2022
Rethinking “aggression” and impulsivity in bipolar disorder: Risk, clinical and brain circuitry features
Drachman R, Colic L, Sankar A, Spencer L, Goldman DA, Villa LM, Kim JA, Oquendo MA, Pittman B, Blumberg HP. Rethinking “aggression” and impulsivity in bipolar disorder: Risk, clinical and brain circuitry features. Journal Of Affective Disorders 2022, 303: 331-339. PMID: 35181384, PMCID: PMC9109470, DOI: 10.1016/j.jad.2022.02.047.Peer-Reviewed Original ResearchConceptsSubstance use disordersChildhood Trauma QuestionnaireChildhood maltreatmentBarratt Impulsiveness Scale scoresBipolar disorderAnterior cingulate cortexEmotional childhood maltreatmentElevated mood statesBIS total scoreBilateral orbitofrontal cortexMotor impulsivenessSuicide attemptsOrbitofrontal cortexImpulsiveness scoresMood statesBehavioral dyscontrolCingulate cortexBehavioral constructsTrauma QuestionnaireBrain circuitrySocial behaviorElevated aggressionModest sample sizeBrain regionsSuicide ideationGraph theory analysis of whole brain functional connectivity to assess disturbances associated with suicide attempts in bipolar disorder
Sankar A, Scheinost D, Goldman DA, Drachman R, Colic L, Villa LM, Kim JA, Gonzalez Y, Marcelo I, Shinomiya M, Pittman B, Lacadie CM, Oquendo MA, Constable RT, Blumberg HP. Graph theory analysis of whole brain functional connectivity to assess disturbances associated with suicide attempts in bipolar disorder. Translational Psychiatry 2022, 12: 7. PMID: 35013103, PMCID: PMC8748935, DOI: 10.1038/s41398-021-01767-z.Peer-Reviewed Original ResearchConceptsIntrinsic connectivity distributionBipolar disorderSuicide attemptsHealthy volunteersFunctional connectivity disturbancesSuicide behaviorWhole-brain functional connectivityPrior suicide attemptsRight anterior insulaBrain functional connectivitySuicidal ideation severityBilateral ventromedial prefrontal cortexFunctional magnetic resonanceSignificant group differencesTemporopolar cortexConnectivity disturbancesBrain targetsFC differencesHigh riskCerebellar cortexVentromedial prefrontal cortexSuicidal ideationOrbitofrontal cortexFunctional connectivitySuicide risk
2017
Multimodal Neuroimaging of Frontolimbic Structure and Function Associated With Suicide Attempts in Adolescents and Young Adults With Bipolar Disorder
Johnston JAY, Wang F, Liu J, Blond BN, Wallace A, Liu J, Spencer L, Cox Lippard ET, Purves KL, Landeros-Weisenberger A, Hermes E, Pittman B, Zhang S, King R, Martin A, Oquendo MA, Blumberg HP. Multimodal Neuroimaging of Frontolimbic Structure and Function Associated With Suicide Attempts in Adolescents and Young Adults With Bipolar Disorder. American Journal Of Psychiatry 2017, 174: 667-675. PMID: 28135845, PMCID: PMC5939580, DOI: 10.1176/appi.ajp.2016.15050652.Peer-Reviewed Original ResearchConceptsGray matter volumeBipolar disorderWhite matter integrityFunctional connectivityMatter volumeSuicide attemptsAttempt lethalityPrefrontal connectivitySuicidal ideationYoung adult suicide attemptersAmygdala-prefrontal functional connectivityYoung adultsAmygdala functional connectivitySuicide-related symptomsAdult suicide attemptersPrior suicide attemptsRegional gray matter volumeFrontolimbic structuresNonattempter groupFrontolimbic systemsHigh riskSignificant negative correlationFunctional MROrbitofrontal cortexSuicidal behavior
2006
The role of the ventral prefrontal cortex in mood disorders
Fredericks C, Kalmar J, Blumberg H. The role of the ventral prefrontal cortex in mood disorders. 2006, 545-578. DOI: 10.1093/acprof:oso/9780198565741.003.0021.Peer-Reviewed Original ResearchVentral prefrontal cortexMood disordersPrefrontal cortexPregenual anterior cingulateLateral orbitofrontal cortexRostral frontal cortexMajor depressionFrontal cortexAnterior cingulateBipolar disorderOrbitofrontal cortexBrain structuresCortexDisordersMultiple studiesSpecific subregionsNeural systemsSignificant connectivityNeuropathophysiologyCingulate