2021
Efferent neurons control hearing sensitivity and protect hearing from noise through the regulation of gap junctions between cochlear supporting cells
Zhao H, Liu L, Yu N, Zhu Y, Mei L, Chen J, Liang C. Efferent neurons control hearing sensitivity and protect hearing from noise through the regulation of gap junctions between cochlear supporting cells. Journal Of Neurophysiology 2021, 127: 313-327. PMID: 34907797, PMCID: PMC8759971, DOI: 10.1152/jn.00468.2021.Peer-Reviewed Original ResearchConceptsOuter hair cellsActive cochlear amplificationCochlear efferent systemDistortion product otoacoustic emissionsEfferent systemEfferent pathwaysHearing sensitivityMedial olivocochlear efferent fibersPresynaptic vesicular acetylcholine transportersGap junctionsOlivocochlear efferent fibersHair cellsApplication of acetylcholineCochlear supporting cellsProtection of hearingVesicular acetylcholine transporterActive cochlear amplifierCochlear amplificationPostsynaptic ACh receptorsProduct otoacoustic emissionsMOC efferent systemHair cell activityEfferent nervesEfferent inhibitionEfferent fibersExcess extracellular K+ causes inner hair cell ribbon synapse degeneration
Zhao H, Zhu Y, Liu L. Excess extracellular K+ causes inner hair cell ribbon synapse degeneration. Communications Biology 2021, 4: 24. PMID: 33398038, PMCID: PMC7782724, DOI: 10.1038/s42003-020-01532-w.Peer-Reviewed Original ResearchConceptsCochlear synaptopathySynapse degenerationRibbon synapsesNoise exposureNoise-induced cochlear synaptopathyInner hair cell ribbon synapsesIHC ribbon synapsesGlutamate receptor agonistsBK channel blockersHair cell ribbon synapsesReceptor agonistFirst synapseChannel blockersHearing lossIHC ribbonsHearing disordersDegenerationBK channelsPotential targetSynaptopathyAuditory systemSynapsesExposureSwellingExcitotoxicity
2018
Knockout of Pannexin-1 Induces Hearing Loss
Chen J, Liang C, Zong L, Zhu Y, Zhao H. Knockout of Pannexin-1 Induces Hearing Loss. International Journal Of Molecular Sciences 2018, 19: 1332. PMID: 29710868, PMCID: PMC5983795, DOI: 10.3390/ijms19051332.Peer-Reviewed Original ResearchConceptsDistortion product otoacoustic emissionsHearing lossKO miceKO mouse lineMouse linesCochlear microphonicsAuditory brainstem response thresholdActive cochlear amplificationPanx1 KO miceAuditory function testsProduct otoacoustic emissionsKnockout mouse lineFunction testsNonsyndromic hearing lossABR thresholdHearing functionHigh incidenceRecent studiesGap junctional proteinReceptor currentsOtoacoustic emissionsMiceCochlear amplificationConsistent phenotypeResponse threshold
2013
The effects and outcomes of electrolyte disturbances and asphyxia on newborns hearing
Liang C, Hong Q, Jiang T, Gao Y, Yao X, Luo X, Zhuo X, Shinn J, Jones R, Zhao H, Lu G. The effects and outcomes of electrolyte disturbances and asphyxia on newborns hearing. International Journal Of Pediatric Otorhinolaryngology 2013, 77: 1072-1076. PMID: 23648318, PMCID: PMC3738180, DOI: 10.1016/j.ijporl.2013.03.031.Peer-Reviewed Original ResearchConceptsElectrolyte disturbancesInfant HearingTEOAE testHearing outcomesFull-term infantsOtoacoustic emission testHigh-risk factorsMonths of agePreterm infantsNewborn hearingAsphyxiaSignificant impairmentInfantsHypocalcaemiaPass rateSignificant reductionOutcomesHearingLow recovery ratesNewbornsImpairmentRecovery rateMonthsMutation of the ATP-gated P2X2 receptor leads to progressive hearing loss and increased susceptibility to noise
Yan D, Zhu Y, Walsh T, Xie D, Yuan H, Sirmaci A, Fujikawa T, Wong A, Loh T, Du L, Grati M, Vlajkovic S, Blanton S, Ryan A, Chen Z, Thorne P, Kachar B, Tekin M, Zhao H, Housley G, King M, Liu X. Mutation of the ATP-gated P2X2 receptor leads to progressive hearing loss and increased susceptibility to noise. Proceedings Of The National Academy Of Sciences Of The United States Of America 2013, 110: 2228-2233. PMID: 23345450, PMCID: PMC3568371, DOI: 10.1073/pnas.1222285110.Peer-Reviewed Original ResearchMeSH KeywordsAdenosine TriphosphateAmino Acid SequenceAnimalsDisease Models, AnimalEvoked Potentials, AuditoryFemaleGenes, DominantHearing Loss, Noise-InducedHearing Loss, SensorineuralHeterozygoteHumansIon Channel GatingMaleMiceMice, Inbred C57BLMice, KnockoutMolecular Sequence DataMutation, MissensePedigreePenetranceReceptors, Purinergic P2X2Sequence Homology, Amino AcidYoung AdultConceptsHigh-frequency hearing lossHearing lossNoise-induced hearing lossAge-related hearing lossProgressive hearing lossSevere progressive hearing lossCoexpression of mutantLoss of ATPLoss of functionNoise exposureNormal hearingReceptor subunitsHuman morbidityP2X2 receptorsMajor causeYoung adultsYoung adulthoodEarly exposureHallmark featureFamily membersReceptorsExposureIndex familyShared causeCause
2004
Paradoxical Enhancement of Active Cochlear Mechanics in Long-Term Administration of Salicylate
Huang Z, Luo Y, Wu Z, Tao Z, Jones R, Zhao H. Paradoxical Enhancement of Active Cochlear Mechanics in Long-Term Administration of Salicylate. Journal Of Neurophysiology 2004, 93: 2053-2061. PMID: 15590729, DOI: 10.1152/jn.00959.2004.Peer-Reviewed Original ResearchConceptsDistortion product otoacoustic emissionsLong-term administrationOtotoxic mechanismsLong-term salicylate administrationAwake guinea pigsReversible hearing lossSalicylate-induced tinnitusActive cochlear mechanicsProduct otoacoustic emissionsInitial normal levelsDistortion productsSalicylate administrationSodium salicylateDaily injectionsSaline injectionHearing functionHearing lossCubic distortion productSingle injectionControl animalsOHC levelsCommon drugsSalicylate treatmentAcoustic emissionRate of recovery
2001
Chlorpromazine Alters Outer Hair Cell Electromotility
Lue A, Zhao H, Brownell W. Chlorpromazine Alters Outer Hair Cell Electromotility. Otolaryngology 2001, 125: 71-76. PMID: 11458218, DOI: 10.1067/mhn.2001.116446.Peer-Reviewed Original ResearchConceptsOuter hair cellsHair cellsDose-dependent depolarizationGuinea pig outer hair cellsEffect of chlorpromazineElectromotile responseAntipsychotic medicationChlorpromazine treatmentHearing thresholdsLarge dosesCochlear sensitivityOtoacoustic emissionsInner earChlorpromazineOuter Hair Cell ElectromotilityHair cell electromotilityOHC electromotilityMembrane voltageRecording conditionsCellsMedicationsResponseElectromotility