2024
Bipolar symptoms, somatic burden and functioning in older‐age bipolar disorder: A replication study from the global aging & geriatric experiments in bipolar disorder database (GAGE‐BD) project
Sajatovic M, Rej S, Almeida O, Altinbas K, Balanzá‐Martínez V, Barbosa I, Beunders A, Blumberg H, Briggs F, Dols A, Forester B, Forlenza O, Gildengers A, Jimenez E, Klaus F, Lafer B, Mulsant B, Mwangi B, Nunes P, Olagunju A, Oluwaniyi S, Orhan M, Patrick R, Radua J, Rajji T, Sarna K, Schouws S, Simhandl C, Sekhon H, Soares J, Sutherland A, Teixeira A, Tsai S, Vidal‐Rubio S, Vieta E, Yala J, Eyler L. Bipolar symptoms, somatic burden and functioning in older‐age bipolar disorder: A replication study from the global aging & geriatric experiments in bipolar disorder database (GAGE‐BD) project. International Journal Of Geriatric Psychiatry 2024, 39: e6057. PMID: 38511929, DOI: 10.1002/gps.6057.Peer-Reviewed Original ResearchMeSH KeywordsAgedAgingBipolar DisorderDatabases, FactualFemaleHumansMaleManiaMedically Unexplained SymptomsMiddle AgedConceptsOlder age bipolar disorderBipolar Disorder DatabaseSomatic burdenBipolar disorderGAGE-BDAssociated with worse functionSymptom severityBD symptomsAssociated with depression severityOlder-age bipolar disorderGlobal Aging & Geriatric ExperimentsManic symptom severityAssociated with poorer functioningGeriatric experiencesAssociation of depressionBipolar symptomsSevere maniaDepression severityDepressive symptomsLow functioningSomatic conditionsPoor functionWorse functionArchival datasetWave 2Sociodemographic and clinical characteristics of people with oldest older age bipolar disorder in a global sample: Results from the global aging and geriatric experiments in bipolar disorder project
Chen P, Sajatovic M, Briggs F, Mulsant B, Dols A, Gildengers A, Yala J, Beunders A, Blumberg H, Rej S, Forlenza O, Jimenez E, Schouws S, Orhan M, Sutherland A, Vieta E, Tsai S, Sarna K, Eyler L, Investigators T. Sociodemographic and clinical characteristics of people with oldest older age bipolar disorder in a global sample: Results from the global aging and geriatric experiments in bipolar disorder project. International Journal Of Geriatric Psychiatry 2024, 39: e6073. PMID: 38393311, DOI: 10.1002/gps.6073.Peer-Reviewed Original ResearchMeSH KeywordsAgedAgingBipolar DisorderCluster AnalysisCross-Sectional StudiesDatabases, FactualHumansConceptsOlder age bipolar disorderBipolar disorderGAGE-BDSeverity of manic symptomsRates of suicidal thoughtsLower depressive symptomsComorbid physical conditionsClinical characteristics of peopleGeriatric experiencesManic symptomsClinical characteristicsDepressive symptomsSuicidal thoughtsCharacteristics of peoplePhysical burdenDisordersGlobal ageMedical burdenAge categoriesLogistic regression modelsMultinomial logistic regression modelCross-sectional analysisYounger groupMusculoskeletal domainsSymptomsBlood epigenome-wide association studies of suicide attempt in adults with bipolar disorder
Mirza S, Lima C, Del Favero-Campbell A, Rubinstein A, Topolski N, Cabrera-Mendoza B, Kovács E, Blumberg H, Richards J, Williams A, Wemmie J, Magnotta V, Fiedorowicz J, Gaine M, Walss-Bass C, Quevedo J, Soares J, Fries G. Blood epigenome-wide association studies of suicide attempt in adults with bipolar disorder. Translational Psychiatry 2024, 14: 70. PMID: 38296944, PMCID: PMC10831084, DOI: 10.1038/s41398-024-02760-y.Peer-Reviewed Original ResearchMeSH KeywordsAdultBipolar DisorderDNA MethylationEpigenesis, GeneticEpigenomeGenome-Wide Association StudyHumansSuicide, AttemptedConceptsEpigenome-wide association studiesDifferentially methylated regionsDifferentially methylated positionsAssociation studiesCo-methylation network analysisBipolar disorderDNA methylation patternsSuicide attemptsReplication cohortHistory of SAGene ontology analysisSignificant CpG sitesMethylation patternsDNA methylationCpG sitesOntology analysisImmune-related genesEnrichment analysisNon-psychiatric controlsCalcium signalingGenesDNAClinical interviewSA historyNetwork analysis
