2021
Sex-Related Differences in Dynamic Right Ventricular-Pulmonary Vascular Coupling in Heart Failure With Preserved Ejection Fraction
Singh I, Oliveira RKF, Heerdt PM, Pari R, Systrom DM, Waxman AB. Sex-Related Differences in Dynamic Right Ventricular-Pulmonary Vascular Coupling in Heart Failure With Preserved Ejection Fraction. CHEST Journal 2021, 159: 2402-2416. PMID: 33388286, DOI: 10.1016/j.chest.2020.12.028.Peer-Reviewed Original ResearchMeSH KeywordsAgedCardiac CatheterizationEchocardiographyExercise ToleranceFemaleFollow-Up StudiesHeart FailureHeart VentriclesHumansIncidenceMalePulmonary ArteryPulmonary Wedge PressureRetrospective StudiesSex DistributionSex FactorsStroke VolumeSystoleUnited StatesVascular ResistanceVentricular Function, RightVentricular PressureConceptsRV-PA couplingRV-PA uncouplingFemale patientsMale patientsPeak VORV contractilityEjection fractionHeart failureRight ventricular-pulmonary vascular couplingRV-pulmonary arterial couplingAge-matched control subjectsInvasive pulmonary hemodynamicsMaximum incremental exercisePulmonary arterial elastanceRV pressure waveformsPeak exercise capacityRight ventricular dysfunctionSingle-beat analysisEnd-systolic elastanceSex-related differencesPA elastanceRV afterloadVentricular dysfunctionAfterload mismatchContractile impairment
2020
Dynamic right ventricular function response to incremental exercise in pulmonary hypertension
Singh I, Oliveira RKF, Heerdt P, Brown MB, Faria‐Urbina M, Waxman AB, Systrom DM. Dynamic right ventricular function response to incremental exercise in pulmonary hypertension. Pulmonary Circulation 2020, 10: 1-8. PMID: 33062259, PMCID: PMC7534091, DOI: 10.1177/2045894020950187.Peer-Reviewed Original ResearchRight ventricle functionRight ventricle stroke work indexStroke work indexPulmonary hypertensionVentricle functionPeak oxygen uptakePeak VOIncremental exerciseArterial elastanceWork indexInvasive cardiopulmonary exercise testingGender-matched normal controlsExercise pulmonary hypertensionMaximum incremental exercisePulmonary arterial elastancePulmonary hypertension groupRight ventricle adaptationVentricular function responseCardiopulmonary exercise testingPulmonary hypertension patientsRight ventricle dysfunctionPulmonary arterial hypertensionOxygen uptakeArterial hypertensionHypertension group
2019
Dynamic right ventricular–pulmonary arterial uncoupling during maximum incremental exercise in exercise pulmonary hypertension and pulmonary arterial hypertension
Singh I, Rahaghi F, Naeije R, Oliveira R, Vanderpool RR, Waxman A, Systrom D. Dynamic right ventricular–pulmonary arterial uncoupling during maximum incremental exercise in exercise pulmonary hypertension and pulmonary arterial hypertension. Pulmonary Circulation 2019, 9: 1-10. PMID: 31218910, PMCID: PMC6643191, DOI: 10.1177/2045894019862435.Peer-Reviewed Original ResearchPulmonary arterial hypertensionExercise pulmonary hypertensionRV-PA couplingMaximum incremental exerciseRV-PA uncouplingPulmonary hypertensionExercise pHRV contractilityArterial hypertensionExercise capacityIncremental exerciseInvasive cardiopulmonary exercise testingReduced peak oxygen consumptionPressure-volume loop analysisPulmonary arterial elastanceCardiopulmonary exercise testingRight ventricular functionPeak oxygen consumptionAge-matched controlsEnd-systolic elastanceContractile reserveExercise testingRV functionSuch patientsVentricular functionRight Ventricular-Arterial Uncoupling During Exercise in Heart Failure With Preserved Ejection Fraction Role of Pulmonary Vascular Dysfunction
Singh I, Rahaghi FN, Naeije R, Oliveira RKF, Systrom DM, Waxman AB. Right Ventricular-Arterial Uncoupling During Exercise in Heart Failure With Preserved Ejection Fraction Role of Pulmonary Vascular Dysfunction. CHEST Journal 2019, 156: 933-943. PMID: 31103695, DOI: 10.1016/j.chest.2019.04.109.Peer-Reviewed Original ResearchConceptsEes/EaRV-PA uncouplingPulmonary vascular dysfunctionResistive afterloadHeart failureVascular dysfunctionRight ventricular-pulmonary artery couplingLower pulmonary artery complianceRight ventricular-arterial uncouplingInvasive pulmonary hemodynamicsPulmonary arterial elastanceRV contractile reserveRV pressure waveformsVentricular-arterial uncouplingRight ventricular dysfunctionExercise-induced decreasePulmonary artery complianceExercise-induced increaseGroup of patientsLower peak VOLower stroke volumePeak oxygen consumptionSingle-beat analysisEnd-systolic elastancePVR response