2019
The critical role of persistent sodium current in hippocampal gamma oscillations
Kang YJ, Clement EM, Sumsky SL, Xiang Y, Park IH, Santaniello S, Greenfield LJ, Garcia-Rill E, Smith BN, Lee SH. The critical role of persistent sodium current in hippocampal gamma oscillations. Neuropharmacology 2019, 162: 107787. PMID: 31550457, PMCID: PMC6952064, DOI: 10.1016/j.neuropharm.2019.107787.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCA1 Region, HippocampalCalcium-Calmodulin-Dependent Protein Kinase Type 2Excitatory Amino Acid AntagonistsExcitatory Postsynaptic PotentialsGABAergic NeuronsGamma RhythmHippocampusInhibitory Postsynaptic PotentialsInterneuronsMiceOptogeneticsParvalbuminsPatch-Clamp TechniquesPhenytoinPyramidal CellsRiluzoleSodiumVoltage-Gated Sodium Channel BlockersConceptsParvalbumin-expressing basket cellsHippocampal gamma oscillationsCortical gamma oscillationsGABAergic interneuronsGamma oscillationsPyramidal cellsNon-inactivating sodium currentExcitatory cellsSodium currentWhole-cell patch-clamp recordingsNetwork oscillationsPatch-clamp recordingsPersistent sodium currentGamma network oscillationsAnticonvulsant efficacyGamma frequency rangeEpilepsy patientsBasket cellsCognitive impairmentAction potentialsSynaptic propertiesSynaptic interactionsOptogenetic stimulationElectrophysiological approachesCA1 network
2011
Induced pluripotent stem cell models from X‐linked adrenoleukodystrophy patients
Jang J, Kang H, Kim H, Kim JY, Huh YJ, Kim D, Yoo J, Lee J, Lim B, Lee J, Yoon T, Park I, Hwang D, Daley GQ, Kim D. Induced pluripotent stem cell models from X‐linked adrenoleukodystrophy patients. Annals Of Neurology 2011, 70: 402-409. PMID: 21721033, DOI: 10.1002/ana.22486.Peer-Reviewed Original ResearchMeSH KeywordsAdrenoleukodystrophyATP Binding Cassette Transporter, Subfamily DATP-Binding Cassette TransportersBrainCell DifferentiationDNAExcitatory Postsynaptic PotentialsFatty Acids, NonesterifiedHematopoietic Stem Cell TransplantationHumansHydroxymethylglutaryl-CoA Reductase InhibitorsInduced Pluripotent Stem CellsLovastatinNeuronsOligodendrogliaPhenotypePhenylbutyratesReverse Transcriptase Polymerase Chain ReactionConceptsChildhood cerebral ALDX-ALDVLCFA accumulationLong chain fatty acid levelsAppropriate animal model systemsSevere clinical manifestationsFatty acid levelsAnimal model systemsDisease-relevant phenotypesClinical manifestationsCerebral ALDABCD1 mutationsAdrenoleukodystrophy patientsDevelopment of therapeuticsHuman oligodendrocytesUnique cellular modelDisease subtypesAbnormal accumulationAccurate diagnosisPluripotent stem cell modelsOligodendrocytesNew therapeuticsAcid levelsOligodendrocyte differentiationStem cell model