2023
Demographic and clinical associations to employment status in older‐age bipolar disorder: Analysis from the GAGE‐BD database project
Mallu A, Chan C, Eyler L, Dols A, Rej S, Blumberg H, Sarna K, Forester B, Patrick R, Forlenza O, Jimenez E, Vieta E, Schouws S, Sutherland A, Yala J, Briggs F, Sajatovic M. Demographic and clinical associations to employment status in older‐age bipolar disorder: Analysis from the GAGE‐BD database project. Bipolar Disorders 2023, 25: 637-647. PMID: 37798096, PMCID: PMC10843228, DOI: 10.1111/bdi.13381.Peer-Reviewed Original ResearchEssential data dimensions for prospective international data collection in older age bipolar disorder (OABD): Recommendations from the GAGE‐BD group
Lavin P, Rej S, Olagunju A, Teixeira A, Dols A, Alda M, Almeida O, Altinbas K, Balanzá‐Martínez V, Barbosa I, Blumberg H, Briggs F, Calkin C, Cassidy K, Forester B, Forlenza O, Hajek T, Haarman B, Jimenez E, Lafer B, Mulsant B, Oluwaniyi S, Patrick R, Radua J, Schouws S, Sekhon H, Simhandl C, Soares J, Tsai S, Vieta E, Villa L, Sajatovic M, Eyler L. Essential data dimensions for prospective international data collection in older age bipolar disorder (OABD): Recommendations from the GAGE‐BD group. Bipolar Disorders 2023, 25: 554-563. PMID: 36843436, DOI: 10.1111/bdi.13312.Peer-Reviewed Original ResearchConceptsOlder age bipolar disorderBipolar disorderGeneral medical comorbidityGeriatric mental healthSubgroup of patientsInternational data collectionSubjective cognitive functionMedical comorbiditiesCurrent medicationsPsychiatric comorbidityFamily historyDelphi consensusPsychotic symptomsBD diagnosisClinical practiceSystematic reviewCognitive functionCore symptomsMental healthGlobal AGEingComorbiditiesDisordersSymptomsInitial recommendationsData collection
2022
Aging of the brain in bipolar disorder: Illness- and onset-related effects in cortical thickness and subcortical gray matter volume
Villa L, Colic L, Kim J, Sankar A, Goldman D, Lessing B, Pittman B, Alexopoulos G, van Dyck C, Blumberg H. Aging of the brain in bipolar disorder: Illness- and onset-related effects in cortical thickness and subcortical gray matter volume. Journal Of Affective Disorders 2022, 323: 875-883. PMID: 36526112, PMCID: PMC9839524, DOI: 10.1016/j.jad.2022.12.026.Peer-Reviewed Original ResearchMeSH KeywordsBipolar DisorderBrainCross-Sectional StudiesGray MatterHumansMagnetic Resonance ImagingConceptsGray matter volumeOccipital cortical thicknessSubcortical gray matter volumesCortical thicknessBipolar disorderMatter volumeOlder adultsOnset of BDIndividuals age 40Striatal gray matter volumeGray matter reductionsOnset bipolar disorderGray matter decreasesPrefrontal cortical thicknessStructural brain differencesHigh suicide riskCross-sectional designHealthy controlsCognitive dysfunctionTreatment resistanceAge 40Striatal volumeSevere symptomsSuicide attempt historySuicide attemptsBipolar I and bipolar II subtypes in older age: Results from the Global Aging and Geriatric Experiments in Bipolar Disorder (GAGE‐BD) project
