Oxytocin and Stress-related Disorders: Neurobiological Mechanisms and Treatment Opportunities
Sippel LM, Allington CE, Pietrzak RH, Harpaz-Rotem I, Mayes LC, Olff M. Oxytocin and Stress-related Disorders: Neurobiological Mechanisms and Treatment Opportunities. Chronic Stress 2017, 1: 2470547016687996. PMID: 28649672, PMCID: PMC5482285, DOI: 10.1177/2470547016687996.Peer-Reviewed Original ResearchStress-related disordersStress-related psychiatric disordersNeurobiological mechanismsPosttraumatic stress disorderCritical moderating variablePsychiatric disordersStress disorderNeurohormone oxytocinClinical populationsEndogenous oxytocinModerating variableHeterogeneous findingsHealthy samplesOverview of evidenceSingle-dose studyMajor depressive disorderPromising findingsOxytocinDisordersDepressive disorderDosing schedulesNovel pharmacotherapiesMultidose studyReliable biomarkersTreatment opportunitiesFear extinction and memory reconsolidation as critical components in behavioral treatment for posttraumatic stress disorder and potential augmentation of these processes
Smith NB, Doran JM, Sippel LM, Harpaz-Rotem I. Fear extinction and memory reconsolidation as critical components in behavioral treatment for posttraumatic stress disorder and potential augmentation of these processes. Neuroscience Letters 2017, 649: 170-175. PMID: 28065842, DOI: 10.1016/j.neulet.2017.01.006.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderReconsolidation processPTSD psychotherapyStress disorderBehavioral treatmentExposure-based treatmentsCritical brain regionsFear extinctionMemory reconsolidationTraumatic memoriesImportant future directionsPTSD populationsPTSD therapyNeurobiological mechanismsPrefrontal cortexReconsolidationBrain regionsPsychotherapyProcess of extinctionMemoryPotential avenuesFuture directionsBehavioral modificationExtinctionDisorders