2024
Towards a neurodevelopmental model of bipolar disorder: a critical review of trait- and state-related functional neuroimaging in adolescents and young adults
Colic L, Sankar A, Goldman D, Kim J, Blumberg H. Towards a neurodevelopmental model of bipolar disorder: a critical review of trait- and state-related functional neuroimaging in adolescents and young adults. Molecular Psychiatry 2024, 1-13. PMID: 39333385, DOI: 10.1038/s41380-024-02758-4.Peer-Reviewed Original ResearchFunctional magnetic resonance imagingVentral prefrontal cortexBipolar disorderPrefrontal cortexNeurodevelopmental modelBrain systemsMood statesFunctional magnetic resonance imaging studyModel of bipolar disorderProcessing of rewardAcute mood statesRegulation of emotionVentral cortical regionsYoung adultsFunctional imaging findingsTrait vulnerabilityMood episodesSyndromal BDNeuroimaging evidenceFunctional neuroanatomyBrain differencesNeuroimaging studiesNeurodevelopmental mechanismsPrecentral gyrusBrain regionsDeficits in prefrontal metabotropic glutamate receptor 5 are associated with functional alterations during emotional processing in bipolar disorder
Asch R, Worhunsky P, Davis M, Holmes S, Cool R, Boster S, Carson R, Blumberg H, Esterlis I. Deficits in prefrontal metabotropic glutamate receptor 5 are associated with functional alterations during emotional processing in bipolar disorder. Journal Of Affective Disorders 2024, 361: 415-424. PMID: 38876317, PMCID: PMC11250898, DOI: 10.1016/j.jad.2024.06.025.Peer-Reviewed Original ResearchMetabotropic glutamate receptor 5Bipolar disorderGlutamate receptor 5Positron emission tomographyFear processingEmotional processingAssociated with greater activationEmotion processing taskAssociated with impulsivityFunctional brain differencesAssociated with functional alterationsParietal brain regionsPathology of BDIncreased cortical activityAssociated with difficultiesDepressive disorderHealthy comparisonReceptor availabilityBrain differencesPre/postcentral gyriAttention difficultiesGreater activationBrain regionsPsychomotor functionTreatment developmentBipolar symptoms, somatic burden and functioning in older‐age bipolar disorder: A replication study from the global aging & geriatric experiments in bipolar disorder database (GAGE‐BD) project
Sajatovic M, Rej S, Almeida O, Altinbas K, Balanzá‐Martínez V, Barbosa I, Beunders A, Blumberg H, Briggs F, Dols A, Forester B, Forlenza O, Gildengers A, Jimenez E, Klaus F, Lafer B, Mulsant B, Mwangi B, Nunes P, Olagunju A, Oluwaniyi S, Orhan M, Patrick R, Radua J, Rajji T, Sarna K, Schouws S, Simhandl C, Sekhon H, Soares J, Sutherland A, Teixeira A, Tsai S, Vidal‐Rubio S, Vieta E, Yala J, Eyler L. Bipolar symptoms, somatic burden and functioning in older‐age bipolar disorder: A replication study from the global aging & geriatric experiments in bipolar disorder database (GAGE‐BD) project. International Journal Of Geriatric Psychiatry 2024, 39: e6057. PMID: 38511929, DOI: 10.1002/gps.6057.Peer-Reviewed Original ResearchConceptsOlder age bipolar disorderBipolar Disorder DatabaseSomatic burdenBipolar disorderGAGE-BDAssociated with worse functionSymptom severityBD symptomsAssociated with depression severityOlder-age bipolar disorderGlobal Aging & Geriatric ExperimentsManic symptom severityAssociated with poorer functioningGeriatric experiencesAssociation of depressionBipolar symptomsSevere maniaDepression severityDepressive symptomsLow functioningSomatic conditionsPoor functionWorse functionArchival datasetWave 2Sociodemographic and clinical characteristics of people with oldest older age bipolar disorder in a global sample: Results from the global aging and geriatric experiments in bipolar disorder project
