2023
Platelet response to influenza vaccination reflects effects of aging
Konstorum A, Mohanty S, Zhao Y, Melillo A, Vander Wyk B, Nelson A, Tsang S, Blevins T, Belshe R, Chawla D, Rondina M, Gill T, Montgomery R, Allore H, Kleinstein S, Shaw A. Platelet response to influenza vaccination reflects effects of aging. Aging Cell 2023, 22: e13749. PMID: 36656789, PMCID: PMC9924941, DOI: 10.1111/acel.13749.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAgingBlood PlateletsFrail ElderlyFrailtyHumansInfant, NewbornInfluenza, HumanVaccinationYoung AdultConceptsCommunity-dwelling older adultsPlatelet activationOlder adultsInfluenza vaccinationAge-associated chronic inflammationInfluence platelet functionRNA expressionPro-inflammatory diseasesAge-associated increasePlatelet activation pathwaysAge-associated differencesActivation pathwayPlatelet transcriptomeGeriatric conditionsChronic inflammationImmune responsePlatelet functionPlatelet responseSNF residentsVaccinationActivation responseYoung individualsProtein levelsAdultsYounger participants
2010
Change in Disability After Hospitalization or Restricted Activity in Older Persons
Gill TM, Allore HG, Gahbauer EA, Murphy TE. Change in Disability After Hospitalization or Restricted Activity in Older Persons. JAMA 2010, 304: 1919-1928. PMID: 21045098, PMCID: PMC3124926, DOI: 10.1001/jama.2010.1568.Peer-Reviewed Original ResearchConceptsHazard ratioPhysical frailtySevere disabilityOlder personsMild disabilityMultivariable hazard ratiosProspective cohort studyCommunity-living personsFall-related injuriesGreater New HavenState of disabilityLikelihood of recoveryCohort studyAbsolute riskFrail individualsHospitalizationDaily livingNonfrail individualsRestricted activityInjuryTelephone interviewsFrailtyIllnessMonthsDisability
2002
A Program to Prevent Functional Decline in Physically Frail, Elderly Persons Who Live at Home
Gill TM, Baker DI, Gottschalk M, Peduzzi PN, Allore H, Byers A. A Program to Prevent Functional Decline in Physically Frail, Elderly Persons Who Live at Home. New England Journal Of Medicine 2002, 347: 1068-1074. PMID: 12362007, DOI: 10.1056/nejmoa020423.Peer-Reviewed Original ResearchConceptsFunctional declineControl groupElderly personsDisability scoresIntervention groupLower-body dressingMore severe disabilityPrevent Functional DeclineHome-based intervention programFrequency of admissionHome-based programSuch functional declinePersons 75 yearsBase lineSevere frailtyPrimary outcomeSubstantial morbidityModerate frailtyMuscle strengthDisability ScalePhysical abilityPhysical therapyDaily livingNursing homesSix months