Human Pluripotent Stem Cells Produce Natural Killer Cells That Mediate Anti-HIV-1 Activity by Utilizing Diverse Cellular Mechanisms
Ni Z, Knorr DA, Clouser CL, Hexum MK, Southern P, Mansky LM, Park IH, Kaufman DS. Human Pluripotent Stem Cells Produce Natural Killer Cells That Mediate Anti-HIV-1 Activity by Utilizing Diverse Cellular Mechanisms. Journal Of Virology 2010, 85: 43-50. PMID: 20962093, PMCID: PMC3014194, DOI: 10.1128/jvi.01774-10.Peer-Reviewed Original ResearchConceptsNK cellsHIV/AIDSAnti-HIV-1 immunityHIV-1-infected individualsAntibody-dependent cellular cytotoxicityTumor cellsCEM-GFP cellsFunctional NK cellsAnti-HIV-1 activityNatural killer cellsHIV-1 infectionProduction of chemokinesCellular mechanismsHIV-1 replicationStem cellsCellular immunotherapeutic approachesInnate immune systemVirus-infected cellsInfected targetsPluripotent stem cellsImmunotherapeutic approachesNatural killerKiller cellsCell-based therapiesT cells