2024
Secure Discovery of Genetic Relatives Across Large-Scale and Distributed Genomic Datasets
Hong M, Froelicher D, Magner R, Popic V, Berger B, Cho H. Secure Discovery of Genetic Relatives Across Large-Scale and Distributed Genomic Datasets. Lecture Notes In Computer Science 2024, 14758: 308-313. PMID: 39027313, PMCID: PMC11257153, DOI: 10.1007/978-1-0716-3989-4_19.Peer-Reviewed Original ResearchIdentity-by-descentMultiparty homomorphic encryptionGenomic datasetsPairwise sequence comparisonsPrivacy-preserving solutionsDegree of relatednessEffective hash functionsGenetic relationPairs of individualsRelatedness coefficientsSequence comparisonCryptographic techniquesHomomorphic encryptionPrivacy guaranteesHash functionPrivate dataFederated algorithmPrivacy concernsGenetic sequencesData silosRelation detectionEfficient algorithmMultiple entitiesBurden of operatorsPrivacy
2020
Privacy-Preserving Biomedical Database Queries with Optimal Privacy-Utility Trade-Offs
Cho H, Simmons S, Kim R, Berger B. Privacy-Preserving Biomedical Database Queries with Optimal Privacy-Utility Trade-Offs. Cell Systems 2020, 10: 408-416.e9. PMID: 32359425, DOI: 10.1016/j.cels.2020.03.006.Peer-Reviewed Original ResearchConceptsDifferential privacySensitive individual-level dataFormal privacy guaranteesQuery-answering systemPrivacy-utility tradePrivacy guaranteesQuery answersCount queriesCohort discoveryDatabase queriesUtility functionUse casesProof of optimalityResearch workflowAggregate insightsBiomedical databasesAccuracy improvementPrivate informationQueriesPrivacyGeneral utility functionDatabaseMore general utility functionsNew theoretical resultsLookup