2022
Structural brain alterations associated with suicidal thoughts and behaviors in young people: results from 21 international studies from the ENIGMA Suicidal Thoughts and Behaviours consortium
van Velzen LS, Dauvermann MR, Colic L, Villa LM, Savage HS, Toenders YJ, Zhu AH, Bright JK, Campos AI, Salminen LE, Ambrogi S, Ayesa-Arriola R, Banaj N, Başgöze Z, Bauer J, Blair K, Blair RJ, Brosch K, Cheng Y, Colle R, Connolly CG, Corruble E, Couvy-Duchesne B, Crespo-Facorro B, Cullen KR, Dannlowski U, Davey CG, Dohm K, Fullerton JM, Gonul AS, Gotlib IH, Grotegerd D, Hahn T, Harrison BJ, He M, Hickie IB, Ho TC, Iorfino F, Jansen A, Jollant F, Kircher T, Klimes-Dougan B, Klug M, Leehr EJ, Lippard ETC, McLaughlin KA, Meinert S, Miller AB, Mitchell PB, Mwangi B, Nenadić I, Ojha A, Overs BJ, Pfarr JK, Piras F, Ringwald KG, Roberts G, Romer G, Sanches M, Sheridan MA, Soares JC, Spalletta G, Stein F, Teresi GI, Tordesillas-Gutiérrez D, Uyar-Demir A, van der Wee NJA, van der Werff SJ, Vermeiren RRJM, Winter A, Wu MJ, Yang TT, Thompson PM, Rentería ME, Jahanshad N, Blumberg HP, van Harmelen AL, Schmaal L. Structural brain alterations associated with suicidal thoughts and behaviors in young people: results from 21 international studies from the ENIGMA Suicidal Thoughts and Behaviours consortium. Molecular Psychiatry 2022, 27: 4550-4560. PMID: 36071108, PMCID: PMC9734039, DOI: 10.1038/s41380-022-01734-0.Peer-Reviewed Original ResearchConceptsMood disordersSuicidal thoughtsSuicide attemptsBrain alterationsMRI metricsSuicidal ideationColumbia-Suicide Severity Rating ScaleStructural brain alterationsLifetime suicide attemptsSeverity Rating ScaleCurrent suicidal ideationActual suicide attemptsHealthy controlsAssessment instrumentsClinical controlEarly interventionMental disordersSignificant associationFrontal poleBrain morphologySuicide riskSuicide attemptersRating ScaleYoung peopleDisorders
2020
What we learn about bipolar disorder from large‐scale neuroimaging: Findings and future directions from the ENIGMA Bipolar Disorder Working Group
Ching CRK, Hibar DP, Gurholt TP, Nunes A, Thomopoulos SI, Abé C, Agartz I, Brouwer RM, Cannon DM, de Zwarte S, Eyler LT, Favre P, Hajek T, Haukvik UK, Houenou J, Landén M, Lett TA, McDonald C, Nabulsi L, Patel Y, Pauling ME, Paus T, Radua J, Soeiro‐de‐Souza M, Tronchin G, van Haren N, Vieta E, Walter H, Zeng L, Alda M, Almeida J, Alnæs D, Alonso‐Lana S, Altimus C, Bauer M, Baune BT, Bearden CE, Bellani M, Benedetti F, Berk M, Bilderbeck AC, Blumberg HP, Bøen E, Bollettini I, del Mar Bonnin C, Brambilla P, Canales‐Rodríguez E, Caseras X, Dandash O, Dannlowski U, Delvecchio G, Díaz‐Zuluaga A, Dima D, Duchesnay É, Elvsåshagen T, Fears SC, Frangou S, Fullerton JM, Glahn DC, Goikolea JM, Green MJ, Grotegerd D, Gruber O, Haarman BCM, Henry C, Howells FM, Ives‐Deliperi V, Jansen A, Kircher TTJ, Knöchel C, Kramer B, Lafer B, López‐Jaramillo C, Machado‐Vieira R, MacIntosh BJ, Melloni EMT, Mitchell PB, Nenadic I, Nery F, Nugent AC, Oertel V, Ophoff RA, Ota M, Overs BJ, Pham DL, Phillips ML, Pineda‐Zapata J, Poletti S, Polosan M, Pomarol‐Clotet E, Pouchon A, Quidé Y, Rive MM, Roberts G, Ruhe HG, Salvador R, Sarró S, Satterthwaite TD, Schene AH, Sim K, Soares JC, Stäblein M, Stein DJ, Tamnes CK, Thomaidis GV, Upegui CV, Veltman DJ, Wessa M, Westlye LT, Whalley HC, Wolf DH, Wu M, Yatham LN, Zarate CA, Thompson PM, Andreassen OA, Group E. What we learn about bipolar disorder from large‐scale neuroimaging: Findings and future directions from the ENIGMA Bipolar Disorder Working Group. Human Brain Mapping 2020, 43: 56-82. PMID: 32725849, PMCID: PMC8675426, DOI: 10.1002/hbm.25098.Peer-Reviewed Original ResearchConceptsStudies of BDBipolar disorderClinical risk profileLower cortical thicknessMultimodal brain MRIFuture hypothesis-driven studiesWhite matter integrityWorking GroupCommon medicationsPathophysiological mechanismsEnhancing Neuro Imaging GeneticsBrain alterationsBrain MRICortical thicknessSubcortical volumesSymptom patternsMental illnessRisk profileBrain measuresGroup studyHypothesis-driven studiesConsensus findingsPool dataBrain variationMRI
2019
Imaging suicidal thoughts and behaviors: a comprehensive review of 2 decades of neuroimaging studies
Schmaal L, van Harmelen AL, Chatzi V, Lippard ETC, Toenders YJ, Averill LA, Mazure CM, Blumberg HP. Imaging suicidal thoughts and behaviors: a comprehensive review of 2 decades of neuroimaging studies. Molecular Psychiatry 2019, 25: 408-427. PMID: 31787757, PMCID: PMC6974434, DOI: 10.1038/s41380-019-0587-x.Peer-Reviewed Original ResearchConceptsVentral prefrontal cortexSuicidal ideationSuicidal thoughtsDorsal PFCDorsal anterior cingulate cortexAnterior cingulate cortexHigh-risk circumstancesBrain alterationsBrain areasLarger sample sizeCingulate cortexMolecular alterationsMental disordersNarrative reviewSuicide thoughtsPrefrontal cortexNeurobiological substratesInhibition of behaviorSuicide attempt behaviorBrain systemsCortexInsulaImpairmentComprehensive reviewLongitudinal design