Chen P, Sajatovic M, Briggs F, Mulsant B, Dols A, Gildengers A, Yala J, Beunders A, Blumberg H, Rej S, Forlenza O, Jimenez E, Schouws S, Orhan M, Sutherland A, Vieta E, Tsai S, Sarna K, Eyler L, Investigators T. Sociodemographic and clinical characteristics of people with oldest older age bipolar disorder in a global sample: Results from the global aging and geriatric experiments in bipolar disorder project. International Journal Of Geriatric Psychiatry 2024, 39: e6073. PMID: 38393311, DOI: 10.1002/gps.6073.Peer-Reviewed Original ResearchConceptsOlder age bipolar disorderBipolar disorderGAGE-BDSeverity of manic symptomsRates of suicidal thoughtsLower depressive symptomsComorbid physical conditionsClinical characteristics of peopleGeriatric experiencesManic symptomsClinical characteristicsDepressive symptomsSuicidal thoughtsCharacteristics of peoplePhysical burdenDisordersGlobal ageMedical burdenAge categoriesLogistic regression modelsMultinomial logistic regression modelCross-sectional analysisYounger groupMusculoskeletal domainsSymptomsBlood epigenome-wide association studies of suicide attempt in adults with bipolar disorder
Mirza S, Lima C, Del Favero-Campbell A, Rubinstein A, Topolski N, Cabrera-Mendoza B, Kovács E, Blumberg H, Richards J, Williams A, Wemmie J, Magnotta V, Fiedorowicz J, Gaine M, Walss-Bass C, Quevedo J, Soares J, Fries G. Blood epigenome-wide association studies of suicide attempt in adults with bipolar disorder. Translational Psychiatry 2024, 14: 70. PMID: 38296944, PMCID: PMC10831084, DOI: 10.1038/s41398-024-02760-y.Peer-Reviewed Original ResearchConceptsEpigenome-wide association studiesDifferentially methylated regionsDifferentially methylated positionsAssociation studiesCo-methylation network analysisBipolar disorderDNA methylation patternsSuicide attemptsReplication cohortHistory of SAGene ontology analysisSignificant CpG sitesMethylation patternsDNA methylationCpG sitesOntology analysisImmune-related genesEnrichment analysisNon-psychiatric controlsCalcium signalingGenesDNAClinical interviewSA historyNetwork analysisPreliminary Study of White Matter Abnormalities and Associations With the Metabotropic Glutamate Receptor 5 to Distinguish Bipolar and Major Depressive Disorders
Fan S, Asch R, Davis M, DellaGioia N, Cool R, Blumberg H, Esterlis I. Preliminary Study of White Matter Abnormalities and Associations With the Metabotropic Glutamate Receptor 5 to Distinguish Bipolar and Major Depressive Disorders. Chronic Stress 2024, 8: 24705470231225320. PMID: 38250007, PMCID: PMC10798116, DOI: 10.1177/24705470231225320.Peer-Reviewed Original ResearchMetabotropic glutamate receptor 5Bipolar disorderGlutamate receptor 5UF FAUncinate fasciculusFractional anisotropyWhole-brain analysisMultimodal neuroimaging approachDifferentiation of BDDiffusion-weighted MRI scansFrontotemporal dysconnectivityFrontotemporal systemFunctional dysconnectivityDepressive disorderNeurobiological mechanismsMGluR5 levelsWhite matterWhite matter abnormalitiesNeuroimaging approachesWM integrityNeural mechanismsMDDWhole-brainWM abnormalitiesReceptor 5
2023
Sex Differences Among Older Adults With Bipolar Disorder: Results From the Global Aging & Geriatric Experiments in Bipolar Disorder (GAGE-BD) Project
