2021
Bayesian information sharing enhances detection of regulatory associations in rare cell types
Wu A, Peng J, Berger B, Cho H. Bayesian information sharing enhances detection of regulatory associations in rare cell types. Bioinformatics 2021, 37: i349-i357. PMID: 34252956, PMCID: PMC8275330, DOI: 10.1093/bioinformatics/btab269.Peer-Reviewed Original ResearchMeSH KeywordsBayes TheoremGene Expression ProfilingInformation DisseminationSequence Analysis, RNASingle-Cell AnalysisSoftwareConceptsScRNA-seq datasetsRegulatory associationsCell typesRegulatory networksCell type-specific gene regulatory networksCell-type specific gene regulationSingle-cell RNA sequencing technologyCell-type specific networksBenchmark scRNA-seq datasetsDiverse cellular contextsGene regulatory network inference methodRNA sequencing technologyGene regulatory networksRare cell typesSingle-cell datasetsSpecific cell typesNetwork inference methodsDynamic biological processesTranscriptional statesGene regulationCellular contextNetwork inference algorithmsComplex rewiringBiological processesGene associations
2018
Generalizable and Scalable Visualization of Single-Cell Data Using Neural Networks
Cho H, Berger B, Peng J. Generalizable and Scalable Visualization of Single-Cell Data Using Neural Networks. Cell Systems 2018, 7: 185-191.e4. PMID: 29936184, PMCID: PMC6469860, DOI: 10.1016/j.cels.2018.05.017.Peer-Reviewed Original ResearchMeSH KeywordsAlgorithmsCluster AnalysisComputer GraphicsGenomicsHumansNeural Networks, ComputerSequence Analysis, RNASingle-Cell AnalysisSoftwareStochastic Processes
2014
High-Resolution Transcriptome Analysis with Long-Read RNA Sequencing
Cho H, Davis J, Li X, Smith K, Battle A, Montgomery S. High-Resolution Transcriptome Analysis with Long-Read RNA Sequencing. PLOS ONE 2014, 9: e108095. PMID: 25251678, PMCID: PMC4176000, DOI: 10.1371/journal.pone.0108095.Peer-Reviewed Original ResearchConceptsAllele-specific expressionTranscriptome analysisRNA sequencingAlternative splicing patternsCell line GM12878RNA-seq protocolsSequencing of cDNARNA-seq datasetsIndividual transcriptomesGenomic elementsAlternative splicingSplicing patternsAllelic expressionTranscript quantificationRead lengthMRNA transcriptsMapping biasSequencingExpressionTranscriptomeGM12878SplicingTechnical hurdlesCDNAGenes