2016
Matrine compromises mouse sperm functions by a [Ca2+]i-related mechanism
Luo T, Zou Q, He Y, Wang H, Wang T, Liu M, Chen Y, Wang B. Matrine compromises mouse sperm functions by a [Ca2+]i-related mechanism. Reproductive Toxicology 2016, 60: 69-75. PMID: 26867864, DOI: 10.1016/j.reprotox.2016.02.003.Peer-Reviewed Original ResearchConceptsMouse sperm functionSperm functionDaily dosesIntraperitoneal injectionMale miceSperm countTestis weightReproductive toxicityMiceChinese medicineCatSper channelsMatrineProgressive motilityAcrosome reactionKey regulatorMouse spermTotal motilitySperm viabilityGene expressionTestis sizeMotilitySpermDoses
2015
Matrine Inhibits Mouse Sperm Function by Reducing Sperm [Ca2+]i and Phospho-ERK1/2
Luo T, Zou Q, He Y, Wang H, Li N, Zeng X. Matrine Inhibits Mouse Sperm Function by Reducing Sperm [Ca2+]i and Phospho-ERK1/2. Cellular Physiology And Biochemistry 2015, 35: 374-385. PMID: 25591778, DOI: 10.1159/000369703.Peer-Reviewed Original ResearchMeSH KeywordsAcrosome ReactionAlkaloidsAniline CompoundsAnimalsCalcimycinCalciumFemaleFertilization in VitroMaleMatrinesMiceMice, Inbred C57BLMicroscopy, FluorescenceMitogen-Activated Protein Kinase 1Mitogen-Activated Protein Kinase 3Patch-Clamp TechniquesPhosphorylationPotassiumQuinolizinesSperm MotilitySpermatozoaXanthenesConceptsMouse sperm functionIntracellular calcium concentrationSperm functionCauda epididymal spermMouse spermPhosphorylation of ERK1/2Acrosome reaction rateEpididymal spermMouse cauda epididymal spermFertilization abilityPharmacological effectsPotassium currentP-ERK1/2Phospho-ERK1/2Calcium concentrationChinese medicineKinase 1/2Male reproductionSignificant reductionMatrineMature mouse spermProgressive motilityAcrosome reactionMotilityTotal motility