dose intravenous ketamineAcute cognitive effectsLarge magnitude improvementsPTSD relativeCognitive measuresCognitive domainsPTSD individualsMemory performanceCognitive effectsYears of educationBaseline performanceCognitive declineHealthy controlsPsychiatric distressCognitive dysfunctionHC individualsHC groupDepressive symptomsMemory 2Subanesthetic doseMajor depressive