Blanken M, Oudega M, Almeida O, Schouws S, Orhan M, Beunders A, Klumpers U, Sonnenberg C, Blumberg H, Eyler L, Forester B, Forlenza O, Gildengers A, Mulsant B, Rajji T, Rej S, Sarna K, Sutherland A, Yala J, Vieta E, Tsai S, Briggs F, Sajatovic M, Dols A. Sex Differences Among Older Adults With Bipolar Disorder: Results From the Global Aging & Geriatric Experiments in Bipolar Disorder (GAGE-BD) Project. American Journal Of Geriatric Psychiatry 2023, 32: 326-338. PMID: 37981507, DOI: 10.1016/j.jagp.2023.10.008.Peer-Reviewed Original ResearchOlder age bipolar disorderBipolar disorderPsychiatric hospitalizationMood symptomsSex differencesClinical sex differencesMore psychiatric hospitalizationsPhysical health comorbiditiesLifetime psychiatric comorbidityGlobal AGEingBipolar Disorder (STEP-BD) studySex-specific researchAdult bipolar disorderSubstance abuse disordersDepressive mood symptomsOld age womenClinical characteristicsHealth comorbiditiesSevere courseClinical presentationStudy cohortMale sexPsychiatric comorbidityFemale sexAge womenPredictors of Functional Impairment in Bipolar Disorder: Results From 13 Cohorts From Seven Countries by the Global Bipolar Cohort Collaborative
Burdick K, Millett C, Yocum A, Altimus C, Andreassen O, Aubin V, Belzeaux R, Berk M, Biernacka J, Blumberg H, Cleare A, Diaz-Byrd C, Dubertret C, Etain B, Eyler L, Forester B, Fullerton J, Frye M, Gard S, Godin O, Haffen E, Klaus F, Lagerberg T, Leboyer M, Martinez-Aran A, McElroy S, Mitchell P, Olie E, Olorunfemi P, Passerieux C, Peters A, Pham D, Polosan M, Potter J, Sajatovic M, Samalin L, Schwan R, Shanahan M, Solé B, Strawbridge R, Stuart A, Torres I, Ueland T, Vieta E, Williams L, Wrobel A, Yatham L, Young A, Nierenberg A, McInnis M. Predictors of Functional Impairment in Bipolar Disorder: Results From 13 Cohorts From Seven Countries by the Global Bipolar Cohort Collaborative. FOCUS The Journal Of Lifelong Learning In Psychiatry 2023, 21: 444-452. PMID: 38694997, PMCID: PMC11058953, DOI: 10.1176/appi.focus.23021021.Peer-Reviewed Original ResearchBipolar disorderFunctional impairmentComplete recoveryComorbid substance use disorderPersistent functional impairmentPatient's complete recoveryLogistic regression analysisPrior mood episodesProspective longitudinal studySubstance use disordersPsychotropic medicationsHeterogeneous presentationMood episodesClinical research communityDepressive symptomsOptimizing outcomesUse disordersCohortLower functioningLongitudinal studyRegression analysisGreater total numberHigh rateMultiple cohortsImpairmentEssential data dimensions for prospective international data collection in older age bipolar disorder (OABD): Recommendations from the GAGE‐BD group
Lavin P, Rej S, Olagunju A, Teixeira A, Dols A, Alda M, Almeida O, Altinbas K, Balanzá‐Martínez V, Barbosa I, Blumberg H, Briggs F, Calkin C, Cassidy K, Forester B, Forlenza O, Hajek T, Haarman B, Jimenez E, Lafer B, Mulsant B, Oluwaniyi S, Patrick R, Radua J, Schouws S, Sekhon H, Simhandl C, Soares J, Tsai S, Vieta E, Villa L, Sajatovic M, Eyler L. Essential data dimensions for prospective international data collection in older age bipolar disorder (OABD): Recommendations from the GAGE‐BD group. Bipolar Disorders 2023, 25: 554-563. PMID: 36843436, DOI: 10.1111/bdi.13312.Peer-Reviewed Original ResearchConceptsOlder age bipolar disorderBipolar disorderGeneral medical comorbidityGeriatric mental healthSubgroup of patientsInternational data collectionSubjective cognitive functionMedical comorbiditiesCurrent medicationsPsychiatric comorbidityFamily historyDelphi consensusPsychotic symptomsBD diagnosisClinical practiceSystematic reviewCognitive functionCore symptomsMental healthGlobal AGEingComorbiditiesDisordersSymptomsInitial recommendationsData collectionPredicting depressed and elevated mood symptomatology in bipolar disorder using brain functional connectomes
