2022
Structural brain alterations associated with suicidal thoughts and behaviors in young people: results from 21 international studies from the ENIGMA Suicidal Thoughts and Behaviours consortium
van Velzen LS, Dauvermann MR, Colic L, Villa LM, Savage HS, Toenders YJ, Zhu AH, Bright JK, Campos AI, Salminen LE, Ambrogi S, Ayesa-Arriola R, Banaj N, Başgöze Z, Bauer J, Blair K, Blair RJ, Brosch K, Cheng Y, Colle R, Connolly CG, Corruble E, Couvy-Duchesne B, Crespo-Facorro B, Cullen KR, Dannlowski U, Davey CG, Dohm K, Fullerton JM, Gonul AS, Gotlib IH, Grotegerd D, Hahn T, Harrison BJ, He M, Hickie IB, Ho TC, Iorfino F, Jansen A, Jollant F, Kircher T, Klimes-Dougan B, Klug M, Leehr EJ, Lippard ETC, McLaughlin KA, Meinert S, Miller AB, Mitchell PB, Mwangi B, Nenadić I, Ojha A, Overs BJ, Pfarr JK, Piras F, Ringwald KG, Roberts G, Romer G, Sanches M, Sheridan MA, Soares JC, Spalletta G, Stein F, Teresi GI, Tordesillas-Gutiérrez D, Uyar-Demir A, van der Wee NJA, van der Werff SJ, Vermeiren RRJM, Winter A, Wu MJ, Yang TT, Thompson PM, Rentería ME, Jahanshad N, Blumberg HP, van Harmelen AL, Schmaal L. Structural brain alterations associated with suicidal thoughts and behaviors in young people: results from 21 international studies from the ENIGMA Suicidal Thoughts and Behaviours consortium. Molecular Psychiatry 2022, 27: 4550-4560. PMID: 36071108, PMCID: PMC9734039, DOI: 10.1038/s41380-022-01734-0.Peer-Reviewed Original ResearchConceptsMood disordersSuicidal thoughtsSuicide attemptsBrain alterationsMRI metricsSuicidal ideationColumbia-Suicide Severity Rating ScaleStructural brain alterationsLifetime suicide attemptsSeverity Rating ScaleCurrent suicidal ideationActual suicide attemptsHealthy controlsAssessment instrumentsClinical controlEarly interventionMental disordersSignificant associationFrontal poleBrain morphologySuicide riskSuicide attemptersRating ScaleYoung peopleDisordersNeuroimaging Studies of Brain Structure in Older Adults with Bipolar Disorder: A Review
Rajashekar N, Blumberg HP, Villa LM. Neuroimaging Studies of Brain Structure in Older Adults with Bipolar Disorder: A Review. Journal Of Psychiatry And Brain Science 2022, 7: e220006. PMID: 36092855, PMCID: PMC9453888, DOI: 10.20900/jpbs.20220006.Peer-Reviewed Original ResearchBipolar disorderWhite matterBrain regionsBrain differencesDiffusion-weighted magnetic resonance imaging studiesOlder adultsMagnetic resonance imaging studyMood-stabilizing medicationsWhite matter findingsGray matter reductionsLater lifeCommon mood disorderYounger age groupsResonance imaging studyStructural brain differencesSubcortical brain regionsAdverse outcomesCognitive dysfunctionBrain changesClinical dataMood disordersProtective effectElevated riskHigh riskCognitive symptomsBrain structure associated with future suicide thoughts and behaviors in female adolescents with mood disorders
Colic L, Villa L, Dauvermann M, van Velzen L, Sankar A, Goldman D, Panchal P, Kim J, Schmaal L, van Harmelen A, Blumberg H. Brain structure associated with future suicide thoughts and behaviors in female adolescents with mood disorders. Neuroscience Applied 2022, 1: 100781. DOI: 10.1016/j.nsa.2022.100781.Peer-Reviewed Original Research
2018
Preliminary examination of gray and white matter structure and longitudinal structural changes in frontal systems associated with future suicide attempts in adolescents and young adults with mood disorders
Lippard ETC, Johnston JAY, Spencer L, Quatrano S, Fan S, Sankar A, Weathers J, Pittman B, Oquendo MA, Blumberg HP. Preliminary examination of gray and white matter structure and longitudinal structural changes in frontal systems associated with future suicide attempts in adolescents and young adults with mood disorders. Journal Of Affective Disorders 2018, 245: 1139-1148. PMID: 30699858, PMCID: PMC6487887, DOI: 10.1016/j.jad.2018.11.097.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAnisotropyBipolar DisorderCross-Sectional StudiesDepressive Disorder, MajorDiffusion Tensor ImagingFemaleFrontal LobeGray MatterGyrus CinguliHumansInternal CapsuleMagnetic Resonance ImagingMaleMood DisordersPrefrontal CortexSuicidal IdeationSuicide, AttemptedWhite MatterYoung AdultConceptsMood disordersGray matter volumeLongitudinal structural changesSuicide-related behaviorsFuture suicide attemptsFractional anisotropyWhite matter structuresMatter volumeWhite matterSuicide attemptsHigh-resolution structural magnetic resonance imagingYoung adultsWhite matter fractional anisotropyMajor risk factorStructural magnetic resonance imagingCross-sectional studyFrontal white matterPrefrontal gray matter volumeMatter structuresMagnetic resonance imagingDiffusion tensor imagingInternal capsuleRisk factorsAnterior limbPrevention strategies
2006
The role of the ventral prefrontal cortex in mood disorders
Fredericks C, Kalmar J, Blumberg H. The role of the ventral prefrontal cortex in mood disorders. 2006, 545-578. DOI: 10.1093/acprof:oso/9780198565741.003.0021.Peer-Reviewed Original ResearchVentral prefrontal cortexMood disordersPrefrontal cortexPregenual anterior cingulateLateral orbitofrontal cortexRostral frontal cortexMajor depressionFrontal cortexAnterior cingulateBipolar disorderOrbitofrontal cortexBrain structuresCortexDisordersMultiple studiesSpecific subregionsNeural systemsSignificant connectivityNeuropathophysiologyCingulate