2020
Intracerebral Transplants of GMP-Grade Human Umbilical Cord-Derived Mesenchymal Stromal Cells Effectively Treat Subacute-Phase Ischemic Stroke in a Rodent Model
Noh JE, Oh SH, Park IH, Song J. Intracerebral Transplants of GMP-Grade Human Umbilical Cord-Derived Mesenchymal Stromal Cells Effectively Treat Subacute-Phase Ischemic Stroke in a Rodent Model. Frontiers In Cellular Neuroscience 2020, 14: 546659. PMID: 33100972, PMCID: PMC7546889, DOI: 10.3389/fncel.2020.546659.Peer-Reviewed Original ResearchHuman umbilical cord-derived mesenchymal stromal cellsMiddle cerebral artery occlusionMesenchymal stromal cellsSubacute phaseRodent modelsUmbilical cord-derived mesenchymal stromal cellsStromal cellsIschemic penumbra regionCerebral artery occlusionGlial scar formationDelivery modeSame time pointsHuman umbilical cordStem cell therapyCandidate cell typesInfarct volumeArtery occlusionIschemic strokeIntracerebral transplantsTransplanted ratsCell-based therapiesChronic phaseFunctional recoveryTherapeutic effectBehavioral deficits
2013
Therapeutic Potential of Human Induced Pluripotent Stem Cells in Experimental Stroke
Chang DJ, Lee N, Park IH, Choi C, Jeon I, Kwon J, Oh SH, Shin DA, Tae J, Lee DR, Lee H, Hong K, Daley G, Song J, Moon H. Therapeutic Potential of Human Induced Pluripotent Stem Cells in Experimental Stroke. Cell Transplantation 2013, 22: 1427-1440. PMID: 23044029, DOI: 10.3727/096368912x657314.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApoptosisBehavior, AnimalCell DifferentiationCell LineCell TrackingDisease Models, AnimalGliosisHumansInduced Pluripotent Stem CellsInfarction, Middle Cerebral ArteryInflammationMagnetic Resonance ImagingMaleMiceNeural Stem CellsNeurogenesisNeuronsRatsRats, Sprague-DawleyStem Cell TransplantationStrokeConceptsMiddle cerebral artery occlusionNeural precursor cellsNeural stem cellsStroke-induced inflammatory responseTherapeutic potentialMCAO stroke modelCerebral artery occlusionPeri-infarct areaTreatment of strokeLimited therapeutic optionsStem cellsAutologous cell therapyEndogenous neurogenesisExperimental strokePluripotent stem cellsArtery occlusionIschemic strokeBehavioral recoveryTherapeutic optionsNeurological functionInflammatory responseRobust therapeutic potentialStroke modelMRI resultsAnimal models