1995
Nitric oxide synthase inhibition and extracellular glutamate concentration after cerebral ischemia/reperfusion.
Zhang J, Benveniste H, Klitzman B, Piantadosi C. Nitric oxide synthase inhibition and extracellular glutamate concentration after cerebral ischemia/reperfusion. Stroke 1995, 26: 298-304. PMID: 7530389, DOI: 10.1161/01.str.26.2.298.Peer-Reviewed Original ResearchConceptsIschemia/reperfusionBlood-brain barrierCerebral blood flowBrain ischemia/reperfusionExcitatory amino acidsExtracellular glutamate concentrationL-NAMEBlood flowGlutamate concentrationSynthase inhibitionL-arginineExcitatory amino acid toxicityL-NAME-treated ratsPostischemic cerebral blood flowNitric oxide synthase inhibitionCerebral ischemia/reperfusionBlood-brain barrier functionL-arginine methyl esterCerebral blood flow responseBlood-brain barrier permeabilityGlobal brain ischemia/reperfusionElevated glutamate concentrationsImmediate postischemic periodInterstitial glutamate concentrationL-NAME administration
1993
Inhibition of nitric oxide synthase increases extracellular cerebral glutamate concentration after global ischemia
Zhang J, Benveniste H, Piantadosi C. Inhibition of nitric oxide synthase increases extracellular cerebral glutamate concentration after global ischemia. Neuroscience Letters 1993, 157: 179-182. PMID: 7694195, DOI: 10.1016/0304-3940(93)90731-y.Peer-Reviewed Original ResearchConceptsGlutamate releaseGlutamate concentrationNitric oxide synthase inhibitionCerebral glutamate concentrationsOxide synthase inhibitionGlobal brain ischemiaInhibition of NOSNitric oxide synthaseExtracellular glutamate releaseCerebral microdialysisBrain ischemiaForebrain ischemiaControl ratsGlobal ischemiaNOS inhibitorOxide synthaseSynthase inhibitionCarotid arteryBrain flowDialysis probeIschemiaDialysate concentrationsControl valuesRatsReperfusion