1988
Calcium accumulation by glutamate receptor activation is involved in hippocampal cell damage after ischemia
Benveniste H, Jørgensen M, Diemer N, Hansen A. Calcium accumulation by glutamate receptor activation is involved in hippocampal cell damage after ischemia. Acta Neurologica Scandinavica 1988, 78: 529-536. PMID: 2906199, DOI: 10.1111/j.1600-0404.1988.tb03697.x.Peer-Reviewed Original ResearchConceptsGlutamate N-methyl-D-aspartate receptorN-methyl-D-aspartate receptorsCell damageNerve cell destructionComplete cerebral ischemiaBrain cell damageMin of ischemiaOnset of ischemiaHippocampal cell damageGlutamate receptor activationCA 1 regionRole of intracellularCerebral ischemiaIschemic periodBilateral destructionDenervated hippocampusAfferent inputSynaptic transmissionCalcium influxIschemiaCompetitive antagonistReceptor activationHistological studyCell destructionCalcium accumulation
1984
Elevation of the Extracellular Concentrations of Glutamate and Aspartate in Rat Hippocampus During Transient Cerebral Ischemia Monitored by Intracerebral Microdialysis
Benveniste H, Drejer J, Schousboe A, Diemer N. Elevation of the Extracellular Concentrations of Glutamate and Aspartate in Rat Hippocampus During Transient Cerebral Ischemia Monitored by Intracerebral Microdialysis. Journal Of Neurochemistry 1984, 43: 1369-1374. PMID: 6149259, DOI: 10.1111/j.1471-4159.1984.tb05396.x.Peer-Reviewed Original ResearchConceptsGamma-aminobutyric acidCerebral ischemiaIschemic periodTransient complete cerebral ischemiaTransient cerebral ischemiaComplete cerebral ischemiaExtracellular contentAmino acid glutamateDiameter dialysisIntracerebral microdialysisConcentrations of alanineExtracellular glutamateRat hippocampusCertain neuronsTaurine concentrationsIschemiaExtracellular concentrationHippocampusExtracellular fluidRinger's solutionGlutamateSame periodAspartateCausal factorsPeriod