Beunders A, Klaus F, Kok A, Schouws S, Kupka R, Blumberg H, Briggs F, Eyler L, Forester B, Forlenza O, Gildengers A, Jimenez E, Mulsant B, Patrick R, Rej S, Sajatovic M, Sarna K, Sutherland A, Yala J, Vieta E, Villa L, Korten N, Dols A. Bipolar I and bipolar II subtypes in older age: Results from the Global Aging and Geriatric Experiments in Bipolar Disorder (GAGE‐BD) project. Bipolar Disorders 2022, 25: 43-55. PMID: 36377516, PMCID: PMC10265276, DOI: 10.1111/bdi.13271.Peer-Reviewed Original ResearchConceptsBD II patientsStudy cohortBD subtypesSomatic burdenMultivariable analysisGeneral functioningBD-IIGlobal AGEingBD-I patientsCross-sectional analysisClinical factorsClinical differencesSevere depressionPsychiatric hospitalizationBipolar ICognitive impairmentLate onsetPatientsOlder ageDiagnostic definitionSubtypesGeneralized linear mixed modelCohortLinear mixed modelsRandom interceptDifferences in Quantification of the Metabotropic Glutamate Receptor 5 Across Bipolar Disorder and Major Depressive Disorder
Holmes S, Asch R, Davis M, DellaGioia N, Pashankar N, Gallezot J, Nabulsi N, Matuskey D, Sanacora G, Carson R, Blumberg H, Esterlis I. Differences in Quantification of the Metabotropic Glutamate Receptor 5 Across Bipolar Disorder and Major Depressive Disorder. Biological Psychiatry 2022, 93: 1099-1107. PMID: 36764853, PMCID: PMC10164841, DOI: 10.1016/j.biopsych.2022.10.018.Peer-Reviewed Original ResearchConceptsMajor depressive disorderMetabotropic glutamate receptor 5Glutamate receptor 5MGluR5 availabilityBipolar disorderPositron emission tomographyHC groupDepressive disorderReceptor 5Emission tomographyHealthy control individualsPossible treatment targetsGlutamate transmissionBD depressionTreatment strategiesBD groupMGluR5Depressive symptomsNovel treatmentsCognitive alterationsTreatment targetsSynaptic plasticityControl individualsAccurate diagnosisSignificant negative correlationA graph theory neuroimaging approach to distinguish the depression of bipolar disorder from major depressive disorder in adolescents and young adults
Goldman DA, Sankar A, Rich A, Kim JA, Pittman B, Constable RT, Scheinost D, Blumberg HP. A graph theory neuroimaging approach to distinguish the depression of bipolar disorder from major depressive disorder in adolescents and young adults. Journal Of Affective Disorders 2022, 319: 15-26. PMID: 36103935, PMCID: PMC9669784, DOI: 10.1016/j.jad.2022.09.016.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentBipolar DisorderBrainDepressive Disorder, MajorHumansMagnetic Resonance ImagingNeuroimagingYoung AdultConceptsAdolescents/young adultsMajor depressive disorderDepressive disorderYoung adultsICD increasesBipolar disorderInterhemispheric functional connectivityFunctional connectivity differencesSeed-based analysisFunctional connectivity patternsSeed-based connectivityFunctional magnetic resonanceFunctional connectivity measuresBasal gangliaFunctional dysconnectivityIllness progressionTreatment strategiesClinical measuresEarly diagnosisHC groupTargeted treatmentConnectivity differencesSuicide thoughtsFunctional connectivityDeleterious treatmentGender-related association among childhood maltreatment, brain structure and clinical features in bipolar disorder
