First in vivo evaluations of synaptic density alterations in the brain
Esterlis I, Holmes S. First in vivo evaluations of synaptic density alterations in the brain. Neuropsychopharmacology 2021, 47: 381-382. PMID: 34285369, PMCID: PMC8617161, DOI: 10.1038/s41386-021-01099-y.Peer-Reviewed Original ResearchBrainSynapsesIdentifying brain networks in synaptic density PET (11C-UCB-J) with independent component analysis
Fang XT, Toyonaga T, Hillmer AT, Matuskey D, Holmes SE, Radhakrishnan R, Mecca AP, van Dyck CH, D’Souza D, Esterlis I, Worhunsky PD, Carson RE. Identifying brain networks in synaptic density PET (11C-UCB-J) with independent component analysis. NeuroImage 2021, 237: 118167. PMID: 34000404, PMCID: PMC8452380, DOI: 10.1016/j.neuroimage.2021.118167.Peer-Reviewed Original ResearchConceptsSynaptic densityResting-state functional magnetic resonance imagingSynaptic vesicle protein 2ALevel-dependent signal fluctuationsBrain networksFunctional magnetic resonance imagingMagnetic resonance imagingAge-related changesHealthy controlsResonance imagingRs-fMRIEffects of sexProtein 2AMultiple comparisonsHuman brainAgePotential utilitySexFirst evidenceCovariance patternsMacro- and Microscale Stress–Associated Alterations in Brain Structure: Translational Link With Depression
Banasr M, Sanacora G, Esterlis I. Macro- and Microscale Stress–Associated Alterations in Brain Structure: Translational Link With Depression. Biological Psychiatry 2021, 90: 118-127. PMID: 34001371, DOI: 10.1016/j.biopsych.2021.04.004.Peer-Reviewed Original ResearchConceptsMajor depressive disorderStress-related disordersCytoarchitectural alterationsPathophysiology of MDDChronic stress pathologyDepressive-like behaviorChronic stress modelAnimal stress modelsPositron emission tomographyHuman brain tissueAstroglial alterationsSynaptic deficitsNeurochemical changesDepressive disorderBehavioral deficitsRodent modelsBrain tissueEmission tomographyDepression symptomatologyLiving brainBrain structuresNovel drugsTranslational linkStress pathologyDisorders