2024
Challenges and rewards of in vivo synaptic density imaging, and its application to the study of depression
Asch R, Abdallah C, Carson R, Esterlis I. Challenges and rewards of in vivo synaptic density imaging, and its application to the study of depression. Neuropsychopharmacology 2024, 50: 153-163. PMID: 39039139, PMCID: PMC11525584, DOI: 10.1038/s41386-024-01913-3.Peer-Reviewed Original ResearchStudies of depressionAnimal models of chronic stressPositron emission tomographyModel of chronic stressSV2A imagingSynaptic densitySignificant depressive symptomsDevelopment of novel radiotracersDepressive symptomsNeuropsychiatric disordersSymptom severityChronic stressDrug challengeSynaptic vesicle glycoprotein 2 ANeural markersAnimal modelsSynaptic alterationsSynaptogenesis in vivoPreliminary findingsIn vivo quantificationCentral nervous systemDepressionEmission tomographySV2ASV2A positron emission tomography
2022
Imaging synaptic density in depression
Holmes SE, Abdallah C, Esterlis I. Imaging synaptic density in depression. Neuropsychopharmacology 2022, 48: 186-190. PMID: 35768568, PMCID: PMC9700860, DOI: 10.1038/s41386-022-01368-4.Peer-Reviewed Original ResearchConceptsMagnetic resonance imagingPositron emission tomographySynaptic restorationSynaptic densityAdministration of ketamineMajor depressive disorderUnderstanding of depressionSynaptic alterationsSynaptic involvementDepressive disorderMonoamine systemsPreclinical workTreatment resistanceEffective treatmentDendritic spinesResonance imagingEmission tomographyHeterogeneous disorderDepressionDisordersMore researchInitial studyGliaKetamineBoutons