Colic L, Clark A, Sankar A, Rathi DJ, Goldman DA, Kim JA, Villa LM, Edmiston EK, Lippard ETC, Pittman B, Constable RT, Mazure CM, Blumberg HP. Gender-related association among childhood maltreatment, brain structure and clinical features in bipolar disorder. European Neuropsychopharmacology 2022, 63: 35-46. PMID: 36037590, PMCID: PMC9593266, DOI: 10.1016/j.euroneuro.2022.07.186.Peer-Reviewed Original ResearchMeSH KeywordsAdultBipolar DisorderBrainChildChild AbuseFemaleGray MatterHumansMagnetic Resonance ImagingMalePrefrontal CortexConceptsClinical featuresBipolar disorderCM severityChildhood maltreatmentLeft hippocampusPost-traumatic stress disorder (PTSD) comorbidityBrain structuresStructural magnetic resonance imagingGender-related associationMagnetic resonance imagingGray matter structuresChildhood Trauma QuestionnaireGender-related differencesCM exposureHealthy controlsClinical assessmentDisorder comorbidityMood symptomsPathophysiological modelGender-related effectsResonance imagingHippocampusFrontal poleTrauma QuestionnaireSeverityDemographic and clinical characteristics of lithium‐treated older adults with bipolar disorder
Forlenza OV, Hajek T, Almeida OP, Beunders AJM, Blumberg HP, Briggs FBS, De‐Paula V, Dols A, Eyler LT, Forester BP, Gildengers A, Jimenez E, Korten NCM, Lafer B, McWhinney SR, Mulsant B, Rej S, Sarna K, Schouws S, Sutherland A, Tsai S, Vieta E, Yala J, Sajatovic M, initiative G. Demographic and clinical characteristics of lithium‐treated older adults with bipolar disorder. Acta Psychiatrica Scandinavica 2022, 146: 442-455. PMID: 35837985, PMCID: PMC9588573, DOI: 10.1111/acps.13474.Peer-Reviewed Original ResearchMeSH KeywordsAgedAntipsychotic AgentsBipolar DisorderDemographyFemaleHumansLithiumLithium CompoundsMaleMiddle AgedConceptsLithium usersBipolar disorderClinical characteristicsOlder adultsDepression Rating ScaleCross-sectional analysisGlobal cognitive stateCardiovascular comorbiditiesCross-sectional approachClinical profileMood stabilizersLithium therapySevere depressionPsychiatric diagnosisRating ScaleCurrent prescriptionGlobal AGEingDisordersRapid cyclingAdultsRelevant differencesSafety concernsLower scoresCurrent useMethodological limitationsComparing continuous and harmonized measures of depression severity in older adults with bipolar disorder: Relationship to functioning
Orhan M, Millett C, Klaus F, Blumberg HP, Briggs F, Chung KH, Korten N, McManus K, van Oppen P, Patrick RE, Sarna K, Sutherland A, Tsai SY, Villa LM, Yala J, Sajatovic M, Burdick KE, Eyler L, Dols A, consortium T. Comparing continuous and harmonized measures of depression severity in older adults with bipolar disorder: Relationship to functioning. Journal Of Affective Disorders 2022, 314: 44-49. PMID: 35803392, DOI: 10.1016/j.jad.2022.06.074.Peer-Reviewed Original ResearchDemographic and Clinical Characteristics of Antipsychotic Drug-Treated Older Adults with Bipolar Disorder from the Global Aging & Geriatric Experiments in Bipolar Disorder Database (GAGE-BD).
Chen P, Eyler LT, Gildengers A, Beunders AJ, Blumberg HP, Briggs FB, Dols A, Rej S, Forlenza OV, Jimenez E, Mulsant B, Schouws S, Orhan M, Sarna K, Sutherland AN, Vieta E, Tsai S, Yala J, Villa LM, Sajatovic M. Demographic and Clinical Characteristics of Antipsychotic Drug-Treated Older Adults with Bipolar Disorder from the Global Aging & Geriatric Experiments in Bipolar Disorder Database (GAGE-BD). Psychopharmacology Bulletin 2022, 52: 8-33. PMID: 35721813, PMCID: PMC9172555.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAgingAntipsychotic AgentsBipolar DisorderCross-Sectional StudiesDemographyFemaleHumansMaleMiddle AgedConceptsOlder age bipolar disorderFirst-generation antipsychoticsAntipsychotic drugsBipolar disorderPsychiatric hospitalizationMean age 63.2 yearsGlobal AGEingClinical characteristicsFrequent hospitalizationsClinical variablesSevere illnessTreatment statusGreater burdenHospitalizationDisorder databaseOlder adultsCross-sectional dataLongitudinal outcomesDisordersPatientsGeneralized mixed modelMultivariate model resultsInternational studiesDrugsObservational analysisSymptom Severity Mixity in Older-Age Bipolar Disorder: Analyses From the Global Aging and Geriatric Experiments in Bipolar Disorder Database (GAGE-BD)
