2004
Utility of in vitro tests in predicting the in vivo viability of stored PLTs
Murphy S, Rinder H, Smith B. Utility of in vitro tests in predicting the in vivo viability of stored PLTs. Transfusion 2004, 44: 618-619. PMID: 15043581, DOI: 10.1111/j.1537-2995.2004.00355.x.Peer-Reviewed Original Research
2001
Xenotransplantation of immunodeficient mice with mobilized human blood CD34+ cells provides an in vivo model for human megakaryocytopoiesis and platelet production
Perez L, Rinder H, Wang C, Tracey J, Maun N, Krause D. Xenotransplantation of immunodeficient mice with mobilized human blood CD34+ cells provides an in vivo model for human megakaryocytopoiesis and platelet production. Blood 2001, 97: 1635-1643. PMID: 11238102, DOI: 10.1182/blood.v97.6.1635.Peer-Reviewed Original ResearchConceptsPeripheral blood stem cellsHuman peripheral blood stem cellsPlatelet productionVivo modelStudy of megakaryocytopoiesisCFU-MKHuman megakaryocytopoiesisImmunodeficient miceBone marrowHuman plateletsExogenous cytokinesNOD/SCID miceHuman hematopoiesisBlood stem cellsHuman cell engraftmentPlatelet developmentNonobese diabetic/Lymphoid lineageStem cellsHuman blood CD34MegakaryocytopoiesisPeripheral bloodCytokine stimulationMurine recipientsThrombin stimulation
1999
Role of C3 Cleavage in Monocyte Activation During Extracorporeal Circulation
Rinder C, Rinder H, Johnson K, Smith M, Lee D, Tracey J, Polack G, Higgins P, Yeh C, Smith MD B. Role of C3 Cleavage in Monocyte Activation During Extracorporeal Circulation. Circulation 1999, 100: 553-558. PMID: 10430771, DOI: 10.1161/01.cir.100.5.553.Peer-Reviewed Original ResearchConceptsMonocyte activationC5b-9CD11b upregulationComplement inhibitionExtracorporeal circulationPlatelet activationTerminal complement inhibitionMonocyte-platelet conjugatesComplement regulatory protein CD46Early complement componentsPMN elastase releaseGeneration of C3aMicrograms/mLCardiopulmonary bypassBlood cell activationPMN activationElastase releaseCell activationHuman volunteersMicrograms/Complement activationPrevents plateletComplement componentsWhole bloodCommon pathway
1998
Platelet activation and its detection during the preparation of platelets for transfusion
Rinder H, Ault K. Platelet activation and its detection during the preparation of platelets for transfusion. Transfusion Medicine Reviews 1998, 12: 271-287. PMID: 9798270, DOI: 10.1016/s0887-7963(98)80003-5.Peer-Reviewed Original ResearchCorrelation of Thrombosis With Increased Platelet Turnover in Thrombocytosis
Rinder H, Schuster J, Rinder C, Wang C, Schweidler H, Smith B. Correlation of Thrombosis With Increased Platelet Turnover in Thrombocytosis. Blood 1998, 91: 1288-1294. PMID: 9454759, DOI: 10.1182/blood.v91.4.1288.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overBlood PlateletsFemaleHumansMaleMiddle AgedRisk FactorsThrombocytosisThrombosisConceptsRP countsNormal platelet countPlatelet countThrombocytosis patientsPlatelet turnoverHealthy controlsART patientsTreatment responsePrimary myeloproliferative disordersElevated platelet countSymptoms of thrombosisAspirin therapyRecurrent thrombosisThrombotic complicationsAspirin treatmentArterial thrombosisDVT patientsThrombotic riskTransient thrombocytosisThrombosis riskDeep veinsSecondary thrombocytosisAbsolute countsMyeloproliferative disordersThrombosisPlatelet function testing by flow cytometry.
Rinder H. Platelet function testing by flow cytometry. Clinical Laboratory Science 1998, 11: 365-72. PMID: 10345505.Peer-Reviewed Original ResearchConceptsFlow cytometryPlatelet functionEx vivo platelet functionVivo platelet functionPlatelet function testingIntracellular calcium fluxExposure of plateletsPlatelet glycoprotein receptorsFluorescent monoclonal antibodiesFunction testingPlatelet aggregationActivation statusCalcium fluxMonoclonal antibodiesMicroparticle generationCytometryGranule contentsCytometric methodologyPlateletsGlycoprotein receptorsSecretionAntibodiesReceptors
1996
Characterization of the P-selectin ligand on human hematopoietic progenitors.
