1991
The excitotoxin hypothesis in relation to cerebral ischemia.
Benveniste H. The excitotoxin hypothesis in relation to cerebral ischemia. Cerebrovascular And Brain Metabolism Reviews 1991, 3: 213-45. PMID: 1931486.Peer-Reviewed Original ResearchConceptsExcitatory amino acidsSelective neuronal deathExcitotoxin hypothesisNeuronal deathExtracellular glutamate concentration increasesSelective vulnerable brain regionsBrain regionsN-methyl-D-aspartate receptorsGlutamate accumulationBrain cell injuryVulnerable brain regionsTransient global ischemiaHigh-performance liquid chromatographyDistinct brain regionsNeuronal injuryBrain extracellular spaceCerebral ischemiaTransient ischemiaAntagonist APVExcitatory neurotransmitterGlobal ischemiaExtracellular glutamateNMDA antagonistsCertain neuronsMicrodialysis technique
1984
Elevation of the Extracellular Concentrations of Glutamate and Aspartate in Rat Hippocampus During Transient Cerebral Ischemia Monitored by Intracerebral Microdialysis
Benveniste H, Drejer J, Schousboe A, Diemer N. Elevation of the Extracellular Concentrations of Glutamate and Aspartate in Rat Hippocampus During Transient Cerebral Ischemia Monitored by Intracerebral Microdialysis. Journal Of Neurochemistry 1984, 43: 1369-1374. PMID: 6149259, DOI: 10.1111/j.1471-4159.1984.tb05396.x.Peer-Reviewed Original ResearchConceptsGamma-aminobutyric acidCerebral ischemiaIschemic periodTransient complete cerebral ischemiaTransient cerebral ischemiaComplete cerebral ischemiaExtracellular contentAmino acid glutamateDiameter dialysisIntracerebral microdialysisConcentrations of alanineExtracellular glutamateRat hippocampusCertain neuronsTaurine concentrationsIschemiaExtracellular concentrationHippocampusExtracellular fluidRinger's solutionGlutamateSame periodAspartateCausal factorsPeriod