Eyler LT, Briggs FBS, Dols A, Rej S, Almeida OP, Beunders AJM, Blumberg HP, Forester BP, Patrick RE, Forlenza OV, Gildengers A, Jimenez E, Vieta E, Mulsant BH, Schouws S, Paans NPG, Strejilevich S, Sutherland A, Tsai S, Sajatovic M. Symptom Severity Mixity in Older-Age Bipolar Disorder: Analyses From the Global Aging and Geriatric Experiments in Bipolar Disorder Database (GAGE-BD). American Journal Of Geriatric Psychiatry 2022, 30: 1096-1107. PMID: 35637088, PMCID: PMC10280310, DOI: 10.1016/j.jagp.2022.03.007.Peer-Reviewed Original ResearchPredictors of functional impairment in bipolar disorder: Results from 13 cohorts from seven countries by the global bipolar cohort collaborative
Burdick KE, Millett CE, Yocum AK, Altimus CM, Andreassen OA, Aubin V, Belzeaux R, Berk M, Biernacka JM, Blumberg H, Cleare AJ, Diaz‐Byrd C, Dubertret C, Etain B, Eyler LT, Forester BP, Fullerton JM, Frye MA, Gard S, Godin O, Haffen E, Klaus F, Lagerberg TV, Leboyer M, Martinez‐Aran A, McElroy S, Mitchell PB, Olie E, Olorunfemi P, Passerieux C, Peters AT, Pham DL, Polosan M, Potter JR, Sajatovic M, Samalin L, Schwan R, Shanahan M, Solé B, Strawbridge R, Stuart AL, Torres I, Ueland T, Vieta E, Williams LJ, Wrobel AL, Yatham LN, Young AH, Nierenberg AA, McInnis MG. Predictors of functional impairment in bipolar disorder: Results from 13 cohorts from seven countries by the global bipolar cohort collaborative. Bipolar Disorders 2022, 24: 709-719. PMID: 35322518, PMCID: PMC9500115, DOI: 10.1111/bdi.13208.Peer-Reviewed Original ResearchConceptsBipolar disorderFunctional impairmentComplete recoveryComorbid substance use disorderPersistent functional impairmentPatient's complete recoveryPrior mood episodesLogistic regression analysisProspective longitudinal studySubstance use disordersPsychotropic medicationsHeterogeneous presentationBipolar cohortMood episodesClinical research communityDepressive symptomsOptimizing outcomesUse disordersCohortLower functioningImpairmentLongitudinal studyDisordersRegression analysisGreater total numberToward low‐risk approaches to prevent bipolar disorder in at‐risk youth
Goldman DA, Blumberg HP. Toward low‐risk approaches to prevent bipolar disorder in at‐risk youth. Bipolar Disorders 2022, 24: 322-323. PMID: 35181984, PMCID: PMC9167252, DOI: 10.1111/bdi.13194.Peer-Reviewed Original ResearchRethinking “aggression” and impulsivity in bipolar disorder: Risk, clinical and brain circuitry features
Drachman R, Colic L, Sankar A, Spencer L, Goldman DA, Villa LM, Kim JA, Oquendo MA, Pittman B, Blumberg HP. Rethinking “aggression” and impulsivity in bipolar disorder: Risk, clinical and brain circuitry features. Journal Of Affective Disorders 2022, 303: 331-339. PMID: 35181384, PMCID: PMC9109470, DOI: 10.1016/j.jad.2022.02.047.Peer-Reviewed Original ResearchMeSH KeywordsAdultAggressionBipolar DisorderBrainFemaleGray MatterHumansImpulsive BehaviorMaleSubstance-Related DisordersConceptsSubstance use disordersChildhood Trauma QuestionnaireChildhood maltreatmentBarratt Impulsiveness Scale scoresBipolar disorderAnterior cingulate cortexEmotional childhood maltreatmentElevated mood statesBIS total scoreBilateral orbitofrontal cortexMotor impulsivenessSuicide attemptsOrbitofrontal cortexImpulsiveness scoresMood statesBehavioral dyscontrolCingulate cortexBehavioral constructsTrauma QuestionnaireBrain circuitrySocial behaviorElevated aggressionModest sample sizeBrain regionsSuicide ideationGraph theory analysis of whole brain functional connectivity to assess disturbances associated with suicide attempts in bipolar disorder