Tracey J, Rinder H. Characterization of the P-selectin ligand on human hematopoietic progenitors. Experimental Hematology 1996, 24: 1494-500. PMID: 8950232.Peer-Reviewed Original ResearchConceptsP-selectin glycoprotein ligand-1P-selectinMature neutrophilsPlatelet P-selectinTreatment of CD34Surface of CD34PSGL-1 expressionPreincubation of CD34Platelet adhesionTransplanted stem cellsP-selectin ligandsControl epitopesKG1a cell lineCD34MoAbMonoclonal antibodiesProgenitor cellsCD34 moleculeHuman hematopoietic progenitorsChelation of calciumPhorbol ester treatmentLigand 1Platelet bindingCell linesEpitopesReticulated platelet values in normal and thrombocytopenic neonates
Peterec S, Brennan S, Rinder H, Wnek J, Beardsley D. Reticulated platelet values in normal and thrombocytopenic neonates. The Journal Of Pediatrics 1996, 129: 269-274. PMID: 8765626, DOI: 10.1016/s0022-3476(96)70253-6.Peer-Reviewed Original ResearchConceptsWeeks of gestationRP percentagePlatelet destructionPercentage of RPImmune thrombocytopeniaTerm neonatesImmune platelet destructionGestational age groupsPlatelet productionRP countsPreterm neonatesThrombocytopenic neonatesNeonatal thrombocytopeniaOld neonatePlatelet valuesThrombocytopeniaNeonatesHealthy adultsAge groupsRibonucleic acid contentWeeksPreliminary dataGestationBirthAdults
1995
Nitroprusside Inhibition of Platelet Function Is Transient and Reversible by Catecholamine Priming
Harris S, Rinder C, Rinder H, Tracey J, Smith B, Hines R. Nitroprusside Inhibition of Platelet Function Is Transient and Reversible by Catecholamine Priming. Anesthesiology 1995, 83: 1145-1152.. PMID: 8533905, DOI: 10.1097/00000542-199512000-00003.Peer-Reviewed Original ResearchConceptsAlpha-granule releaseSodium nitroprusside infusionSodium nitroprussidePlatelet functionNitroprusside infusionPlatelet aggregationSodium nitroprusside administrationP-selectin expressionPlatelet-rich plasmaMeasures of plateletIntravenous crystalloidImpaired coagulationNitroprusside administrationAntiplatelet effectEpinephrine pretreatmentNormal volunteersVivo findingsHuman volunteersNitroprussideVivo inhibitionVitro inhibitionInhibitory effectSignificant inhibitionRapid reversibilityTime course
1993
Determination of the percentage of thiazole orange (TO)‐positive, “reticulated” platelets using autologous erythrocyte TO fluorescence as an internal standard
Bonan J, Rinder H, Smith B. Determination of the percentage of thiazole orange (TO)‐positive, “reticulated” platelets using autologous erythrocyte TO fluorescence as an internal standard. Cytometry 1993, 14: 690-694. PMID: 8404376, DOI: 10.1002/cyto.990140615.Peer-Reviewed Original ResearchAspirin Does Not Inhibit Adenosine Diphosphate-Induced Platelet α-Granule Release
Rinder C, Student L, Bonan J, Rinder H, Smith B. Aspirin Does Not Inhibit Adenosine Diphosphate-Induced Platelet α-Granule Release. Blood 1993, 82: 505-512. PMID: 7687162, DOI: 10.1182/blood.v82.2.505.505.Peer-Reviewed Original ResearchConceptsP-selectin expressionAlpha-granule secretionPlatelet alpha-granule secretionAspirin treatmentP-selectinGranule secretionPlatelet alpha-granule releaseArachidonic acidCyclooxygenase-dependent metabolitesPlatelet surface expressionPlatelet α-granule releasePlatelet dense granule secretionAlpha-granule releaseΑ-granule releaseDense granule secretionPolymorphonuclear lymphocytesAmiloride treatmentLipoxygenase inhibitorsAspirinSecretionWhole bloodPlatelet-platelet interactionsTreatmentInvolvement of metabolitesPlatelets
1992
The Significance of Platelets with Increased RNA Content (Reticulated Platelets) A Measure of the Rate of Thrombopoiesis
