Hemichannel-Mediated Inositol 1,4,5-Trisphosphate (IP3) Release in the Cochlea: A Novel Mechanism of IP3 Intercellular Signaling
Gossman D, Zhao H. Hemichannel-Mediated Inositol 1,4,5-Trisphosphate (IP3) Release in the Cochlea: A Novel Mechanism of IP3 Intercellular Signaling. Cell Communication & Adhesion 2008, 15: 305-315. PMID: 18979296, PMCID: PMC5543712, DOI: 10.1080/15419060802357217.Peer-Reviewed Original ResearchConceptsIntercellular signalingLong-distance intercellular communicationImportant second messengerGap junction channelsGap junction hemichannel blockerGap junction hemichannelsCochlear sensory epitheliumCassette transportersSecond messengerIntercellular communicationDeafness mutantsJunction channelsCell surfaceExtracellular mediatorsSignalingNovel mechanismSensory epitheliumHemichannelsExtracellular pathwaysTrisphosphateInositolFluorescence polarization techniqueHemichannel blockersImportant roleExtracellular application