1991
Quantitative proton magnetic resonance imaging in focal cerebral ischemia in rat brain.
Benveniste H, Cofer G, Piantadosi C, Davis J, Johnson G. Quantitative proton magnetic resonance imaging in focal cerebral ischemia in rat brain. Stroke 1991, 22: 259-268. PMID: 2003291, DOI: 10.1161/01.str.22.2.259.Peer-Reviewed Original ResearchConceptsSelective neuronal injuryFocal cerebral ischemiaArea of injuryCerebral ischemiaNeuronal injuryTotal slice areaIschemic penumbraWistar ratsRat brainCresyl violet-stained brain sectionsMR imagingUpper cortical layersMale Wistar ratsPermanent unilateral occlusionCommon carotid arteryHistological sectionsArea of infarctionMR imagesNormal brain tissueMagnetic resonance imagingCerebral cortexUnilateral occlusionHistological damageHalothane anesthesiaCarotid arteryThe excitotoxin hypothesis in relation to cerebral ischemia.
Benveniste H. The excitotoxin hypothesis in relation to cerebral ischemia. Cerebrovascular And Brain Metabolism Reviews 1991, 3: 213-45. PMID: 1931486.Peer-Reviewed Original ResearchConceptsExcitatory amino acidsSelective neuronal deathExcitotoxin hypothesisNeuronal deathExtracellular glutamate concentration increasesSelective vulnerable brain regionsBrain regionsN-methyl-D-aspartate receptorsGlutamate accumulationBrain cell injuryVulnerable brain regionsTransient global ischemiaHigh-performance liquid chromatographyDistinct brain regionsNeuronal injuryBrain extracellular spaceCerebral ischemiaTransient ischemiaAntagonist APVExcitatory neurotransmitterGlobal ischemiaExtracellular glutamateNMDA antagonistsCertain neuronsMicrodialysis technique
1989
Calcium 45 Accumulation in the Dentate Hilus: Possible Effect of NMDA Receptor Blockers
Benveniste H, Hüttemeier P, Johansen F, Diemer N. Calcium 45 Accumulation in the Dentate Hilus: Possible Effect of NMDA Receptor Blockers. 1989, 266-273. DOI: 10.1007/978-3-642-85863-5_34.Peer-Reviewed Original ResearchIntracellular calcium accumulationCalcium accumulationNeuronal cell injuryNMDA receptor blockerExcessive transmitter releaseIntracellular calcium concentrationFinal common pathwayReceptor blockersNeuronal injuryDentate hilusTransmitter releaseCell injuryCalcium channelsCalcium concentrationCommon pathwayInjuryCell deathPossible effectsHilusBlockers