2012
Overcoming reprogramming resistance of Fanconi anemia cells
Müller LU, Milsom MD, Harris CE, Vyas R, Brumme KM, Parmar K, Moreau LA, Schambach A, Park IH, London WB, Strait K, Schlaeger T, DeVine AL, Grassman E, D'Andrea A, Daley GQ, Williams DA. Overcoming reprogramming resistance of Fanconi anemia cells. Blood 2012, 119: 5449-5457. PMID: 22371882, PMCID: PMC3369681, DOI: 10.1182/blood-2012-02-408674.Peer-Reviewed Original ResearchConceptsFA cellsFA pathwayFA DNA repair pathwayFanconi anemiaDNA double-strand breaksFanconi anemia cellsStem cellsDNA repair pathwaysDouble-strand breaksDisease-specific iPSCsPluripotent stem cellsFuture translational applicationsGenomic integrityHuman primary cellsHematopoietic stem cellsHematopoietic differentiationChromosomal instabilityMolecular characterizationGene correctionTransgenic expressionDNA damageGenetic correctionHematopoietic cellsPrimary cellsPathway
2009
Down's syndrome suppression of tumour growth and the role of the calcineurin inhibitor DSCR1
Baek KH, Zaslavsky A, Lynch RC, Britt C, Okada Y, Siarey RJ, Lensch MW, Park IH, Yoon SS, Minami T, Korenberg JR, Folkman J, Daley GQ, Aird WC, Galdzicki Z, Ryeom S. Down's syndrome suppression of tumour growth and the role of the calcineurin inhibitor DSCR1. Nature 2009, 459: 1126-1130. PMID: 19458618, PMCID: PMC2724004, DOI: 10.1038/nature08062.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCalcineurinCalcium-Binding ProteinsCatecholsCells, CulturedDisease Models, AnimalDNA-Binding ProteinsDown SyndromeEndothelial CellsGene DosageHumansInositolIntracellular Signaling Peptides and ProteinsMiceMice, TransgenicMuscle ProteinsProtein Serine-Threonine KinasesProtein-Tyrosine Kinases