2009
WT1 represses HOX gene expression in the regulation of gynaecologic tumour histologic type
Andikyan V, Taylor HS. WT1 represses HOX gene expression in the regulation of gynaecologic tumour histologic type. Journal Of Cellular And Molecular Medicine 2009, 13: 4522-4531. PMID: 19017365, PMCID: PMC3107857, DOI: 10.1111/j.1582-4934.2008.00574.x.Peer-Reviewed Original ResearchMeSH KeywordsCell Line, TumorEndometrial NeoplasmsEndometriumEnhancer Elements, GeneticFemaleGene Expression ProfilingGene Expression Regulation, NeoplasticGenital Neoplasms, FemaleHomeobox A10 ProteinsHomeodomain ProteinsHumansKidneyMullerian DuctsOvarian NeoplasmsPromoter Regions, GeneticProtein BindingRepressor ProteinsUterine Cervical NeoplasmsWT1 ProteinsConceptsHox gene expressionGene expressionHomeobox gene HOXA10HOXA10 expressionEpithelial cell typesHox genesTumor 1 geneRepressor activityHomeobox genesEpithelial enhancersTranscription factorsEmbryonic developmentRegulatory elementsExpression of WT1Enhancer activitySelective repressionRepressor elementAberrant regulationDevelopmental identityOvarian cancer cellsUterine organogenesisCell typesGenesRepressorCancer cells
2007
Differential Cell-Specific Modulation of HOXA10 by Estrogen and Specificity Protein 1 Response Elements
Martin R, Taylor MB, Krikun G, Lockwood C, Akbas GE, Taylor HS. Differential Cell-Specific Modulation of HOXA10 by Estrogen and Specificity Protein 1 Response Elements. The Journal Of Clinical Endocrinology & Metabolism 2007, 92: 1920-1926. PMID: 17311863, DOI: 10.1210/jc.2006-1694.Peer-Reviewed Original ResearchMeSH KeywordsBreastCells, CulturedElectrophoretic Mobility Shift AssayEstrogensFemaleGenes, ReporterHomeobox A10 ProteinsHomeodomain ProteinsHumansImmunohistochemistryLuciferasesPlasmidsReceptors, EstrogenResponse ElementsReverse Transcriptase Polymerase Chain ReactionSp1 Transcription FactorTransfectionUterusConceptsEstrogen response elementHOXA10 estrogen response elementResponse elementSp1 sitesShift assaysStage-specific expression patternsTissue specificityElectrophoretic mobility shift assaysCell typesSpecificity protein 1Mobility shift assaysAdult reproductive tractGel shift assaysDifferential cellular expressionDistinct differential expressionHox genesSp1 proteinCell-specific modulationTranscription factorsEmbryonic developmentRegulatory elementsExpression patternsReporter assaysBreast MCF-7 cellsDifferential expression