Sankar A, Shen X, Colic L, Goldman D, Villa L, Kim J, Pittman B, Scheinost D, Constable R, Blumberg H. Predicting depressed and elevated mood symptomatology in bipolar disorder using brain functional connectomes. Psychological Medicine 2023, 53: 6656-6665. PMID: 36891769, PMCID: PMC10491744, DOI: 10.1017/s003329172300003x.Peer-Reviewed Original ResearchBipolar disorderYoung Mania Rating ScaleMania Rating ScaleFunctional connectomeBrain functional connectomeSymptom scoresHamilton DepressionMagnetic resonance imaging dataEmotion processing taskMood symptomatologyRating ScaleFunctional magnetic resonance imaging (fMRI) dataConnectomeAdultsImaging dataIndependent samplesPredictive abilitySymptomatology
2022
Aging of the brain in bipolar disorder: Illness- and onset-related effects in cortical thickness and subcortical gray matter volume
Villa L, Colic L, Kim J, Sankar A, Goldman D, Lessing B, Pittman B, Alexopoulos G, van Dyck C, Blumberg H. Aging of the brain in bipolar disorder: Illness- and onset-related effects in cortical thickness and subcortical gray matter volume. Journal Of Affective Disorders 2022, 323: 875-883. PMID: 36526112, PMCID: PMC9839524, DOI: 10.1016/j.jad.2022.12.026.Peer-Reviewed Original ResearchConceptsGray matter volumeOccipital cortical thicknessSubcortical gray matter volumesCortical thicknessBipolar disorderMatter volumeOlder adultsOnset of BDIndividuals age 40Striatal gray matter volumeGray matter reductionsOnset bipolar disorderGray matter decreasesPrefrontal cortical thicknessStructural brain differencesHigh suicide riskCross-sectional designHealthy controlsCognitive dysfunctionTreatment resistanceAge 40Striatal volumeSevere symptomsSuicide attempt historySuicide attemptsDifferences in Quantification of the Metabotropic Glutamate Receptor 5 Across Bipolar Disorder and Major Depressive Disorder
Holmes S, Asch R, Davis M, DellaGioia N, Pashankar N, Gallezot J, Nabulsi N, Matuskey D, Sanacora G, Carson R, Blumberg H, Esterlis I. Differences in Quantification of the Metabotropic Glutamate Receptor 5 Across Bipolar Disorder and Major Depressive Disorder. Biological Psychiatry 2022, 93: 1099-1107. PMID: 36764853, PMCID: PMC10164841, DOI: 10.1016/j.biopsych.2022.10.018.Peer-Reviewed Original ResearchConceptsMajor depressive disorderMetabotropic glutamate receptor 5Glutamate receptor 5MGluR5 availabilityBipolar disorderPositron emission tomographyHC groupDepressive disorderReceptor 5Emission tomographyHealthy control individualsPossible treatment targetsGlutamate transmissionBD depressionTreatment strategiesBD groupMGluR5Depressive symptomsNovel treatmentsCognitive alterationsTreatment targetsSynaptic plasticityControl individualsAccurate diagnosisSignificant negative correlationClinical correlates of late‐onset versus early‐onset bipolar disorder in a global sample of older adults
Lavin P, Buck G, Almeida O, Su C, Eyler L, Dols A, Blumberg H, Forester B, Forlenza O, Gildengers A, Mulsant B, Tsai S, Vieta E, Schouws S, Briggs F, Sutherland A, Sarna K, Yala J, Orhan M, Korten N, Sajatovic M, Rej S, Investigators G. Clinical correlates of late‐onset versus early‐onset bipolar disorder in a global sample of older adults. International Journal Of Geriatric Psychiatry 2022, 37 PMID: 36317317, DOI: 10.1002/gps.5833.Peer-Reviewed Original ResearchA graph theory neuroimaging approach to distinguish the depression of bipolar disorder from major depressive disorder in adolescents and young adults
