2023
Reconstruction of private genomes through reference-based genotype imputation
Mosca M, Cho H. Reconstruction of private genomes through reference-based genotype imputation. Genome Biology 2023, 24: 271. PMID: 38053191, PMCID: PMC10698978, DOI: 10.1186/s13059-023-03105-6.Peer-Reviewed Original ResearchAssessing transcriptomic reidentification risks using discriminative sequence models
Sadhuka S, Fridman D, Berger B, Cho H. Assessing transcriptomic reidentification risks using discriminative sequence models. Genome Research 2023, 33: 1101-1112. PMID: 37541758, PMCID: PMC10538488, DOI: 10.1101/gr.277699.123.Peer-Reviewed Original ResearchConceptsExpression quantitative trait lociGene expression dataExpression dataQuantitative trait lociOmics data setsGene expression profilesTrait lociGenomic regionsGenetic variationGene expressionExpression profilesMolecular insightsLinkage disequilibriumFunctional impactGenotypesTranscriptomicsLociSame individualDisequilibriumSequenceExpressionPrevious studiesFull extentData sets
2021
Privacy-preserving genotype imputation in a trusted execution environment
Dokmai N, Kockan C, Zhu K, Wang X, Sahinalp S, Cho H. Privacy-preserving genotype imputation in a trusted execution environment. Cell Systems 2021, 12: 983-993.e7. PMID: 34450045, PMCID: PMC8542641, DOI: 10.1016/j.cels.2021.08.001.Peer-Reviewed Original ResearchConceptsTrusted Execution EnvironmentExecution environmentHardware-based solutionsSide-channel attacksIntel SGXEnhanced securityPrivacy concernsAnalysis servicesImputation ServerServer limitData resourcesImputation algorithmSGXServerImputation softwareGenomic data resourcesImputation accuracyGenotype imputationImputation strategiesServicesDownstream analysisScalabilityImputationEssential toolSecurity