2013
Therapeutic Potential of Human Induced Pluripotent Stem Cells in Experimental Stroke
Chang DJ, Lee N, Park IH, Choi C, Jeon I, Kwon J, Oh SH, Shin DA, Tae J, Lee DR, Lee H, Hong K, Daley G, Song J, Moon H. Therapeutic Potential of Human Induced Pluripotent Stem Cells in Experimental Stroke. Cell Transplantation 2013, 22: 1427-1440. PMID: 23044029, DOI: 10.3727/096368912x657314.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApoptosisBehavior, AnimalCell DifferentiationCell LineCell TrackingDisease Models, AnimalGliosisHumansInduced Pluripotent Stem CellsInfarction, Middle Cerebral ArteryInflammationMagnetic Resonance ImagingMaleMiceNeural Stem CellsNeurogenesisNeuronsRatsRats, Sprague-DawleyStem Cell TransplantationStrokeConceptsMiddle cerebral artery occlusionNeural precursor cellsNeural stem cellsStroke-induced inflammatory responseTherapeutic potentialMCAO stroke modelCerebral artery occlusionPeri-infarct areaTreatment of strokeLimited therapeutic optionsStem cellsAutologous cell therapyEndogenous neurogenesisExperimental strokePluripotent stem cellsArtery occlusionIschemic strokeBehavioral recoveryTherapeutic optionsNeurological functionInflammatory responseRobust therapeutic potentialStroke modelMRI resultsAnimal models
2012
Neuronal Properties, In Vivo Effects, and Pathology of a Huntington's Disease Patient‐Derived Induced Pluripotent Stem Cells
Jeon I, Lee N, Li J, Park I, Park KS, Moon J, Shim SH, Choi C, Chang D, Kwon J, Oh S, Shin DA, Kim HS, Tae J, Lee DR, Kim M, Kang K, Daley GQ, Brundin P, Song J. Neuronal Properties, In Vivo Effects, and Pathology of a Huntington's Disease Patient‐Derived Induced Pluripotent Stem Cells. Stem Cells 2012, 30: 2054-2062. PMID: 22628015, DOI: 10.1002/stem.1135.Peer-Reviewed Original ResearchConceptsHD-iPSCHD pathologyHuntington's diseaseDisease patientsNeuronal propertiesUnilateral excitotoxic striatal lesionExcitotoxic striatal lesionsSignificant behavioral recoveryStem cellsGABAergic striatal neuronsHuntington's disease patientsCAG repeatsNeuronal cell typesPluripotent stem cellsBehavioral recoveryGABAergic neuronsStriatal lesionsStriatal neuronsRat modelNeonatal brainNovel cell therapiesVivo effectsHD phenotypeCell therapyNovel therapeutics
2011
Induced pluripotent stem cells for neural tissue engineering
Wang A, Tang Z, Park IH, Zhu Y, Patel S, Daley GQ, Li S. Induced pluripotent stem cells for neural tissue engineering. Biomaterials 2011, 32: 5023-5032. PMID: 21514663, PMCID: PMC3100451, DOI: 10.1016/j.biomaterials.2011.03.070.Peer-Reviewed Original ResearchConceptsEmbryonic stem cellsTissue engineeringNeural tissue engineeringPluripotent stem cellsNanofibrous tubular scaffoldsRegenerative medicine applicationsStem cellsTissue-engineered nerve conduitNeural crest stem cellsDifferentiation of iPSCsTeratoma formationMedicine applicationsGreat promiseTremendous potentialIPSC differentiationEctodermal lineagesTubular scaffoldsMultipotent neural crest stem cellsCell therapyEngineeringHuman iPSCDifferent cell linesAccelerated regenerationScaffoldsIPSCs