Goldman DA, Sankar A, Rich A, Kim JA, Pittman B, Constable RT, Scheinost D, Blumberg HP. A graph theory neuroimaging approach to distinguish the depression of bipolar disorder from major depressive disorder in adolescents and young adults. Journal Of Affective Disorders 2022, 319: 15-26. PMID: 36103935, PMCID: PMC9669784, DOI: 10.1016/j.jad.2022.09.016.Peer-Reviewed Original ResearchConceptsAdolescents/young adultsMajor depressive disorderDepressive disorderYoung adultsICD increasesBipolar disorderInterhemispheric functional connectivityFunctional connectivity differencesSeed-based analysisFunctional connectivity patternsSeed-based connectivityFunctional magnetic resonanceFunctional connectivity measuresBasal gangliaFunctional dysconnectivityIllness progressionTreatment strategiesClinical measuresEarly diagnosisHC groupTargeted treatmentConnectivity differencesSuicide thoughtsFunctional connectivityDeleterious treatmentGender-related association among childhood maltreatment, brain structure and clinical features in bipolar disorder
Colic L, Clark A, Sankar A, Rathi DJ, Goldman DA, Kim JA, Villa LM, Edmiston EK, Lippard ETC, Pittman B, Constable RT, Mazure CM, Blumberg HP. Gender-related association among childhood maltreatment, brain structure and clinical features in bipolar disorder. European Neuropsychopharmacology 2022, 63: 35-46. PMID: 36037590, PMCID: PMC9593266, DOI: 10.1016/j.euroneuro.2022.07.186.Peer-Reviewed Original ResearchConceptsClinical featuresBipolar disorderCM severityChildhood maltreatmentLeft hippocampusPost-traumatic stress disorder (PTSD) comorbidityBrain structuresStructural magnetic resonance imagingGender-related associationMagnetic resonance imagingGray matter structuresChildhood Trauma QuestionnaireGender-related differencesCM exposureHealthy controlsClinical assessmentDisorder comorbidityMood symptomsPathophysiological modelGender-related effectsResonance imagingHippocampusFrontal poleTrauma QuestionnaireSeverityDemographic and clinical characteristics of lithium‐treated older adults with bipolar disorder
Forlenza OV, Hajek T, Almeida OP, Beunders AJM, Blumberg HP, Briggs FBS, De‐Paula V, Dols A, Eyler LT, Forester BP, Gildengers A, Jimenez E, Korten NCM, Lafer B, McWhinney SR, Mulsant B, Rej S, Sarna K, Schouws S, Sutherland A, Tsai S, Vieta E, Yala J, Sajatovic M, initiative G. Demographic and clinical characteristics of lithium‐treated older adults with bipolar disorder. Acta Psychiatrica Scandinavica 2022, 146: 442-455. PMID: 35837985, PMCID: PMC9588573, DOI: 10.1111/acps.13474.Peer-Reviewed Original ResearchConceptsLithium usersBipolar disorderClinical characteristicsOlder adultsDepression Rating ScaleCross-sectional analysisGlobal cognitive stateCardiovascular comorbiditiesCross-sectional approachClinical profileMood stabilizersLithium therapySevere depressionPsychiatric diagnosisRating ScaleCurrent prescriptionGlobal AGEingDisordersRapid cyclingAdultsRelevant differencesSafety concernsLower scoresCurrent useMethodological limitationsDemographic and Clinical Characteristics of Antipsychotic Drug-Treated Older Adults with Bipolar Disorder from the Global Aging & Geriatric Experiments in Bipolar Disorder Database (GAGE-BD).
