1993
Inhibition of nitric oxide synthase increases extracellular cerebral glutamate concentration after global ischemia
Zhang J, Benveniste H, Piantadosi C. Inhibition of nitric oxide synthase increases extracellular cerebral glutamate concentration after global ischemia. Neuroscience Letters 1993, 157: 179-182. PMID: 7694195, DOI: 10.1016/0304-3940(93)90731-y.Peer-Reviewed Original ResearchConceptsGlutamate releaseGlutamate concentrationNitric oxide synthase inhibitionCerebral glutamate concentrationsOxide synthase inhibitionGlobal brain ischemiaInhibition of NOSNitric oxide synthaseExtracellular glutamate releaseCerebral microdialysisBrain ischemiaForebrain ischemiaControl ratsGlobal ischemiaNOS inhibitorOxide synthaseSynthase inhibitionCarotid arteryBrain flowDialysis probeIschemiaDialysate concentrationsControl valuesRatsReperfusion
1992
Mechanism of detection of acute cerebral ischemia in rats by diffusion-weighted magnetic resonance microscopy.
Benveniste H, Hedlund L, Johnson G. Mechanism of detection of acute cerebral ischemia in rats by diffusion-weighted magnetic resonance microscopy. Stroke 1992, 23: 746-754. PMID: 1374575, DOI: 10.1161/01.str.23.5.746.Peer-Reviewed Original ResearchConceptsAcute cerebral ischemiaCerebral ischemiaApparent diffusion coefficientOuabain exposureDiffusion-weighted magnetic resonance microscopyApparent diffusion coefficient reductionRight middle cerebral arteryIpsilateral common carotid arteryN-methyl-D-aspartate exposureFocal cerebral ischemiaMiddle cerebral arteryCommon carotid arteryApparent diffusion coefficient (ADC) valuesRat brain tissueTissue apparent diffusion coefficientCerebral arteryMicrodialysis membraneGlutamate exposureCorpus striatumOlfactory cortexCarotid arterySprague-DawleyBrain tissueIschemiaArtery
1989
Ischemic Damage in Hippocampal CA1 is Dependent on Glutamate Release and Intact Innervation from CA3
Benveniste H, Jørgensen M, Sandberg M, Christensen T, Hagberg H, Diemer N. Ischemic Damage in Hippocampal CA1 is Dependent on Glutamate Release and Intact Innervation from CA3. Cerebrovascular And Brain Metabolism Reviews 1989, 9: 629-639. PMID: 2570785, DOI: 10.1038/jcbfm.1989.90.Peer-Reviewed Original ResearchConceptsCA1 regionPyramidal cellsGlutamate releaseIntact innervationHippocampal tissueCA1 tissueInjection siteIschemia-induced releaseIschemia-induced damageTransient global ischemiaCA1 pyramidal cellsRelease of glutamateGlutamatergic afferentsIschemic damageHippocampal CA1CA1 pyramidsGlobal ischemiaCA3 regionPathogenetic significanceIschemiaNeurotoxic potentialCA3CA1GlutamateInnervation
1985
Cellular Origin of Ischemia‐Induced Glutamate Release from Brain Tissue In Vivo and In Vitro
Drejer J, Benveniste H, Diemer N, Schousboe A. Cellular Origin of Ischemia‐Induced Glutamate Release from Brain Tissue In Vivo and In Vitro. Journal Of Neurochemistry 1985, 45: 145-151. PMID: 2860206, DOI: 10.1111/j.1471-4159.1985.tb05486.x.Peer-Reviewed Original ResearchConceptsPotassium-induced releaseGlutamatergic neuronsAspartate uptakeConditions of hypoglycemiaCultured glutamatergic neuronsTransient cerebral ischemiaHigh potassiumExtracellular glutamate contentCerebral ischemiaGlutamate releaseTransmitter poolExtracellular glutamateMicrodialysis techniqueIschemiaBrain tissuePotassium stimulationPerfusion mediumHypoglycemiaGlutamate contentNeuronsInduced increasesCellular originVivo experimentsAstrocytesPrevious reports
1984
Elevation of the Extracellular Concentrations of Glutamate and Aspartate in Rat Hippocampus During Transient Cerebral Ischemia Monitored by Intracerebral Microdialysis
Benveniste H, Drejer J, Schousboe A, Diemer N. Elevation of the Extracellular Concentrations of Glutamate and Aspartate in Rat Hippocampus During Transient Cerebral Ischemia Monitored by Intracerebral Microdialysis. Journal Of Neurochemistry 1984, 43: 1369-1374. PMID: 6149259, DOI: 10.1111/j.1471-4159.1984.tb05396.x.Peer-Reviewed Original ResearchConceptsGamma-aminobutyric acidCerebral ischemiaIschemic periodTransient complete cerebral ischemiaTransient cerebral ischemiaComplete cerebral ischemiaExtracellular contentAmino acid glutamateDiameter dialysisIntracerebral microdialysisConcentrations of alanineExtracellular glutamateRat hippocampusCertain neuronsTaurine concentrationsIschemiaExtracellular concentrationHippocampusExtracellular fluidRinger's solutionGlutamateSame periodAspartateCausal factorsPeriod