2016
Neural Stem Cells Restore Hair Growth through Activation of the Hair Follicle Niche
Hwang I, Choi KA, Park HS, Jeong H, Kim JO, Seol KC, Kwon HJ, Park IH, Hong S. Neural Stem Cells Restore Hair Growth through Activation of the Hair Follicle Niche. Cell Transplantation 2016, 25: 1439-1451. PMID: 27110030, DOI: 10.3727/096368916x691466.Peer-Reviewed Original ResearchConceptsInsulin-like growth factor-1Shaven dorsal skinNeural stem cellsVascular endothelial growth factorDermal papilla cellsHepatocyte growth factorKeratinocyte growth factorGrowth factorHair follicle nicheHair growthDorsal skinStem cellsAnagen phaseGrowth factor-1Endothelial growth factorGrowth factor pathwaysCombined growth factorsMolecular signaling pathwaysPharmacological therapyHair regrowthHair shaft lengthBone morphogenetic protein family membersNSC treatmentProtein family membersHair follicle stem cells
2010
Directed differentiation of hematopoietic precursors and functional osteoclasts from human ES and iPS cells
Grigoriadis AE, Kennedy M, Bozec A, Brunton F, Stenbeck G, Park IH, Wagner EF, Keller GM. Directed differentiation of hematopoietic precursors and functional osteoclasts from human ES and iPS cells. Blood 2010, 115: 2769-2776. PMID: 20065292, PMCID: PMC2854424, DOI: 10.1182/blood-2009-07-234690.Peer-Reviewed Original ResearchConceptsPluripotent stem cellsInduced pluripotent stem cellsStem cellsPrimitive streak-like populationHuman pluripotent stem cellsHuman cell typesEmbryonic bone developmentEmbryoid bodiesBone-resorbing osteoclastsMacrophage colony-stimulating factorIPS cellsHematopoietic cytokinesCell typesMolecular analysisCathepsin KHuman ESHematopoietic precursorsPrecursor populationAlphavbeta3 integrinBone developmentConfocal microscopyAbsence of RANKLNuclear factor-kappaB ligandDisease mechanismsSerum-free medium