Chen P, Eyler LT, Gildengers A, Beunders AJ, Blumberg HP, Briggs FB, Dols A, Rej S, Forlenza OV, Jimenez E, Mulsant B, Schouws S, Orhan M, Sarna K, Sutherland AN, Vieta E, Tsai S, Yala J, Villa LM, Sajatovic M. Demographic and Clinical Characteristics of Antipsychotic Drug-Treated Older Adults with Bipolar Disorder from the Global Aging & Geriatric Experiments in Bipolar Disorder Database (GAGE-BD). Psychopharmacology Bulletin 2022, 52: 8-33. PMID: 35721813, PMCID: PMC9172555.Peer-Reviewed Original ResearchConceptsOlder age bipolar disorderFirst-generation antipsychoticsAntipsychotic drugsBipolar disorderPsychiatric hospitalizationMean age 63.2 yearsGlobal AGEingClinical characteristicsFrequent hospitalizationsClinical variablesSevere illnessTreatment statusGreater burdenHospitalizationDisorder databaseOlder adultsCross-sectional dataLongitudinal outcomesDisordersPatientsGeneralized mixed modelMultivariate model resultsInternational studiesDrugsObservational analysisToward a Digital Future in Bipolar Disorder Assessment: A Systematic Review of Disruptions in the Rest-Activity Cycle as Measured by Actigraphy
Panchal P, de Queiroz Campos G, Goldman DA, Auerbach RP, Merikangas KR, Swartz HA, Sankar A, Blumberg HP. Toward a Digital Future in Bipolar Disorder Assessment: A Systematic Review of Disruptions in the Rest-Activity Cycle as Measured by Actigraphy. Frontiers In Psychiatry 2022, 13: 780726. PMID: 35677875, PMCID: PMC9167949, DOI: 10.3389/fpsyt.2022.780726.Peer-Reviewed Original ResearchRest-activity patternsBipolar disorderSystematic reviewDepressive episodeActigraphy measuresMore adverse outcomesLonger sleep onset latencyComprehensive systematic reviewDaily activitiesCurrent systematic reviewSleep onset latencyUse of actigraphyRest-activity cycleActivity patternsSpecific phenotypic markersTherapeutic optionsAdverse outcomesEmbase databasesManic symptomsPRISMA guidelinesPrevention optionsOnset latencyPredictive valueCognitive impairmentOverall daily activityA Multimodal Imaging Approach to Identify Brain Connectivity Targets for Early Detection, and to Reduce Symptoms and Prevent Progression and Suicide Risk, in Bipolar Disorder
Goldman D, Sankar A, Colic L, Villa L, Kim J, Pittman B, Constable R, Scheinost D, Blumberg H. A Multimodal Imaging Approach to Identify Brain Connectivity Targets for Early Detection, and to Reduce Symptoms and Prevent Progression and Suicide Risk, in Bipolar Disorder. Biological Psychiatry 2022, 91: s38-s39. DOI: 10.1016/j.biopsych.2022.02.114.Peer-Reviewed Original ResearchPredictors of functional impairment in bipolar disorder: Results from 13 cohorts from seven countries by the global bipolar cohort collaborative
Burdick KE, Millett CE, Yocum AK, Altimus CM, Andreassen OA, Aubin V, Belzeaux R, Berk M, Biernacka JM, Blumberg H, Cleare AJ, Diaz‐Byrd C, Dubertret C, Etain B, Eyler LT, Forester BP, Fullerton JM, Frye MA, Gard S, Godin O, Haffen E, Klaus F, Lagerberg TV, Leboyer M, Martinez‐Aran A, McElroy S, Mitchell PB, Olie E, Olorunfemi P, Passerieux C, Peters AT, Pham DL, Polosan M, Potter JR, Sajatovic M, Samalin L, Schwan R, Shanahan M, Solé B, Strawbridge R, Stuart AL, Torres I, Ueland T, Vieta E, Williams LJ, Wrobel AL, Yatham LN, Young AH, Nierenberg AA, McInnis MG. Predictors of functional impairment in bipolar disorder: Results from 13 cohorts from seven countries by the global bipolar cohort collaborative. Bipolar Disorders 2022, 24: 709-719. PMID: 35322518, PMCID: PMC9500115, DOI: 10.1111/bdi.13208.Peer-Reviewed Original ResearchConceptsBipolar disorderFunctional impairmentComplete recoveryComorbid substance use disorderPersistent functional impairmentPatient's complete recoveryPrior mood episodesLogistic regression analysisProspective longitudinal studySubstance use disordersPsychotropic medicationsHeterogeneous presentationBipolar cohortMood episodesClinical research communityDepressive symptomsOptimizing outcomesUse disordersCohortLower functioningImpairmentLongitudinal studyDisordersRegression analysisGreater total number