2015
Discovery of Antibiotic (E)‑3-(3-Carboxyphenyl)-2-(4-cyanostyryl)quinazolin-4(3H)‑one
Bouley R, Kumarasiri M, Peng Z, Otero L, Song W, Suckow M, Schroeder V, Wolter W, Lastochkin E, Antunes N, Pi H, Vakulenko S, Hermoso J, Chang M, Mobashery S. Discovery of Antibiotic (E)‑3-(3-Carboxyphenyl)-2-(4-cyanostyryl)quinazolin-4(3H)‑one. Journal Of The American Chemical Society 2015, 137: 1738-1741. PMID: 25629446, PMCID: PMC4607046, DOI: 10.1021/jacs.5b00056.Peer-Reviewed Original Research
2014
Structure and Cell Wall Cleavage by Modular Lytic Transglycosylase MltC of Escherichia coli
Artola-Recolons C, Lee M, Bernardo-García N, Blázquez B, Hesek D, Bartual S, Mahasenan K, Lastochkin E, Pi H, Boggess B, Meindl K, Usón I, Fisher J, Mobashery S, Hermoso J. Structure and Cell Wall Cleavage by Modular Lytic Transglycosylase MltC of Escherichia coli. ACS Chemical Biology 2014, 9: 2058-2066. PMID: 24988330, PMCID: PMC4168783, DOI: 10.1021/cb500439c.Peer-Reviewed Original ResearchConceptsTwo-domain structureLytic transglycosylasesCell wall assemblyEscherichia coliEssential bacterial enzymeResolution X-ray structureÅ resolution X-ray structureGram-negative bacterium Escherichia coliBacterium Escherichia coliBacterial cell wallCell wall analoguesBacterial genomesGlycan strandsGenomic analysisActive siteCell wallBacterial enzymesFunctional roleSoluble constructWall assemblyGenomeTransglycosylasesExolytic cleavageX-ray structurePeptidoglycanDiscovery of a New Class of Non-β-lactam Inhibitors of Penicillin-Binding Proteins with Gram-Positive Antibacterial Activity
O’Daniel P, Peng Z, Pi H, Testero S, Ding D, Spink E, Leemans E, Boudreau M, Yamaguchi T, Schroeder V, Wolter W, Llarrull L, Song W, Lastochkin E, Kumarasiri M, Antunes N, Espahbodi M, Lichtenwalter K, Suckow M, Vakulenko S, Mobashery S, Chang M. Discovery of a New Class of Non-β-lactam Inhibitors of Penicillin-Binding Proteins with Gram-Positive Antibacterial Activity. Journal Of The American Chemical Society 2014, 136: 3664-3672. PMID: 24517363, PMCID: PMC3985699, DOI: 10.1021/ja500053x.Peer-Reviewed Original ResearchConceptsMethicillin-resistant Staphylococcus aureusPenicillin-binding protein 2aLinezolid-resistant methicillin-resistant Staphylococcus aureusNon-β-lactam antibioticsGlobal public health concernSerious global public health concernPublic health concernClasses of antibioticsMouse modelVivo efficacyOral bioavailabilityProtein 2ABactericidal activityGram-positive antibacterial activityStaphylococcus aureusNon-β-lactam inhibitorsInfectionPenicillin binding proteinsAntibioticsAntibacterial activityVancomycin