Ault K, Rinder H, Mitchell J, Carmody M, Vary C, Hillman R. The Significance of Platelets with Increased RNA Content (Reticulated Platelets) A Measure of the Rate of Thrombopoiesis. American Journal Of Clinical Pathology 1992, 98: 637-646. PMID: 1281383, DOI: 10.1093/ajcp/98.6.637.Peer-Reviewed Original ResearchConceptsPlatelet-associated immunoglobulinsRate of thrombopoiesisThrombocytopenic patientsAbsolute numberSignificance of plateletsSubset of patientsNucleic acid contentAnti-platelet antiserumStudies of micePeripheral destructionPlatelet countReticulocyte responseSubnormal levelsNormal rangePatientsAverage absolute numberFlow cytometric measurementsThrombopoietic responseNormal levelsPlatelet increaseElevated levelsFluorescent dye thiazole orangeImmunoglobulinPlateletsCytometric measurementsCardiopulmonary Bypass Induces Leukocyte-Platelet Adhesion
Rinder C, Bonan J, Rinder H, Mathew J, Hines R, Smith B. Cardiopulmonary Bypass Induces Leukocyte-Platelet Adhesion. Blood 1992, 79: 1201-1205. PMID: 1371416, DOI: 10.1182/blood.v79.5.1201.1201.Peer-Reviewed Original ResearchConceptsLeukocyte-platelet conjugatesCardiopulmonary bypassMonocyte-platelet conjugatesEnd of CPBStart of CPBActivation of monocytesAlpha-granule releaseGMP-140 expressionGranule membrane protein-140Time courseLeukocyte-platelet adhesionCD11b expressionMonocyte activationSurface CD11bWhole bloodGMP-140Surface expressionProtein 140Increased numberCD11bBypassMonocytesPlateletsPlatelet adhesionConjugatesActivation of platelet concentrate during preparation and storage.
Rinder H, Snyder E. Activation of platelet concentrate during preparation and storage. Blood Cells Molecules And Diseases 1992, 18: 445-56; discussion 457-60. PMID: 1283703.Peer-Reviewed Original Research
1991
Progressive platelet activation with storage: evidence for shortened survival of activated platelets after transfusion
Rinder H, Murphy M, Mitchell J, Stocks J, Ault K, Hillman R. Progressive platelet activation with storage: evidence for shortened survival of activated platelets after transfusion. Transfusion 1991, 31: 409-414. PMID: 1710840, DOI: 10.1046/j.1537-2995.1991.31591263195.x.Peer-Reviewed Original ResearchConceptsPercentage of plateletsPlatelet activationNormal subjectsProgressive platelet activationThrombocytopenic cancer patientsPlatelet concentrate transfusionAlpha-granule membrane protein-140Significant platelet activationConcentrate transfusionPlatelet incrementCancer patientsPlatelet recoveryThrombocytopenic patientsAutologous plateletsPosttransfusion recoveryFlow cytometryStandard blood bank conditionsGMP-140Protein 140PlateletsTransfusionPlatelet surfacePatientsSuch activationDay of collection
1990
In Vitro and In Vivo Evaluation of Platelet Transfusions Administered Through an Electromechanical Infusion Pump
Snyder E, Rinder H, Napychank P. In Vitro and In Vivo Evaluation of Platelet Transfusions Administered Through an Electromechanical Infusion Pump. American Journal Of Clinical Pathology 1990, 94: 77-80. PMID: 2360566, DOI: 10.1093/ajcp/94.1.77.Peer-Reviewed Original ResearchConceptsPlatelet transfusionsInfusion pumpGravity infusionPlatelet concentratesVivo platelet recoveryBeta-thromboglobulin releaseAdult patientsOncology patientsClinical benefitThrombocytopenic patientsPlatelet recoveryTransfusion reactionsCount incrementCell countPatientsInfusion pump systemPlatelet damageInfusion systemVivo evaluationTransfusionSignificant differencesLDH dischargeMorphology scoreInfusionHours
1989
Correlated measurement of platelet release and aggregation in whole blood
Ault K, Rinder H, Mitchell J, Rinder C, Lambrew C, Hillman R. Correlated measurement of platelet release and aggregation in whole blood. Cytometry 1989, 10: 448-455. PMID: 2475308, DOI: 10.1002/cyto.990100413.Peer-Reviewed Original Research