Sankar A, Scheinost D, Goldman DA, Drachman R, Colic L, Villa LM, Kim JA, Gonzalez Y, Marcelo I, Shinomiya M, Pittman B, Lacadie CM, Oquendo MA, Constable RT, Blumberg HP. Graph theory analysis of whole brain functional connectivity to assess disturbances associated with suicide attempts in bipolar disorder. Translational Psychiatry 2022, 12: 7. PMID: 35013103, PMCID: PMC8748935, DOI: 10.1038/s41398-021-01767-z.Peer-Reviewed Original ResearchMeSH KeywordsAdultBipolar DisorderBrainHumansMagnetic Resonance ImagingPrefrontal CortexSuicide, AttemptedConceptsIntrinsic connectivity distributionBipolar disorderSuicide attemptsHealthy volunteersFunctional connectivity disturbancesSuicide behaviorWhole-brain functional connectivityPrior suicide attemptsRight anterior insulaBrain functional connectivitySuicidal ideation severityBilateral ventromedial prefrontal cortexFunctional magnetic resonanceSignificant group differencesTemporopolar cortexConnectivity disturbancesBrain targetsFC differencesHigh riskCerebellar cortexVentromedial prefrontal cortexSuicidal ideationOrbitofrontal cortexFunctional connectivitySuicide riskCognition in older adults with bipolar disorder: An ISBD task force systematic review and meta‐analysis based on a comprehensive neuropsychological assessment
Montejo L, Torrent C, Jiménez E, Martínez‐Arán A, Blumberg HP, Burdick KE, Chen P, Dols A, Eyler LT, Forester BP, Gatchel JR, Gildengers A, Kessing LV, Miskowiak KW, Olagunju AT, Patrick RE, Schouws S, Radua J, del M. Bonnín C, Vieta E, Force I. Cognition in older adults with bipolar disorder: An ISBD task force systematic review and meta‐analysis based on a comprehensive neuropsychological assessment. Bipolar Disorders 2022, 24: 115-136. PMID: 34978124, DOI: 10.1111/bdi.13175.Peer-Reviewed Original ResearchMeSH KeywordsAgedBipolar DisorderCognitionCognitive DysfunctionHumansMemory, Short-TermMiddle AgedNeuropsychological TestsConceptsComprehensive neuropsychological assessmentNeuropsychological assessmentCognitive domainsExecutive functionProcessing speedAttention/processing speedOlder adultsDetailed neuropsychological profileEuthymic older adultsComplete neuropsychological assessmentEffect sizeModerate effect sizeCognitive flexibilityVerbal learningMemory domainImmediate memoryVerbal fluencyCognitive performanceNeuropsychological profileOABD patientsSignificant effect sizeBipolar disorderCognitive functionOABDLarge significant effect sizes
2021
Physical Health Burden Among Older Men and Women With Bipolar Disorder: Results From the Gage-Bd Collaboration
Almeida OP, Dols A, Blanken MAJT, Rej S, Blumberg HP, Villa L, Forester BP, Forlenza OV, Gildengers A, Vieta E, Jimenez E, Mulsant B, Schouws S, Tsai S, Korten NCM, Sutherland A, Briggs FBS, Flicker L, Eyler LT, Sajatovic M. Physical Health Burden Among Older Men and Women With Bipolar Disorder: Results From the Gage-Bd Collaboration. American Journal Of Geriatric Psychiatry 2021, 30: 727-732. PMID: 34980553, DOI: 10.1016/j.jagp.2021.12.006.Peer-Reviewed Original ResearchMeSH KeywordsAgedAgingBipolar DisorderCross-Sectional StudiesDatabases, FactualFemaleHumansMalePrevalenceConceptsBipolar disorderPhysical morbidityEndocrinological systemMore menMore womenEvidence of morbidityPhysical health burdenAdult bipolar disorderOutcomes of interestCross-sectional analysisEndocrinological diseasesHealth burdenOlder menMan studyMorbidityWomenGlobal AGEingMenDisordersDiseaseDisorder databaseYearsPrevalence