2011
Evi-1 Regulates Myelopoiesis and Hematopoietic Stem Cell Development in Zebrafish and Human Pluripotent Stem Cells
Konantz M, Grauer M, Grzywna S, Brugman M, Kanz L, Park I, Daley G, Baum C, Lengerke C. Evi-1 Regulates Myelopoiesis and Hematopoietic Stem Cell Development in Zebrafish and Human Pluripotent Stem Cells. Blood 2011, 118: 1281. DOI: 10.1182/blood.v118.21.1281.1281.Peer-Reviewed Original ResearchHuman pluripotent stem cellsPluripotent stem cellsEvi-1Developmental hematopoiesisZebrafish embryosHematopoietic developmentHematopoietic stem cellsStem cellsPosterior lateral plate mesodermHematopoietic stem cell developmentPosterior blood islandHuman developmental hematopoiesisLateral plate mesodermStem cell developmentPre-mRNA splicingEvi-1 locusDays post fertilizationHematopoietic stem cell proliferationMurine hematopoietic cellsStem cell proliferationExpression of PUEmbryonic myelopoiesisEvi-1 expressionErythroid progenitor cellsPrimitive erythroid progenitor cells
2009
The Zebrafish Homologue of the Murine Ecotropic Viral Integration Site-1 (. Evi-1) gene Regulates Zebrafish Embryonic Blood Development.
Konantz M, Brugman M, Park I, Daley G, Nuesslein-Volhard C, Baum C, Lengerke C. The Zebrafish Homologue of the Murine Ecotropic Viral Integration Site-1 (. Evi-1) gene Regulates Zebrafish Embryonic Blood Development. Blood 2009, 114: 1461. DOI: 10.1182/blood.v114.22.1461.1461.Peer-Reviewed Original ResearchZebrafish embryonic developmentBlood developmentEvi-1Embryonic hematopoiesisEmbryonic developmentPluripotent stem cellsGATA1 expressionHematopoietic developmentPosterior lateral plate mesodermPosterior blood islandWild-type embryosMorpholino-injected embryosLateral plate mesodermPre-mRNA splicingStem cellsSomite stage embryosAdult hematopoietic cellsHuman pluripotent stem cellsReal-time PCR analysisHematopoietic stem cell proliferationHuman blood developmentStem cell proliferationHuman iPS cellsZebrafish homologueErythroid progenitor cellsHematopoietic Development From Human Induced Pluripotent Stem Cells.
Grauer M, Konantz M, Niebuhr N, Kanz L, Park I, Daley G, Lengerke C. Hematopoietic Development From Human Induced Pluripotent Stem Cells. Blood 2009, 114: 2530. DOI: 10.1182/blood.v114.22.2530.2530.Peer-Reviewed Original ResearchMouse embryonic stem cellsEmbryonic stem cellsInduced pluripotent stem cellsPluripotent stem cellsHuman embryonic stem cellsHematopoietic stem cellsHuman induced pluripotent stem cellsHuman iPS cellsIPS cellsCdx genesHematopoietic developmentBlood lineagesStem cellsBlood formationEmbryonic blood formationGenetic modificationHuman developmental hematopoiesisDifferentiated somatic cellsHuman pluripotent stem cell linesStem cell linesIrradiated adult micePluripotent stem cell lineDevelopmental hematopoiesisHematopoietic genesHox genesHematopoietic Development from Human Induced Pluripotent Stem Cells
Lengerke C, Grauer M, Niebuhr NI, Riedt T, Kanz L, Park I, Daley GQ. Hematopoietic Development from Human Induced Pluripotent Stem Cells. Annals Of The New York Academy Of Sciences 2009, 1176: 219-227. PMID: 19796250, PMCID: PMC2849804, DOI: 10.1111/j.1749-6632.2009.04606.x.Peer-Reviewed Original ResearchConceptsEmbryonic stem cellsMouse embryonic stem cellsPluripotent stem cellsHematopoietic developmentInduced pluripotent stem cellsHuman induced pluripotent stem cellsHematopoietic stem cellsStem cellsDifferentiated somatic cellsHuman embryonic stem cellsHuman hematopoietic developmentStem cell linesGene expression dataIrradiated adult miceHox genesPluripotent stateBlood lineagesSomatic cellsEctopic expressionCombinatorial overexpressionExpression dataBlood formationIPS cellsColony activityMultilineage reconstitution