2024
Progesterone Receptor Status predicts Aggressiveness of Human Endometriotic lesions in Murine Avatars
Flores V, Sahin C, Taylor H. Progesterone Receptor Status predicts Aggressiveness of Human Endometriotic lesions in Murine Avatars. F&S Science 2024 PMID: 39393571, DOI: 10.1016/j.xfss.2024.10.004.Peer-Reviewed Original ResearchProgestin-based therapyAggressive forms of endometriosisPR lesionsProgesterone receptorGnRH antagonistMedroxyprogesterone acetatePR statusEndometriotic lesionsAggressive formResponse to MPAResponse to medical therapyPost-treatment sizeProgesterone receptor statusHuman endometriotic lesionsResponse to progestinsChronic gynecological diseaseDaily subcutaneous injectionsReproductive-age womenMouse xenograft modelResponse to medicationEndometrioma lesionsReceptor statusHormone suppressionPR expressionClinical response
2023
Donor Mesenchymal Stem Cells Program Bone Marrow, Altering Macrophages, and Suppressing Endometriosis in Mice
Habata S, Mamillapalli R, Ucar A, Taylor H. Donor Mesenchymal Stem Cells Program Bone Marrow, Altering Macrophages, and Suppressing Endometriosis in Mice. Stem Cells International 2023, 2023: 1598127. PMID: 37545483, PMCID: PMC10403325, DOI: 10.1155/2023/1598127.Peer-Reviewed Original ResearchBone marrowMesenchymal stem cellsBM transplantsEndometriotic lesionsM2 macrophagesBone marrow-derived inflammatory cellsTumor necrosis factor alphaImmune system contributionsDonor mesenchymal stem cellsProportion of M1Infiltration of macrophagesDevelopment of endometriosisNecrosis factor alphaNew therapeutic targetsRecipient bone marrowReal-time polymerase chain reactionQuantitative real-time polymerase chain reactionEndometriotic lesion developmentInflammatory markersEndometrial tissueInflammatory cellsRecipient micePolymerase chain reactionInflammatory responseFluorescence-activated cell sorting